Significance of Using Questionnaire «Quality of Life Assessment in Adults with Growth Hormone Deficiency» in Patients with Non-functioning Pituitary Adenomas and Various Tumors of Chiasmosellar Area in Pre and Postoperative Period

Yu.M. Urmanova, M.Yu. Shakirova, D.A. Aliyeva


The authors surveyed 136 adult patients with growth hormone deficiency (GHD) of various origins (pituitary tumors and IHD — a comparison group). Study based on GHD questionnaire QoL-AGHDA quality of life of 136 patients revealed that in all groups the mean score was higher than normal in comparison with normative data (normal < 11 points), at that the most reliable it was observed in patients from the first, third, fourth groups and second subgroup of the fifth group of patients. Significant correlation between low basal values of GH, IGF-1 in blood plasma and average values of the GHD questionnaire QoL-AGHDA was found in 1st, 2nd, 3rd, 4th groups and the second subgroup of 5th group of patients, which confirms the high efficiency of using GHD questionnaire QoL-AGHDA in patients with GHD of various origins. In 36 patients 3 months after the TGE there was significant increase of mean scores by GHD questionnaire against decrease of average values of GH and IGF-1. This shows that in the early postoperative period in patients increases the severity of hypopituitarism, and raises the question of the administration of hormone replacement therapy.


adult growth hormone deficiency; pituitary adenoma; transnasal selective hypophysectomy


Дедов И.И., Мельниченко Г.А. Эндокринология. Национальное руководство. — М., 2009. — 597 с.

Марова Е.И. Нейроэндокринология. Клинические очерки. — М., 1999. — С. 380-401.

Agrawal D., Mahapatra A.K. Visual outcome of blind eyes in pituitary apoplexy after transsphenoidal surgery: a series of 14 eyes // Surg. Neurol. — 2005. — Vol. 63. — P. 42-46.

Anderson D., Faber P., Marcovitz S. Pituitary tumors and the ophthalmologist // Ophthalmology. — 1983. — Vol. 90. — P. 1265-1270.

Assessment of Cardiovascular Risk in Patients with Growth Hormone Deficiency Following Transsphenoidal Surgery for Nonsecreting Pituitary Adenomas.Verified by: Columbia University, April 2011. First Received: March 25, 2008 / Last Updated: April 22, 2011 / Phase: N/A / Start Date: March 2008 Link to the current record. Study ID Number: AAAB9681. Identifier: NCT00646308. Health Authority: United States: Institutional Review Board.

Black P.M, Zervas N.T., Candia G. Management of large pituitary adenomas by transsphenoidal surgery // Surgical Neurology. — 1988. — Vol. 29. — P. 443-447.

Bertella L., Mori I., Grugni G. et al. Quality of life and psychological well-being in GH-treated, adult PWS patients: a longitudinal study // J. Intellect. Disabil. Res. — 2007. — Vol. 51. — P. 302-311.

Baldelli R., Bianchi A., Diacono F., Passeri M. еt al. Characteristics of adult patients with growth hormone deficiency who underwent neurosurgery for functioning and non-functioning pituitary adenomas and craniopharyngiomas // J. Endocrinol. Invest. — 2005. — Vol. 28 (2). — P. 157-161.

Cohen A.R., Cooper P.R., Kupersmith M.J. Visual recovery after transsphenoidal removal of pituitary adenomas // Neurosurgery. — 1985. — 17. — 446-452.

Comtois R., Beauregard H., Somma M. The clinical and endocrine outcome to trans-sphenoidal microsurgery of nonsecreting pituitary adenomas // Cancer. — 1991. — Vol. 68. — P. 860-866.

Clayton P.E., Shalet S.M. Dose dependency of time of onset of radiation-induced growth hormone deficiency // J. Pediatr. — 1991. — Vol. 18. — P. 2.

Chrousos G.P., Poplack D., Brown T. et al. Effects of cranial radiation on hypothalamic-adenohypophyseal function: Abnormal growth hormone secretory dynamics // J. Clin. Endocrinol. Metab. — 1982. — Vol. 54. — P. 1135-1139.

Growth Hormone Research Society (GRS): Consensus guidelines for the diagnosis and treatment of adults with GH deficiency: Summary statement of the GRS workshop on adult GHD // J. Clin. Endocrinol. Metab. — 1998. — Vol. 34. — P. 379-381.

Jorgensen J.O. Christiansen L. GHD in adults / Ed. by A.B. Grossman // Denmark, Frontiers of Hormone research. — 2005. — Vol. 33. — Р. 22.

Fitzek M.M., Linggood R.M., Adams J. Combined proton and photon irradiation for craniopharyngioma: long-term results of the early cohort of patients treated at Harvard Cyclotron Laboratory and Massachusetts General Hospital // Int. J. Radiat. Oncol. Biol. Phys. — 2006. — Vol. 64 (5). — P. 1348-1354.

Kendall-Taylor P., Jönsson P.J., Abs R. The clinical, metabolic and endocrine features and the quality of life in adults with childhood-onset craniopharyngioma compared with adult-onset craniopharyngioma // Eur. J. Endocrinol. — 2005. — Vol. 152 (4). — P. 557-567.

Kirk J.A., Raghupathy P., Stevens M.M. et al. Growth failure and growth-hormone deficiency after treatment for lymphoblastic leukaemia // Lancet. — 1987. — P. 190-193.

Littley M.D., Shalet S.M., Beardwell C.G. et al. Hypopituitarism following external radiotherapy for pituitary tumors in adults // Q. J. Med. — 1988. — Vol. 262. — P. 145-160.

Long Term Post Operative Follow-Up of Cushing Syndrome. Verified by: National Institutes of Health Clinical Center (CC), September 2004. First Received: January 26, 2002 / Last Updated: March 3, 2008 / Phase: N/A / Start Date: July 1993. Link to the current record. Study ID Number: 930169. Clinical. Identifier: NCT00029952. Health Authority: United States: Federal Government.

Mortini P., Losa M., Barzaghi R. Results of transsphenoidal surgery in a large series of patients with pituitary adenoma // Neurosurgery. — 2005. — Vol. 56. — P. 1222-1233.

Pecori Giraldi F., Andrioli M., De Marinis L. et al. Significant GH deficiency after long-term cure by surgery in adult patients with Cushing's disease // Eur. J. Endocrinol. — 2007. — Vol. 156 (2). — P. 233-239.

Pollock B.E., Nippoldt T.B., Stafford S.L. et al. Results of stereotactic radiosurgery in patients with hormone-producing pituitary adenomas: factors associated with endocrine normalization // J. Neurosurg. — 2002. — Vol. 97 (3). — P. 525-530.

Sara M., Claudio F., Marco L. et al. Time course of hypothalamic-pituitary deficiency in adults receiving cranial radiotherapy for primary extrasellar brain tumors // Radiother. Oncol. — 2011. — Vol. 99 (1). — P. 23-28.

Sheehan J.P., Pouratian N., Steiner L. Gamma Knife surgery for pituitary adenomas: factors related to radiological and endocrine outcomes // J. Neurosurg. — 2011. — Vol. 114 (2). — P. 303-309.

Wallymahmed M.E., Foy P., MacFarlane I.A. The quality of life of adults with growth hormone deficiency: Comparison with diabetic patients and control subjects // Clin. Endocrinol. (Oxf). — 1999. — 51. — 333-338.

Copyright (c) 2020 Yu.M. Urmanova, M.Yu. Shakirova, D.A. Aliyeva

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© "Publishing House "Zaslavsky", 1997-2020


   Seo анализ сайта