DOI: https://doi.org/10.22141/2224-0721.4.68.2015.75011

Dynamics of Carbohydrate and Lipid Metabolic Parameters under Complex Therapy in Patients with Type 2 Diabetes Mellitus Combined with Primary Hypothyroidism

T.Yu. Yuzvenko

Abstract


The aim of work was to study dynamics of carbohydrate and lipid metabolic parameters under complex therapy in patients with the type 2 diabetes mellitus (DM) combined with primary hypothyroidism. 173 persons (26 men and 147 women) were examined. The first (basic) group consisted of 52 patients with  type 2 DM combined with primary hypothyroidism. The second group was formed with 55 patients with type 2 DM without thyroid pathology, the third group included 48 patients with primary hypothyroidism without DM (groups of comparison). In the group of type 2 DM patients with primary hypothyroidism in 4 and 12 weeks of complex therapy there were found the improvement of indexes of fasting glucose, postprandial glycemia and glycated haemoglobin, and there was compensation of hypothyroidism in 12 weeks. In patients with the combined pathology there were registered more severe violations of lipid metabolism as an increased values of triglycerides, total holesterol, declined high density lipoproteins, than in the groups of comparison. Under a complex therapy the positive dynamics of lipid spectrum is educed as a declined level of total holesterol, low density lipoproteins, atherogenic coefficient. Levels of total holesterol, triglycerides, atherogenic coefficient positively correlate with the level of thyreotrophin in primary hypothyroidism.


Keywords


type 2 diabetes mellitus; hypothyroidism; lipid metabolism; treatment

References


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