The Importance of Clinical and Diagnostic Markers of Aggression of Non-Functional Pituitary Adenomas

Main Article Content

Yu.M. Urmanova
Z.Yu. Khalimova
R.B. Faizullaev
M.Yu. Shakirova
D.Sh. Kholova


Sixty patients with non-functional pituitary adenomas were observed. Most patients had large-cell chromophobe pituitary adenomas (81.6%). Small-cell chromophobe adenomas occurred in 10 % cases. Only 1 patient (3.3 %) had giant carcinoma with regrowth and metastasis into the brain. Markers of aggression of non-functional pituitary adenomas are the young age of a patient, expressed first symptoms of disease manifestation, large size of tumor, asymmetry and deformation of pituitary, invasion of tumor to the neighboring tissues/arteries/cavernous sinus, presence of small cell and dark-cell chromophobe adenoma, panhypopituitarism.

Article Details

How to Cite
Urmanova, Y., Z. Khalimova, R. Faizullaev, M. Shakirova, and D. Kholova. “The Importance of Clinical and Diagnostic Markers of Aggression of Non-Functional Pituitary Adenomas”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), no. 6.70, Nov. 2015, pp. 24-27, doi:10.22141/2224-0721.6.70.2015.72634.
Original Researches


Булатов А.А. Современная концепция патогенеза опухолей гипофиза // Проблемы эндокринологии. — 2000. — № 1. — С. 26-29.

Урманова Ю.М., Шакирова М.Ю., Алиева Д.А. Функциональное состояние системы «гипофиз — гонады» у мужчин с неактивными аденомами гипофиза и дефицитом гормона роста у взрослых // Международный эндокринологический журнал. — 2014. — № 3. — С. 56-61.

Cury M.L., Fernandes J.C., Machado H.R. Non-functioning pituitary adenomas: clinical feature, laboratorial and imaging assessment, therapeutic management and outcome // Arq. Bras. Endocrinol. Metabol. — 2009. — Vol. 53(1). — P. 31-39.

Ragel B.T., Couldwell W.T. Pituitary carcinoma: a review of the literature // Neurosurg Focus. — 2004. — Vol. 16(4). — P. 7-11.

Sibal I. Pituitary apoplexy: a review of clinical presentation, management and outcomes // Pituitary. — 2005. — № 1. —

P. 157-163.

Most read articles by the same author(s)

1 2 3 4 5 > >>