A Case of Primary Hyperparathyroidism Combined with Cushing Syndrome due to Ectopic ACTH Secretion

N.T. Rikhsiieva, Yu.M. Urmanova, F.S. Khodzhaieva


A rare case of primary hyperparathyroidism (PHPT) combined with Cushing syndrome due to ectopic ACTH secretion in 37-year-old women is described. The patient gradually underwent surgeries after compensation of general condition: bilateral parathyroidectomy, in 4 months — removal of carcinoid tumor of the lung. In case of Cushing syndrome or PHPT, the authors recommended to carry out careful examination of patients to exclude MEN-1 and MEN-2 syndromes. In addition, it is necessary to exclude the presence of familial forms of the disease, i.e., it is necessary to carry out a survey of first-degree relatives.


primary hyperparathyroidism; Cushing syndrome


Голохвастов Н.Н. Клинические формы первичного гиперпаратиреоза // Актуальные проблемы современной эндокринологии: Материалы IV Всероссийского конгресса эндокринологов. — СПб., 2001. — С. 293.

Котова И.В. Сочетание первичного гиперпаратиреоза и патологии щитовидной железы // Вестник хирургии. — 2003. — № 5. — С. 67-68.

Исмаилов С.И., Урманова Ю.М., Халимова З.Ю. Частота и этиология различных форм гиперкортицизма в детском, подростковом и юношеском возрасте по данным ретроспективного анализа // Международный эндокринологический журнал. — 2012. — № 4. — С. 12-18.

Gopinath P., Sadler G.P., Mihai R. Langenbecks symptomatic improvement in the majority of patients undergoing parathyroidectomy for primary hyperparathyroidism // Arch. Surg. — 2010. — Vol. 395(7). — P. 941-946.

Kollars J., Zarroug A.E., van Heerden J. Primary hyperparathyroidism in pediatric patients // Pediatrics. — 2005. — Vol. 115(4). — P. 974-980.

Iacobone M., Lumachi F., Favia G. Up-to-date on parathyroid carcinoma: analysis of an experience of 19 cases // J. Surg. Oncol. — 2004. — Vol. 88(4). — P. 223-228.

Leong K.J., Sam R.C., Garnham A.W. Health-related quality of life improvement following surgical treatment of primary hyperparathyroidism in a United Kingdom population // Surgeon. — 2010. — Vol. 8(1). — P. 5-8.

Lindholm J. Incidence and late prognosis of Cushing’s syndrome: A population-based study. // J. Clin. Endocrinol. Metab. — 2001. — Vol. 86. — P. 117-123.

Loh K.C., Duh Q.Y., Shoback D. Clinical profile of primary hyperparathyroidism in adolescents and young adults // Clin. Endocrinol. (Oxf). — 1998. — Vol. 48(4). — P. 435-443.

Pradeep P.V., Mishra A., Agarwal G. Long-term outcome after parathyroidectomy in patients with advanced primary hyperparathyroidism and associated vitamin D deficiency // World J. Surg. — 2008. — Vol. 32(5). — P. 829-835.

Söreide J.A., van Heerden J.A., Grant C.S. Survival after surgical treatment for primary hyperparathyroidism // Surgery. — 1997. — Vol. 122(6). — P. 1117-1123.

Wagner P.K., Rothmund M. Long-term results after implantation of autologous cryopreserved parathyroid tissue // Dtsch. Med. Wochenschr. — 1990. — Vol. 115(49). — P. 1863-1867.

Kraimps J.L., Deleplanque G., Carretier M. Long-term results of surgery of primary hyperparathyroidism // J. Chir. (Paris). — 1989. — Vol. 126(10). — P. 517-520.

Saubier E.C., Faysse E., Gouillat C. Surgical treatment of primary hyperparathyroidism. Evaluation of 263 cases // J. Chir. (Paris). — 1983. — Vol. 120(12). — P. 693-699.

DOI: https://doi.org/10.22141/2224-0721.1.65.2015.75927


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© "Publishing House "Zaslavsky", 1997-2018


 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru