Peculiarities of Cytokine Profile in Patients with Hypothyroidism and Concomitant Chronic Cholecystitis

I.V. Prysiazhniuk, N.V. Pashkovska

Abstract


The peculiarities of cytokine regulation in patients with hypothyroidism and concomitant chronic cholecystitis and its relationship with blood biochemical parameters and lipid profile parameters were investigated. The proinflammatory IL-1β plasma level in patients in the experimental group 55.3 % (p = 0.03) prevailed in comparison with a control one. IL-1β content positively correlated with the urea concentration (r = 0.41, p = 0.04), AST (r = 0.40, p = 0.05) and ALT activities (r = 0.43, p = 0.04). In patients with hypothyroidism and chronic cholecystitis TNF-α concentration was 4.6 times (p = 0.0005) greater that in healthy individuals and 23.1 % (p = 0.04) in comparison with a comparative group of patients. A direct correlation between the TNF-α level and AST (r = 0.47, p = 0.02), ALT (r = 0.52, p = 0.01), alkaline phosphatase (r = 0.60, p = 0.002) and gamma-glutamyltransferase activities (r = 0.52, p = 0.01) was revealed. The concentration of anti-inflammatory IL-10 in the blood of patients with hypothyroidism with concomitant chronic cholecystitis was significantly lower compared to that in healthy individuals and patients with chronic cholecystitis at 56.4 % (p = 0.05) and 53.8 % (p = 0.04), respectively. There was established inverse correlation between the IL-10 content and gamma-glutamyltransferase (r = –0.44, p = 0.04), ALT activities (r = –0.39, p = 0.09), total cholesterol level (r = –0.46, p = 0.03), low density lipoproteins (r = –0.51, p = 0.01), very low density lipoproteins (r = –0.43, p = 0.04).


Keywords


chronic cholecystitis; hypothyroidism; inteleukin 1β; tumor necrosis factor α; interleukin 10

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DOI: https://doi.org/10.22141/2224-0721.5.69.2015.75197

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