Features of Immune and Metabolic Changes in patients with Combined Endocrine Pathology and Vitamin D3 Deficiency

Main Article Content

Yu.I. Komisarenko
A.I. Kurchenko
O.V. Antonenko


Aim. To study the cytokines background concentration in patients with combined endocrine pathology — diabetes mellitus (DM) type 1 or 2 and autoimmune thyroiditis secondary to vitamin D3 deficiency.
Methods. The examined patients with DM type 1 and type 2 combined with autoimmune thyroiditis had reduced levels of D3 vitamin. They were divided into two groups of 28 and 30 patients respectively. All patients with autoimmune thyroiditis had hypothyroidism. The levels of Th1-cytokine profile (IFN-γ, TNF-α, IL-2, IL-6, IL-12), Th2-profile (IL-4, IL-5) and IL-10 and IL-17 were determined. The amount of vitamin D3 was assessed by the level of 25(OH)D.
Results. The patients with combined endocrine disorders — DM and autoimmune thyroiditis (with hypothyroidism) secondary to vitamin D3 deficiency had a significant increase in the background concentration of Th1-cytokine profile (IFN-γ, TNF-α, IL-2, IL-6, IL-12) and a reduced cytokine concentrations of Th2-cytokine profile (IL-4, IL-5) as well as IL-10 and IL-17.
Conclusions. The presence of two endocrine diseases and florid vitamin D3 deficiency leads to an imbalance in the immune status of patients, supports an autoimmune inflammatory process and contributes to the progression or advanced development of complications. Further research may confirm the need for the use of vitamin D3 for the prevention and treatment of multiple endocrinopathy to correct metabolic and immunological changes.

Article Details

How to Cite
Komisarenko, Y., A. Kurchenko, and O. Antonenko. “Features of Immune and Metabolic Changes in Patients With Combined Endocrine Pathology and Vitamin D3 Deficiency”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), no. 3.59, June 2014, pp. 22-26, doi:10.22141/2224-0721.3.59.2014.76599.
Original Researches


Боднар П.М., Комісаренко Ю.І., Конах В.М., Матюшенко В.В. Автоімунний полігландулярний синдром // Лікування та діагностика. — 2001. — № 2. — С. 31-36.

Боднар П.М., Комісаренко Ю.І. Автоімунні поліендокринопатії // Мистецтво лікування. — 2004. — № 3. — С. 62-64.

Burek C.L. Autoimmune thyroiditis research at Johns Hopkins University // Immunol. Res. — 2010. — Vol. 47. — P. 207-215.

Harrison’s Endocrinology / J. Larry Jameson. — Mc Grew-Hill, USA, 2006. — 563 p.

James W.P.T. 22nd Marabou Symposium: The changing faces of vitamin D / W.P.T. James // Nutr. Rev. — 2008. — Vol. 66. — P. 286-290.

Panda D.K. Targeted ablation of the 25-hydroxyvitamin D1 alpha-hydroxylase enzyme: evidence for skeletal reproductive and immune dysfunction / D.K. Panda, D. Miao, M.L. Tremblay [et al.] // Proc. Natl. Acad. Sci. USA. — 2001. — Vol. 98, № 13. — P. 7498-7503.

Rojas-Rivera J. The expanding spectrum of biological actions of vitamin D / J. Rojas-Rivera, C. De La Piedra, A. Ramos [et al.] // Nephrol. Dial. Transplant. — 2010. — Vol. 25(9). — P. 2850-2865.

Yamamoto H. The caudal-related homeo-domain protein Cdx-2 regulates vitamin D receptor gene expression in the small intestine / H. Yamamoto [et al.] // J. Bone Miner. Res. — 1999. — Vol. 14, № 2. — P. 240-247.

Maiyar A.C. Vitamin D / A.C. Maiyar, A.W. Norman // Enciclopedia of human biology. — London: Acad. Press, 1991. — Vol. 7. — P. 859-871.