Intracardia сHemodynamics in Hypertensive Patients with Diabetes Mellitus Type 2

I.M. Fushtey, E.Yu. Gura


The aim of the work was to determine the characteristics of intracardiac hemodynamics in patients with essential hypertension (EH) stage II in combination with type 2 diabetes mellitus (DM). The research involved 120 patients aged 53.7 ± 5.6 years and 30 apparently healthy individuals of the same age. The main group consisted of 60 patients with essential hypertension stage II with the second (30 patients) and the third (30 patients) degree of arterial hypertension (AH). The comparison group included 30 patients with type 2 diabetes mellitus and 30 patients with EH stage II.
The intracardiac hemodynamics was studied with the help of the digital Doppler ultrasound diagnostic scanner Ultima Pro-30 with the examination of systolic and diastolic function of the left ventricle (LV) according to generally accepted criteria.
It was found that comparison group (patients with type 2 DM), as compared with group of healthy individuals, showed a significant changes of indicators which determine the left ventricular systolic function — increase of the linear and volumetric parameters of LV against decrease of its contractile function. In the comparison group (patients with EH stage II) the specified parameters changed in the same direction and were more reliable in comparison with the patients with type 2 DM. In the main group the mentioned changes of indicators characterizing the left ventricular systolic function were more expressed and significantly differed from the control group of the patients with EH. The most significant were also parameters that characterized the left ventricular diastolic function in the patients of the main group (EH associated with type 2 DM) and they mostly depended on the level of LV hypertrophy. It should also be noted that changes in the indicators of systolic and diastolic LV function directly depended on blood pressure level and were significantly and maximally changed in the third degree of AH hypertension.


intracardiac hemodynamics; left ventricular systolic function; left ventricle diastolic function; type 2 diabetes mellitus


Маньковский Б.Н. Частота выявления новых случаев сахарного диабета 2-го типа и эффективность сахароснижающей терапии у впервые выявленных пациентов: результаты исследования DIABETTER // Ліки України. — 2011. — № 10(156). — С. 14-19.

Сіренко Ю.М. Артеріальні гіпертензії. — К.: Моріон, 2002. — 203 с.

Адаптована клінічна настанова, заснована на доказах «Цукровий діабет 2 типу». Наказ МОЗ України від 21.12.2012 № 1118 «Про затвердження та впровадження медико-технологічних документів зі стандартизації медичної допомоги при цукровому діабеті 2 типу».

The Task Force for the management of arterial hypertension of the European Society of Hypertension and of the European Society of Cardiology. 2007 Guidelines for the management of arterial hypertension // J. Hypertens. — 2007. — Vol. 25. — P. 1105-1187.

Nathan D.M., Buse J.B., Davidson M.B. et al. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes // Diabetes Care. — 2009. — Vol. 32(1). — P. 193-203.

Pater C. Current trends in the cardiovascular clinical trial arena (I) // Curr. Control. Trials Cardiovasc. Med. — 2004. — Vol. 5. — P. 4-8.

Okin P.M., Devereux R.B., Liu J.E. et al. Regression of electrocardiographic left ventricular hypertrophy predicts regression of echocardiographic left ventricular mass: the LIFE Study // J. Hum. Hypertens. — 2004. — Vol. 18. — P. 403-409.

Takiuchi S., Kamide K., Miwа Y. et al. Diagnostic value of carotid intima-media thickness and plaque score for predicting target organ damage in patients with essential hypertension // J. Hum. Hypertens. — 2004. — Vol. 18. — P. 17-23.

Verdecchia P., Angeli F., Borgioni C. et al. Changes in cardiovascular risk by reduction of left ventricular mass in hypertension: a meta-analysis // Am. J. Hypertens. — 2003. — Vol. 16. — P. 895-899.



  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© "Publishing House "Zaslavsky", 1997-2017


 Яндекс.МетрикаSeo анализ сайта Рейтинг