Features of Mineral Metabolism Disorders in Patients with Multinodular Goiter after Thyroidectomy

V.Ya. Kashperska

Abstract


The features of calcium, phosphorus, parathyroid hormone and vitamin D indexes in patients with multinodular non-toxic goiter after thyroidectomy are presented in the article. It is found that age over 60 years, greater thyroid volume, lower 25(ОН)D level before surgery, decline of parathyroid hormone level after surgery are the basic parameters that influence the development of hypocalcemia in patients with multinodular goiter after thyroidectomy. The level of 25(OH)D below 20 ng/ml should be regarded as a specific and sensitive preoperative predictor of hypocalcemia after thyroidectomy, as well as persistent hypoparathyroidism. The level of parathyroid hormone after surgery below 10 pg/ml can be considered as a predictor of these conditions.


Keywords


multinodular goiter; thyroidectomy; calcium; phosphorus; vitamin D

References


Мамчич В.І., Погорєлов О.В., Воскобойнік О.Ю. Хірургічне лікування щитоподібної залози: історія та перспективи подальшого вивчення (науковий огляд) // Український журнал хірургії. — 2013. — № 2(21). — С. 11-14.

Митник З.М., Данова М.П., Крушинська З.Г та ін. Стан ендокринологічної служби України в 2007 р. // Міжнародний ендокринологічний журнал. — 2008. — № 3(15). — С. 8-15.

De Sanctis V., Soliman A., Fiscina B. Hypoparathyroidism: from diagnosis to treatment // Curr. Opin. Endocrinol. Diabetes. Obes. — 2012. — Vol. 19(6). — P. 435-442. doi: 10.1097/MED.0b013e3283591502.

Tripathi M., Karwasra R.K., Parshad S. Effect of preoperative vitamin D deficiency on postoperative hypocalcemia after thyroid surgery // Thyroid Res. — 2014. — 7. — 8. Published online 2014 Dec 15. doi: 10.1186/1756-6614-7-8.

Khafif A., Pivoarov A., Medina J.E. et al. Parathyroid hormone: a sensitive predictor of hypocalcemia following total thyroidectomy // Otolaryngol Head Neck Surg. — 2006. — 134(6). — 907-910. doi: 10.1016/j.otohns.2005.12.008.

Thomusch O., Machens A., Sekulla C. et al. Multivariate analysis of risk factors for postoperative complications in benign goiter surgery: prospective multicenter study in Germany // World J. Surg. — 2000. — 24(11). — 1335-1341. doi: 10.1007/s002680010221.

Toniato A., Boschin I.M., Piotto A. et al. Thyroidectomy and parathyroid hormone: tracing hypocalcemia-prone patients // Am. J. Surg. — 2008. — 196(2). — 285-288. doi: 10.1016/j.amjsurg.2007.06.036.

Lombardi C.P., Raffaelli M., Princi P. et al. Early prediction of postthyroidectomy hypocalcemia by one single iPTH measurement // Surgery. — 2004. — 136. — 1236-1241. doi: 10.1016/j.surg.2004.06.053.

Yamashita H., Noguchi S., Murakami T. et al. Predictive risk factors for postoperative tetany in female patients with Graves’disease // J. Am. Coll. Surg. — 2001. — 192(4). — 465-468. doi: 10.1016/S1072-7515(01)00803-1.

Bellantone R., Lombardi C.P., Raffaelli M. et al. Is routine supplementation therapy (calcium and vitamin D) useful after total thyroidectomy? // Surgery. — 2002. — 132(6). — 1109-1112. doi: 10.1067/msy.2002.128617.

Weaver S., Doherty D.B., Jimenez C., Perrier N.D. Peer-reviewed, evidence-based analysis of vitamin D and primary hyperparathyroidism // World. J. Surg. — 2009. — 33(11). — 2292-2302. doi: 10.1007/s00268-009-9966-9.

Holick M.F. Vitamin D deficiency // N. Engl. J. Med. — 2007. — 357(3). — 266-281. doi: 10.1056/NEJMra070553.




DOI: https://doi.org/10.22141/2224-0721.5.69.2015.75199

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© "Publishing House "Zaslavsky", 1997-2018

 

   Seo анализ сайта