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The peculiarities of cytokine regulation in patients with hypothyroidism and concomitant chronic cholecystitis and its relationship with blood biochemical parameters and lipid profile parameters were investigated. The proinflammatory IL-1β plasma level in patients in the experimental group 55.3 % (p = 0.03) prevailed in comparison with a control one. IL-1β content positively correlated with the urea concentration (r = 0.41, p = 0.04), AST (r = 0.40, p = 0.05) and ALT activities (r = 0.43, p = 0.04). In patients with hypothyroidism and chronic cholecystitis TNF-α concentration was 4.6 times (p = 0.0005) greater that in healthy individuals and 23.1 % (p = 0.04) in comparison with a comparative group of patients. A direct correlation between the TNF-α level and AST (r = 0.47, p = 0.02), ALT (r = 0.52, p = 0.01), alkaline phosphatase (r = 0.60, p = 0.002) and gamma-glutamyltransferase activities (r = 0.52, p = 0.01) was revealed. The concentration of anti-inflammatory IL-10 in the blood of patients with hypothyroidism with concomitant chronic cholecystitis was significantly lower compared to that in healthy individuals and patients with chronic cholecystitis at 56.4 % (p = 0.05) and 53.8 % (p = 0.04), respectively. There was established inverse correlation between the IL-10 content and gamma-glutamyltransferase (r = –0.44, p = 0.04), ALT activities (r = –0.39, p = 0.09), total cholesterol level (r = –0.46, p = 0.03), low density lipoproteins (r = –0.51, p = 0.01), very low density lipoproteins (r = –0.43, p = 0.04).
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