DOI: https://doi.org/10.22141/2224-0721.3.75.2016.76634

Prevalence of Growth Hormone Deficiency in Adults with Pituitary Adenomas

М.S. Sаidnazikrhanova, Yu.М. Urmanova

Abstract


In this article, the authors analyzed the data of patients with pituitary tumors, of which 35 (87.5 %) suffered from growth hormone deficiency (GHD) in adults with neuroendocrine complications. Specific to GHD is a group of symptoms of mental and emotional disorders, which is determined based on a questionnaire. According to the treatment mode, there were 3 groups of patients on conservative treatment (n = 15), after surgery (n = 20), after radiotherapy and conservative or surgical treatment (n = 5). The control group consisted of 20 healthy age-matched individuals. Study of the quality of life in patients with GHD on the basis of a questionnaire (QoL) revealed the highest average score in these patients compared to the healthy group (p < 0.01), indicating a significant reduction of psychoemotional status in patients with GHD. It was found that GHD in adult patients with different formations of the sellar region was identified in 87.5 % of cases (35 patients out of 40 surveyed). The peculiarity of the clinical manifestations of GHD in adults is a significant deterioration of the mental and emotional state of patients on the background of neuroendocrine disorders.


Keywords


growth hormone deficiency in adults; hypopituitarism; pituitary adenomas; incidence.

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