Insulin Toujeo® — a Novel Basal Long-Acting Insulin Formulation. Part 2. Clinical Efficacy and Safety

V.V. Poltorak, N.А. Kravchun, M.Yu. Gorshunska

Abstract


This review, consisting of two parts, considers a new formulation of insulin glargine (rDNA origin) in the form of injections 300 U/ml (Gla-300, Toujeo®). Gla-300 is a next generation basal insulin with a novel formulation of insulin glargin delivering the same amount of insulin, as glargine-100 (Gla-100) in 1/3 volume. Following the subcutaneous injection, pharmacokinetic and pharmacodynamic profiles of Gla-300 are more constant and prolonged (beyond 24 hours) compared with Gla-100 due to a more gradual and extended release of glargine from subcutaneous depot (Gla-300 forms a more compact subcutaneous depot with reduced surface area compared to Gla-100). The clinical efficacy and safety of Gla-300 in patients with type 1 and type 2 diabetes mellitus are discussed with an emphasis on recently released data from EDITION (the phase 3a) clinical trials. Gla-300 showed comparable glycaemic control and similar safety profile with lower incidence of hypoglycaemia events compared with Gla-100. Gla-300 provided flexible dosing of insulin (24 ± 3 h or morning vs evening) and was associated with less body weight gain.


Keywords


diabetes mellitus; glycated hemoglobin; hypoglycaemia; glargine; insulin; Gla-100; Gla-300 (Toujeo®)

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DOI: https://doi.org/10.22141/2224-0721.8.72.2015.72337

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