Associated Changes in Hormonal Status and Skeletal Muscular Tissue in Elderly Female Patients

V.V. Povorozniuk, N.I. Dzerovych


The paper presents the reasons of sarcopenia development in elderly patients — a syndrome with typical progressive and generalized decrease of skeletl muscular mass, strength, and functioning. There is a literature review about growth hormone impact on skeletal muscular tissue as well as the results of the study conducted on the base of the SI «Institute of Gerontology named after D.I. Chebotariov of NAMS of Ukraine». The aim of the study was to investigate the correlation between the parameters of skeletal muscles and growth hormone level, general and free testosterone. The state of fat-free mass of the body, lower and upper extremities was estimated by the means of two-photon absorptiometry (Prodigy, GEHC Lunar, Madison, WI, USA). The strength of skeletal muscles was assessed by hand-grip springy myodynometer the patient compresses with the grip of outstretched arm. Walking space was estimeated by the 4-meter test in the purpose to determine functional capacity of skeletal muscles. Blood serum levels of generalized and free testosterone and growth hormone were determined by the immunochemiluminometric assay using Immulite 2000 of Siemens DPC (USA). The study results demonstrated the correlation between the growth hormone and appendicular fat-free mass; levels of generalized and free testosterone and growth hormone with skeletal muscles strength; levels of generalized and free testosterone and functional capacity of skeletal muscular tissue.


skeletal muscular tissue; mass; strength; functioning; hormones; growth hormone; estrogen; testosterone; age; women


Поворознюк В.В. Захворювання кістково-м’язової системи в людей різного віку (вибрані лекції, огляди, статті): в 3 т. — К., 2009. — С. 664.

Bea J.W., Zhao O., Cauley J.A. et al. Effect of hormone therapy on lean body mass, falls, and fractures: Six-year results from the Women’s Health Initiative Hormone Trials // Menopause. — 2011. — Vol. 18(1). — P. 44-52.

Budul S.L., Rossi A.P., Zamboni M. The pathogenic bases of sarcopenia. Mini-review // The clinical cases in mineral and bone metabolism. — 2015. — Vol. 12(1). — P. 22-26.

Christiansen J.J., Andersen N.H., Sоrensen K.E. et al. Dehydroepiandrosterone substitution in female adrenal failure: no impact on endothelial function and cardiovascular parameters despite normalization of androgen status // Clin. Endocrinol. (Oxf). — 2007. — Vol. 66(3). — P. 426-433.

Cruz-Jentoft A.J., Baeyens J.P., Bauer J.M et al. Sarcopenia: European consensus on definition and diagnosis // Age and ageing. — 2010. — Vol. 39. — P. 412-423.

Horstman A.M., Dillon E.L., Urban R.J., eld-Moore M.Sh. The role of androgens and estrogens on healthy aging and longe-vity // Journals of Gerontology: Biological Sciences Cite journal. — 2012. — Vol. 67(11). — Р. 1140-1152.

Hwang A.C., Liu L.K., Lee W.J. et al. Association of androgen with skeletal muscle mass and muscle function among men and women aged 50 years and older in Taiwan: results from the I-Lan longitudinal aging study // Rejuvenation Res. — 2013. — Vol. 16(6). — P. 453-459.

Messier V., Rabasa-Lhoret R., Barbat-Artigas S. et al. Menopause and sarcopenia: a potential role for sex hormones // Maturitas. — 2011. — Vol. 68. — P. 331-336.

Perrini S., Laviola L., Carreira M.C. The GH/IGF1 axis and signaling pathways in the muscle and bone: mechanisms underlying age-related skeletal muscle wasting and osteoporosis // Journal of Endocrinology. — 2010. — Vol. 205. — Р. 201-210.

Sakuma K., Yamaguchi A. Sarcopenia and age-related endocrine function. Review article. // International journal of endocrinology. — 2012. — Article ID 127362, 10 pages, doi: 10.1155/2012/127362.

Smith G.I., Yoshino J., Reeds D.N. et al. Testosterone and progesterone, but not estradiol, stimulate muscle protein synthesis in postmenopausal women // J. Clin. Endocrinol. Metab. — 2014. — Vol. 99(1). — P. 256-265.

Velloso C.P. Regulation of muscle mass by growth hormone and IGF-I // Br. J. Pharmacol. — 2008. — Vol. 154(3). — P. 557-568.

Yuki A., Ando F., Otsuka R., Shimokata H. Low free testosterone is associated with loss of appendicular muscle mass in Japanese community-dwelling women // Geriatr. Gerontol. Int. — 2015. — Vol. 15(3). — P. 326-333.

Yuki A., Otsuka R., Kozakai R. et al. Relationship between Low free testosterone levels and loss of muscle mass. — 2013. — Scientific Reports 3, Article number: 1818 doi:10.1038/srep01818.

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