Associated Changes in Hormonal Status and Skeletal Muscular Tissue in Elderly Female Patients

V.V. Povorozniuk, N.I. Dzerovych


The paper presents the reasons of sarcopenia development in elderly patients — a syndrome with typical progressive and generalized decrease of skeletl muscular mass, strength, and functioning. There is a literature review about growth hormone impact on skeletal muscular tissue as well as the results of the study conducted on the base of the SI «Institute of Gerontology named after D.I. Chebotariov of NAMS of Ukraine». The aim of the study was to investigate the correlation between the parameters of skeletal muscles and growth hormone level, general and free testosterone. The state of fat-free mass of the body, lower and upper extremities was estimated by the means of two-photon absorptiometry (Prodigy, GEHC Lunar, Madison, WI, USA). The strength of skeletal muscles was assessed by hand-grip springy myodynometer the patient compresses with the grip of outstretched arm. Walking space was estimeated by the 4-meter test in the purpose to determine functional capacity of skeletal muscles. Blood serum levels of generalized and free testosterone and growth hormone were determined by the immunochemiluminometric assay using Immulite 2000 of Siemens DPC (USA). The study results demonstrated the correlation between the growth hormone and appendicular fat-free mass; levels of generalized and free testosterone and growth hormone with skeletal muscles strength; levels of generalized and free testosterone and functional capacity of skeletal muscular tissue.


skeletal muscular tissue; mass; strength; functioning; hormones; growth hormone; estrogen; testosterone; age; women


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