Analysis of Height Indexes of Girls with Turner Syndrome Depending on Karyotype in Ukrainian Population

N.B. Zelinska, I.Yu. Shevchenko, N.L. Pohadaieva, Ye.V. Hloba

Abstract


Objective: to determine the parameters of stature and bone age in girls with Turner syndrome (TS) in Ukrainian population depending on the age and karyotype, the final height compared with healthy girls, as well as the state of somatotropic pituitary function in girls with TS.
Materials and methods. A retrospective analysis of 502 registration cards of girls with TS aged 11 months to 17 years inclusively has been carried out for a period from 2004 to 2014. In-depth examination was conducted in children who underwent outpatient or inpatient treatment in National children’s specialized hospital «Mother and child healthcare» and Ukrainian scientific and practical centre for endocrine surgery, transplantation of endocrine organs and tissues. We have determined physical development of a child, bone age, presence of growth failure, level of insulin-like growth factor 1 (IGF-1).
To compare growth performance of children with TS and healthy girls in the general population, we used the results of a survey of the physical development of 525 somatically healthy girls with normal female karyotype aged 10 months to 17 years inclusively (the control group).
Results. The difference in height in girls with TS and somatically healthy girls with normal female karyotype was significant (p < 0.05)
in all the age groups older than one year, increased with age, the maximum was in adolescence. The degree of growth retardation in girls with TS averages –3.1 ± 1.1 SD with maximum delay in 14 years. Bone age in girls with TS is delayed in all age groups, with a maximum difference with real age in 17 years. No significant difference in indicators of growth, bone age, level of stimulated growth hormone and IGF-1in girls with the TS with different karyotype (p > 0.05) is observed, which indicates that the karyotype formula does not affect these figures. Most of the girls with TS have a normal somatotropic function, but 35.7 % have a partial or complete deficiency of growth hormone.


Keywords


Turner syndrome; children; karyotype; height; growth retardation

References


Bondy C.A. Care of girls and women with Turner syndrome: a guideline of the Turner Syndrome Consensus Study Group // J. Clin. Endocrin. Metab. — 2007. — Vol. 92 (1). — P. 10-25.

Rappold G.A., Durand C., Decker E. еt al. New Roles of SHOX al Regulator of Target Genes // Ped. Endocrinol. Rev. — 2012. — Vol. 9 (2). — Р. 733-738.

De Lemos-Marini S.H., Morcillo A.M., Baptista M.T. et al. Spontaneous final height in Turner’s syndrome in Brazil // J. Pediatr. Endocrinol. Metab. — 2007. — Vol. 20 (11). — P. 1207-1214.

Elleuch M., Mnif Feki M., Kammoun M. et al. Descriptive analyses of Turner syndrome: 49 cases in Tunisia // Ann. Endocrinol. (Paris). — 2010. — Vol. 71(2) — P. 111-116.

Wang X.M., Yu H.J., Sun L.Y. et al. Height Standard Deviation Scoreis Related to Karyotypes and Birth Weightin Girls with Turner Syndrome // HK J. Paediatr. (new series). — 2013. — Vol. 18. — P. 24-30.

Зелинская Н.Б., Шевченко И.Ю., Щербак Ю.А., Погадаева Н.Л., Глоба Е.В. Фенотипические особенности синдрома Шерешевского — Тернера у детей Украины и их взаимосвязь с кариотипом // Педиатрия. Восточная Европа. — 2014. — № 4 (08). — С. 29-39.

Wiśniewski A., Milde K., Stupnicki R. Spontaneous growth оf girls with Turner’s syndrome until 6 years of age // Endokrynol. Diabetol. Chor. Przemiany Materii Wieku Rozw. — 2006. — Vol. 12 (1). — P. 7-11.

Schwarze C.P., Arens D., Haber H.P. et al. Bone agein 116 untreated patients with Turner’s syndrome rated by a computer-assisted method (CASAS) // Acta Paediatr. — 1998. — Vol. 87 (11). — P.1146-1150.

Наказ МОЗ № 84 від 16.02.2004 року «Про створення реєстру дітей, хворих на гіпофізарний нанізм».

Наказ МОЗ № 55 від 03.02.2009 року «Про затвердження протоколів надання медичної допомоги дітям за спеціальністю «Дитяча ендокринологія».

Наказ № 254 від 27.04.2006 року «Про затвердження протоколів надання медичної допомоги дітям за спеціальністю «Дитяча ендокринологія».

Blum W.F., Ross J.L., Zimmermann A.G. et al. GH treatment to final height produces similar height gains inpatients with SHOX deficiency and Turner syndrome: results of a multicentertrial // J. Clin. Endocrinol. Metab. — 2013. — Vol. 98 (8). — P. 1383-1392.




DOI: https://doi.org/10.22141/2224-0721.5.69.2015.75210

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© "Publishing House "Zaslavsky", 1997-2017

 

 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru