Main Article Content
Introduction. In this article, the authors present the results of studies on reproductive health features in 25 women with obesity seeking medical help for infertility. Objective: to study the nature of menstrual disorders in women of childbearing age with obesity. Materials and methods. We have studied the features of reproductive health in 25 obese women seeking medical assistance for infertility in the Republican specialized scientific and practical centre of endocrinology in 2014–2015, who were included in the first study group. The second group consisted of 25 women with normal weight-for-stature values and without menstrual disorders. All the patients underwent the following tests, including complete blood count, blood biochemistry, radioimmunoassays of the blood hormones (prolactin, luteinizing hormone (LH), follicle stimulating hormone (FSH), insulin, estradiol, progesterone, free testosterone, thyroxine, anti-Műllerian hormone, dehydroepiandrostenedione, ultrasound of the uterus and ovaries with folliculometry on 11–14th days of the menstrual cycle. All patients underwent magnetic resonance imaging of the pituitary gland. Results. In the history of the patients in both groups, diseases of the upper respiratory tract and gastrointestinal diseases were most common among somatic pathology. Among gynecological diseases, in both groups the most frequent disorders were chronic urogenital infection, candida vaginitis and bacterial vaginosis. Emphasis is placed on the data about the presence of hormone-dependent proliferative diseases in women with overweight: cervical pseudoerosions, endocervicosis, uterine fibroids, a history of endometriosis. The analysis of biochemical parameters in the first study group found increased triglycerids levels < 1.7 mmol/L in 15 %, a decrease in high-density lipoprotein cholesterol < 1.2 mmol/l — in 12 % of women, increased levels of low-density lipoprotein cholesterol > 3.0 mmol/L — in 34 %. The first group of patients had low values of the average parameters of LH, FSH, free and total testosterone (normogonadotropic hypogonadism) against normoprolactinemia. The levels of adrenocorticotropic hormone, thyroid-stimulating hormone, free thyroxine, and cortisol were within normal limits. Folliculometry results showed a high incidence of follicular persistence, anovulatory disorders and follicular atresia. Conclusions. In young women with the metabolic syndrome, secondary amenorrhea prevails in the structure of menstrual dysfunction — 8 (32.0 %) cases. Hyperandrogenic anovulation following hyperinsulinemia underlies the menstrual dysfunction.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our edition uses the copyright terms of Creative Commons for open access journals.
Authors, who are published in this journal, agree with the following terms:
- The authors retain rights for authorship of their article and grant to the edition the right of first publication of the article on a Creative Commons Attribution 4.0 International License, which allows others to freely distribute the published article, with the obligatory reference to the authors of original works and original publication in this journal.
- Directing the article for the publication to the editorial board (publisher), the author agrees with transmitting of rights for the protection and using the article, including parts of the article, which are protected by the copyrights, such as the author’s photo, pictures, charts, tables, etc., including the reproduction in the media and the Internet; for distributing; for the translation of the manuscript in all languages; for export and import of the publications copies of the writers’ article to spread, bringing to the general information.
- The rights mentioned above authors transfer to the edition (publisher) for the unlimited period of validity and on the territory of all countries of the world.
- The authors guarantee that they have exclusive rights for using of the article, which they have sent to the edition (publisher). The edition (the publisher) is not responsible for the violation of given guarantees by the authors to the third parties.
- The authors have the right to conclude separate supplement agreements that relate to non-exclusive distribution of their article in the form in which it had been published in the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
- The policy of the journal permits and encourages the publication of the article in the Internet (in institutional repository or on a personal website) by the authors, because it contributes to productive scientific discussion and a positive effect on efficiency and dynamics of the citation of the article.
Исмаилов С.И., Урманова Ю.М., Набиева И.Ф. Оценка гипоталамо-гипофизарно-гонадной оси у мужчин с метаболическим синдромом и андродефицитом в зависимости от возраста (обзор литературы) // Международный эндокринологический журнал. — 2012. — № 1.
Boney C.M., Verma A., Tucker R. et al. Metabolic syndrome in childhood: association with birth weight, material obesity and gestational diabetes mellitus // Pediatrics. — 2005. — Vol. 116 (2). — P. 519.
Kiess W., Galler A., Reich A. et al. Clinical aspects of obesity in childhood and adolescence // Obes. Rev. — 2001. — Vol. 2. — P. 29-36.
Kiessling S.G., McClanahan K.K., Omar H.A. Obesity, hypertension and mental health evaluation in adolescents: a comprehensive approach // Int. J. Adolesc. Med. Health. — 2008. — Vol. 20. — P. 5-15.
Hollmann M. Effects of weight loss on the hormonal profile in obese infertile women // Human reproduction. — 1996. — Vol. 11. — Р. 1884-1891.