Features of Thyroid Functional State in Patients with Type 2 Diabetes Mellitus and Obesity
We have observed 55 patients with diabetes mellitus (DM) type 2 and obesity without signs of thyroid function abnormality, as well as 60 patients with DM type 2 and obesity combined with overt or subclinical hypothyroidism. The objective of the study was to evaluate the indicators of thyroid functional state in patients with type 2 DM and obesity. It is shown that patients with type 2 DM combined with hypothyroidism have a higher incidence of hypertriglyceridemia. In these patients, there are higher rates of body weight, low-density lipoproteins (LDL) than in patients with type 2 DM without thyroid dysfunction. Patients with type 2 DM in combination with symptomatic hypothyroidism are characterized by higher levels of body weight, total cholesterol, LDL, triglycerides and lower high-density lipoproteins indicators than those with DM type 2 associated with subclinical thyroid dysfunction. With an increasing number of metabolic syndrome components, deterioration in carbohydrate and lipid metabolism is being detected in examined patients that can lead to increased cardiovascular risks.
Full Text:PDF (Українська)
Grundmann N., Mielck A., Siegel M., Maier W. Area deprivation and the prevalence of type 2 diabetes and obesity: analysis at the municipality level in Germany // BMC Public Health. — 2014. — 14. — 1264. — doi: 10.1186/1471-2458-14-1264.
Vanderpump M. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham survey / M. Vanderpump, W. Tunbridge, J. French // Clinical Endocrino-logy. — 1995. — Vol. 43. — P. 55-58.
Canaris G.J., Manowitz N.R., Mayor G., Ridgway E.C. The Colorado Thyroid Disease Prevalence Study // Archives of Internal Medicine. — 2000. — Vol. 160, № 4. — P. 526-534.
Hollowell J.G., Staehling N.W., Flanders W.D. et al. Serum TSH, T4 and thyroid antibodies in the United States population (1988 to 1994): national health and nutrition examination survey // J. Clin. Endocrinol. Metab. — 2002. — Vol. 87. — P. 489-499.
Maratou E., Hadjidakis D.J., Kollias A. et al. Studies of insulin resistance in patients with clinical and subclinical hypothyroidism // European Journal of Endocrinology. — 2009. — Vol. 160, № 5. — P. 785-790.
Chen H.S., Wu T.E.J., Jap T.S. et al. Subclinical hypothyroidism is a risk factor for nephropathy and cardiovascular diseases in Type 2 diabetic patients // Diabetic Medicine. — 2007. — Vol. 24, № 12. — P. 1336-1344.
Щитовидная железа и менопаузальный метаболический синдром / Дерябина Е.Г., Башмакова Н.В. // Вестник Уральской медицинской академической науки. — 2009. — № 4. — С. 18-20.
Maratou E., Hadjidakis D.J., Peppa M. et al. Studies of insulin resistance in patients with clinical and subclinical hyperthyroidism // Eur. J. Endocrinol. — 2010. — Vol. 163. — P. 625-630.
Rezzonico J., Rezzonico M., Pusiol E. et al. Introducing the thyroid gland as another victim of the insulin resistance syndrome // Thyroid. — 2008. — Vol. 18. — P. 461-464.
Copyright (c) 2020 Т.Yu. Yuzvenko
This work is licensed under a Creative Commons Attribution 4.0 International License.
© "Publishing House "Zaslavsky", 1997-2020