The Importance of Clinical and Diagnostic Markers of Aggression of Non-Functional Pituitary Adenomas

Yu.M. Urmanova, Z.Yu. Khalimova, R.B. Faizullaev, M.Yu. Shakirova, D.Sh. Kholova


Sixty patients with non-functional pituitary adenomas were observed. Most patients had large-cell chromophobe pituitary adenomas (81.6%). Small-cell chromophobe adenomas occurred in 10 % cases. Only 1 patient (3.3 %) had giant carcinoma with regrowth and metastasis into the brain. Markers of aggression of non-functional pituitary adenomas are the young age of a patient, expressed first symptoms of disease manifestation, large size of tumor, asymmetry and deformation of pituitary, invasion of tumor to the neighboring tissues/arteries/cavernous sinus, presence of small cell and dark-cell chromophobe adenoma, panhypopituitarism.


non-functional pituitary adenomas; markers of aggression


Булатов А.А. Современная концепция патогенеза опухолей гипофиза // Проблемы эндокринологии. — 2000. — № 1. — С. 26-29.

Урманова Ю.М., Шакирова М.Ю., Алиева Д.А. Функциональное состояние системы «гипофиз — гонады» у мужчин с неактивными аденомами гипофиза и дефицитом гормона роста у взрослых // Международный эндокринологический журнал. — 2014. — № 3. — С. 56-61.

Cury M.L., Fernandes J.C., Machado H.R. Non-functioning pituitary adenomas: clinical feature, laboratorial and imaging assessment, therapeutic management and outcome // Arq. Bras. Endocrinol. Metabol. — 2009. — Vol. 53(1). — P. 31-39.

Ragel B.T., Couldwell W.T. Pituitary carcinoma: a review of the literature // Neurosurg Focus. — 2004. — Vol. 16(4). — P. 7-11.

Sibal I. Pituitary apoplexy: a review of clinical presentation, management and outcomes // Pituitary. — 2005. — № 1. —

P. 157-163.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© "Publishing House "Zaslavsky", 1997-2019


   Seo анализ сайта