The Importance of Clinical and Diagnostic Markers of Aggression of Non-Functional Pituitary Adenomas

Authors

  • Yu.M. Urmanova Tashkent Pediatric Medical Institute; Specialized Research and Practice Medical Center of Endocrinology, Ministry of Health of Republic of Uzbekistan, Tashkent
  • Z.Yu. Khalimova Tashkent Pediatric Medical Institute; Specialized Research and Practice Medical Center of Endocrinology, Ministry of Health of Republic of Uzbekistan, Tashkent
  • R.B. Faizullaev Tashkent Pediatric Medical Institute; Specialized Research and Practice Medical Center of Endocrinology, Ministry of Health of Republic of Uzbekistan, Tashkent
  • M.Yu. Shakirova Tashkent Pediatric Medical Institute; Specialized Research and Practice Medical Center of Endocrinology, Ministry of Health of Republic of Uzbekistan, Tashkent
  • D.Sh. Kholova Tashkent Pediatric Medical Institute; Specialized Research and Practice Medical Center of Endocrinology, Ministry of Health of Republic of Uzbekistan, Tashkent

DOI:

https://doi.org/10.22141/2224-0721.6.70.2015.72634

Keywords:

non-functional pituitary adenomas, markers of aggression

Abstract

Sixty patients with non-functional pituitary adenomas were observed. Most patients had large-cell chromophobe pituitary adenomas (81.6%). Small-cell chromophobe adenomas occurred in 10 % cases. Only 1 patient (3.3 %) had giant carcinoma with regrowth and metastasis into the brain. Markers of aggression of non-functional pituitary adenomas are the young age of a patient, expressed first symptoms of disease manifestation, large size of tumor, asymmetry and deformation of pituitary, invasion of tumor to the neighboring tissues/arteries/cavernous sinus, presence of small cell and dark-cell chromophobe adenoma, panhypopituitarism.

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Published

2015-11-19

Issue

Section

Original Researches