Influence of Subclinical Hypothyroidism on Women Reproductive Function and Efficiency of its Correction

N.V. Pasiechko, S.V. Hnat, І.І. Svystun, L.V. Naumova

Abstract


The article presents the results of the study involved 21 women with infertility and thyroid dysfunction (thyroid stimulating hormone (TSH) level exceeded 2.5 µIU/mL). Women received hormone replacement therapy with L-thyroxine in doses recommended by European Thyroid Association. During the study, 9 (42.85 %) women became pregnant. The findings lead us to conclusions: 1) determining the functional state of the thyroid is essential when planning pregnancy, at infertility, physiological and pathological pregnancy; 2) replacement therapy with L-thyroxine is necessary for women with infertility and those planning pregnancy with TSH levels > 2.5 µIU/mL, and in exceeded maximum TSH values recommended by European Thyroid Association in different periods of pregnancy.


Keywords


subclinical hypothyroidism; infertility; pregnancy; thyroid gland; levothyroxine

References


Балаболкин М.И., Клебанова Е.М., Креминская В.М. Фундаментальная и клиническая тироидология (руководство). — М.: Медицина, 2007. — 816 с.

Данилова Л.И. Болезни щитовидной железы и ассоциированные с ними заболевания. — Минск; Нагасаки, 2005. — 470 с.

Методические рекомендации Европейской тиреоидной ассоциации по ведению пациентов с субклиническим гипотиреозом в период беременности и в детском возрасте // Eur. Thyroid J. — 2014. — Vol. 3. — P. 76-94.

Фадеев В.В. Заместительная терапия гипотиреоза: нерешенные проблемы или предрассудки прошлого // Клиническая и экспериментальная тиреоидология. — 2010. — № 2. — С. 3-10.

Abalovich M., Nobuyuki A., Barbour L.A. et al. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society Clinical Practice Guideline // J. Clin. Endocrinol. Metabol. — 2007. — Vol.92. — P. 1-47.

Canaris G.I., Manovitz N.R., Mayor G.M., Ridgway E.C. The Colorado thyroid disease prevalence study // Arch. Intern. Med. — 2000. — Vol. 160. — P. 526-534.

Cooper D.S. Clinical practice: subclinical hypothyroidism // N. Engl. J. Med. — 2001. — Vol. 354. — P. 260-265.

Glinoer, D. Gestational hypothyroxinemia and the beneficial effects of early dietary iodine fortification thyroid / D. Glinoer, J. Royet // Thyroid. — 2009. — Vol. 19, № 5. — P. 431-434.

Gudmundsdottir A., Schlechte J.A. Central hypothyroidism // Endocrinologist. — 2002. — Vol. 12. — P. 218-223.

Hueston W.J. Treatment of hypothyroidism // Am. Fam. Physician. — 2001. — Vol. 64. — P. 1717-1724.

Lind P., Langsteger W., Molnar M. et al. Epidemiology of thyroid diseases in iodine sufficiency // Thyroid. — 1998. — Vol. 8. — P. 1179-1183.

Martino E., Bartalena L., Pinchera A. Central hypothyroidism // Werner and Ingbars’ the Thyroid / Ed. by L.E. Braverman. — Philadelphia, 2000. — P. 762-771.

Nussey S.S., Whitehead S.A. Endocrinology. An integrated approach. — BIOS Scientific Publishers Limited, 2001. — 358 p.

Poppe K. Female infertility and the thyroid [Text] / K. Poppe, B. Volkeniers // Clin. Endocrinol. Metab. — 2004. — Vol. 18, № 2. — P. 153-165.

Soldin O.P. Therapeutic drug monitoring during pregnancy and lactation: thyroid function assessment in pregnancy-challenges and solutions // Therapeutic Drug Monitoring. — 2010. — Vol. 32, № 3. — P. 265-268.




DOI: https://doi.org/10.22141/2224-0721.1.65.2015.75910

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© "Publishing House "Zaslavsky", 1997-2017

 

 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru