Profile of Cardiovascular Risk Factors in Patients with Coronary Heart Disease, Normal and Impaired Carbohydrate Metabolism
The aim of research was to conduct the comparative analysis of the profile of cardiovascular risk factors in patients with coronary heart disease (CHD) and normal either impaired carbohydrate metabolism. Materials and methods. One hundred and forty two patients were observed. In order to estimate the rate of different forms of CHD depending on the state of carbohydrate metabolism such groups were formed: the first group consisted of 83 patients with type 2 diabetes mellitus (DM), the second group involved 34 patients with impaired glucose tolerance (IGT), the third group consisted of 25 patients with normal carbohydrate metabolism. The ischemic changes of myocardium were detected by ambulatory ECG monitoring with the obligatory achievement of submaximal heart rate during the research. Results. Silent myocardial ischemia was educed in 19 (22.9 %) patients with type 2 DM, in 3 (8.8 %) persons with IGT and in 2 (8.0 %) patients with normal carbohydrate metabolism. Smoking, burdened heredity, violation in the haemostatic system more often occurred in the group of patients with type 2 DM and silent myocardial ischemia in comparison with the patients with type 2 DM without CHD. The profile of general population cardiovascular risk factors in patients with CHD and type 2 DM belongs to the most unfavorable. At the same time for patients with early violations of carbohydrate metabolism and normal carbohydrate metabolism such profile statistically does not differentiate meaningfully. Conclusions. Patients with type 2 DM and silent myocardial ischemia as compared to patients with type 2 DM without CHD have more expressed violations of indexes of general population cardiovascular risk factors for certain.
Diabetes Atlas, IDF, 7th ed., 2015.
Bulugahapitiya U, Siyambalapitiya S, Sithole J, Idris I. Is diabetes a coronary risk equivalent? Systematic review and meta-analysis. Diabet. Med. 2009; 26; 142-8. doi: 10.1111/j.1464-5491.2008.02640.x.
Timbie JW, Hayward RA, Vijan S. Variation in the net benefit of aggressive cardiovascular risk factor control across the US population of patients with diabetes mellitus. Arch. Intern. Med. 2010; 170: 1037-44. doi: 10.1001/archinternmed.2010.150.
Wannamethee SG, Shaper AG, Whincup PH. Impact of diabetes on cardiovascular disease risk and all-cause mortality in older men: influence of age at onset, diabetes duration, and established and novel risk factors. Arch. Intern. Med. 2011; 171: 404-10. doi: 10.1001/archinternmed.2011.2.
Rydén L, Grant PJ, Anker SD. ESC guidelines on diabetes, prediabetes, and cardiovascular diseases developed in collaboration with the EASD: the Task Force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD). Eur. Heart J. 2013; 34: 3035-87. doi: 10.1093/eurheartj/eht108.
Rodriguez-Poncelas A, Coll-de-Tuero G, Saez M. Comparison of different vascular risk engines in the identification of type 2 diabetes patients with high cardiovascular risk. BMC Cardiovasc. Disord. 2015; 15(1): 121. doi: 10.1186/s12872-015-0120-3.
Shah AD, Langenberg C, Rapsomaniki E. Type 2 diabetes and incidence of a wide range of cardiovascular diseases: a cohort study in 1.9 million people. Lancet. 2015; 26 (385): 86. doi: 10.1016/S0140-6736(15)60401-9.
Seshasai SR, Kaptoge S, Thompson A. Diabetes mellitus, fasting glucose, and risk of cause-specific death. The Emerging risk factors collaboration. N. Engl J. Med. 2011; 364: 829-84. doi: 10.1056/NEJMoa1008862.
This work is licensed under a Creative Commons Attribution 4.0 International License.
© "Publishing House "Zaslavsky", 1997-2018