Prevalence of Оsteoporosis and Low Bone Mineral Density in Ukrainian Women with Obesity and Metabolic Syndrome

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V.V. Povoroznyuk
L.P. Martyniuk


Objective: to determine the incidence of osteoporosis and low bone mineral density (BMD) in Ukrainian women with obesity and metabolic syndrome. Materials and methods. The study involved 1,605 persons, whose mean age was 62.31 ± 9.52 years, the average body mass — 76.48 ± 14.65 kg. All women were in postmenopausal period. Patients were divided into three groups. First group (800 people) included women without obesity, second one (572 persons) — with obesity. Third group (233 people) consisted of patients with metabolic syndrome. BMD of lumbar spine and femoral neck was measured by dual-energy X-ray absortiometer (Prodigy, 2005). Conclusion about normal BMD, osteoporosis and low BMD was made according to the ISCD (2007) criteria for official position (updated in 2015). Results. The incidence of osteoporosis and low BMD in women from the second and third groups were compared with those in the first group. We have found no significant differences in performance of BMD between patients of second and third groups unlike the first group. Conclusions. In patients with obesity and metabolic syndrome, the prevalence of osteoporosis and low BMD is significantly lower as compared with the group of women without obesity, and metabolic syndrome and obesity have equally positive effect on bone mineral density.

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How to Cite
Povoroznyuk, V., and L. Martyniuk. “Prevalence of Оsteoporosis and Low Bone Mineral Density in Ukrainian Women With Obesity and Metabolic Syndrome”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), no. 3.75, June 2016, pp. 13-18, doi:10.22141/2224-0721.3.75.2016.76625.
Original Researches


Zagajko AL, Voronina LM, Strel`chenko KV. Metabolic syndrome: mechanism of development and prospects of antioxidant therapy Monografiya. – Н.: Vy`d-vo NFaU: Zoloti storinky`, 2007 – 216 с. Ukrainian.

Makolkin VI. Metabolic syndrome. – M.: OOO ”Meditsinskoe informatsionnoe agentstvo”, 2010. – 144 с. Russian.

Mamedov MN. How to prevent the risk of coronary heart disease and diabetes? // Mizhnarodny`j endokry`nologichny`j zhurnal. 2007;5(11):47-60. Russian.

Osteoporosis: clinical picture, diagnosis, prevention and treatment. Korzh NA, Povoroznyuk VV, Dedux NV, Zupanecz ІA. – Kharkov: Zolotyie stranitsyi, 2002. – 486 s. Russian.

Povoroznyuk VV. Modern principles of diagnosis, prevention and treatment of diseases of the musculoskeletal system in the elderly. Zbirny`k naukovy`x pracz`. Vy`pusk 1. Pid red. profesora Povoroznyuk V.V.-K.: VPCz «Ekspres», 2008 – 276 с. Ukrainian.

Povoroznyuk VV. The disease of bone-muscle system in people of all ages (selected lectures, reviews, articles ): Т.4. – К., 2014. – 672 s. Ukrainian.

Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications: Part 1: diagnosis and classification of diabetes mellitus provisionаl report of a WHO consultation. Diabet Med. 1998 Jul;15(7):539-53. PMID:9686693 [PubMed - indexed for MEDLINE].

Fatima SS, Farooq S, Tauni MA, Irfan O, Alam F. Effect of raised body fat on vitamin D, leptin and bone mass. J Pak Med Assoc. 2015 Dec;65(12):1315-9. PMID:26627514 [PubMed - in process] Free full text.

Freitas PM, Garcia Rosa ML, Gomes AM, Wahrlich V, Di Luca DG, da Cruz Filho RA, da Silva Correia DM, Faria CA, Yokoo EM. Central and peripheral fat body mass have a protective effect on osteopenia or osteoporosis in adults and elderly? Osteoporos Int. 2016 Apr;27(4):1659-63. doi: 10.1007/s00198-015-3414-5. Epub 2015 Dec 9.

Gonelli S, Caffarelli C, Nuti R. Obesity and fracture risk. Clin. Cases Miner. Bone Metab. 2014;11(1): 9-14.

International Diabetes Federation. Worldwide definition of the metabolic syndrome. Available at: http: // Metasyndrome definition. pdf. Accessd, August 24,2005.

Kim BJ, Ahn SH, Bae SJ, Kim EH, Kim TH, Lee SH, Kim HK, Choe JW, Kim SY, Koh JM, Kim GS Association between metabolic syndrome and bone loss at various skeletal sites in postmenopausal women: a 3-year retrospective longitudinal study. Osteoporos Int. 2013;24(8):2243-52. doi: 10.1007/s00198-013-2292-y. Epub 2013 Feb 7.

Lu LJ, Nayeem F, Anderson KE, Grady JJ, Nagamani M. Lean body mass, not estrogen or progesterone, predicts peak bone mineral density in premenopausal women. J Nutr. 2009;139(2):250-6.

Maghraoui A, Sadni S, El Maataoui A, Majjad A, Rezqi A, Ouzzif Z, Mounach A. Influence of obesity on vertebral fracture prevalence and vitamin D status in postmenopausal women. Nutr Metab (Lond). 2015;12:44. doi: 10.1186/s12986-015-0041-2. eCollection 2015. PMID:26583038 [PubMed]

Maïmoun L, Mura T, Leprieur E, Avignon A, Mariano-Goulart D, Sultan A. Impact of obesity on bone mass throughout adult life: Influence of gender and severity of obesity. Bone. 2015 Dec 1. pii: S8756-3282(15)00421-4. doi: 10.1016/ j.bone.2015.11.020.

Official Positions of the International Society for Clinical Densiometry, Copyright ISCD, October 2007,

Poiana C, Carsote M, Radoi V, Mihai A, Capatina C. Prevalent osteoporotic fractures in 622 obese and non- obese menopausal women. J Med Life. 2015; 8(4): 462-466. PMCID: PMC4656953

Shen J, Leslie WD, Nielson CM, Majumdar SR, Morin SN, Orwoll ES. Associations of Body Mass Index With Incident Fractures and Hip Structural Parameters in a Large Canadian Cohort. J Clin Endocrinol Metab. 2016;101(2):476-84. doi: 10.1210/jc.2015-3123.

Vicente Gilsanz, James Chalfant, Ashley O. Mo, David C. Lee, Frederick J. Dorey, and Steven D. Mittelman Reciprocal Relations of Subcutaneous and Visceral Fat to Bone Structure and Strength. J Clin Endocrinol Metab. 2009; 94(9): 3387-3393. doi: 10.1210/jc.2008-2422 PMCID: PMC2741723

World Health Organization. Obesity: preventing and managing the global epidemic. Report of a WHO consultation on obesity. World Health Organization: Geneva, 2000, 9 p.

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