Diagnostic Markers and the Method of Predicting Chronic Pancreatitis Development in Patients with Type 2 Diabetes Mellitus

L.V. Zhuravlyova, Yu.O. Shekhovtsova, A.V. Arseniev

Abstract


The purpose of the present study was to determine the diagnostic markers and the method of predicting of chronic pancreatitis in type 2 diabetes mellitus patients. Materials and methods. A total of 94 patients (33 males and 61 females, mean aged 58.94 ± 1.02) with type 2 diabetes mellitus were examined. The patients were divided into 2 groups: 1st group (n = 32) includes patients with isolated type 2 diabetes mellitus, 2nd group (n = 62) consisted of combined course of type 2 diabetes mellitus and chronic pancreatitis. Results. It was found significantly increased levels of apelin and tumor necrosis factor alpha, and worsening of indicators of carbohydrate, lipid metabolism and functional state of the pancreas in combined course of chronic pancreatitis and type 2 diabetes mellitus. It was found correlations between levels of apelin, tumor necrosis factor alpha, indicators of carbohydrate, lipid metabolism and functional state of the pancreas in patients with combined pathology. Conclusions. As the result of the study there were determined basic diagnostic markers of chronic pancreatitis at type 2 diabetes mellitus: C-reactive protein, α-amilase, apelin and elastase-1. It was found the method of chronic pancreatitis prognosis in patients with type 2 diabetes mellitus.


Keywords


type 2 diabetes mellitus; chronic pancreatitis; diagnostic markers; prognosis

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DOI: https://doi.org/10.22141/2224-0721.3.67.2015.75267

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