Hyperplastic Processes of the Thyroid Gland in Type 2 Diabetic Patients Who Suffered from the Chornobyl Disaster

I.M. Muraviova, I.H. Chykalova

Abstract


To study the clinical correlations between diabetes mellitus (DM) type 2 and hyperplastic processes of the thyroid gland (TG), we conducted a survey of the participants of Chernobyl accident consequences elimination — 125 men aged 61.95 ± 0.66 years and 24 women aged 62.13 ± 1.34 years (group I), evacuees — 6 men aged 56.00 ± 6.45 years and 18 women aged 58.56 ± 2.07 years (group II), residents of contaminated territories — 32 men aged 59.69 ± 2.13 years and 67 women aged 58.39 ± 1.23 years (group III). The control group consisted of Kyiv residents — 18 men aged 59.00 ± 2.45 years and 34 women aged 57.88 ± 2.61 years diagnosed with DM type 2 and pathology of the TG. Results. The incidence of hyperplastic processes of the TG in patients with DM type 2, who suffered from the disaster, was higher among women (79.2 %) than among men — 45.6 % (χ2 = 9.078; p = 0.003), similarly to the group control — 55.9 and 16.7 %, respectively (χ2 = 7.415; p = 0.007), it was significantly higher among male victims of the accident than in the control group (χ2 = 5.41; p = 0.02). We had established a strong direct correlation between the level of thyroid stimulating hormone (TSH) and body mass index (BMI) (r = 0.799; p = 0.031), glycated hemoglobin (r = 0.999; p = 0.027) among men in the control group. During multivariate analysis, we have found the probable model of the duration of DM type 2 and development of hyperplastic processes in the TG (F = 6.6947; p = 0.00022) and its absence for other indicators, namely: BMI (F = 1.7351; p = 0.15969), TSH (F = 0.29968; p = 0.82559), the C-peptide (F = 0.09665; p = 0.96160) and glycated hemoglobin (F = 0.17955; p = 0.90996). Conclusions. In patients with DM type 2, who suffered from the Chornobyl disaster, the incidence of hyperplastic processes in the TG statistically significantly exceeds the rate in unirradiated individuals and depends on the gender, duration of the underlying disease and its decompensation.


Keywords


thyroid gland; diabetes mellitus; those who suffered from the Chornobyl disaster.

References


Larin O.S. Analiz diyal'nosti endokrynolohichnoyi sluzhby Ukrayiny u 2010 rotsi ta perspektyvy rozvytku medychnoyi dopomohy khvorym z endokrynnoyu patolohiyeyu / O.S. Larin, V.I. Pankiv, M.I. Selivanenko ta insh. // Mizhnarodnyy endokrynolohichnyy zhurnal. – 2011. - # 3 (35). – S. 10-18.

Pan'kiv V.I. Vzayemozv"yazky mizh strukturno-funktsional'nymy porushennyamy shchytopodibnoyi zalozy i komponentamy metabolichnoho syndromu / V.I. Pankiv, V.M. Havrylyuk, L.D. Neporadna ta insh. // Mizhnarodnyy endokrynolohichnyy zhurnal. – 2011. - # 6 (38). – S. 1-6.

Pan'kiv V.I. Vzayemozv"yazok mizh patolohiyeyu shchytopodibnoyi zalozy i tsukrovym diabetom 2 typu / V.I. Pan'kiv // Zdorov"ya Ukrayiny. – 2013. – # 2 (22). – S. 36-37.

Krutykov E.S. Strukturno-funktsyonal'nye narushenyya shchytovydnoy zhelezy u bol'nykh sakharnym dyabetom 2-ho typa / E.S. Krutykov, V.A. Tsvetkov, A.S. Hlushko // Tavrycheskyy medyko-byolohycheskyy vestnyk. – 2013. – T. 16, # 3. – S. 71–74.

Bobryk M.I. Vzaymnoe vlyyanye tyreoydnoho y uhlevodnoho obmena. Paradyhmy y paradoksy / M.I. Bobryk // Mizhnarodnyy endokrynolohichnyy zhurnal. – 2015. – # 3 (67). – S. 127-132.

Ysmaylov S.I. Vzaymosvyaz' sakharnoho dyabeta y tyreoydnoy patolohy (obzor lyteratury) / S.I. Ysmaylov, Hulyamova Kh.R., Akhmedova Sh.U. y dr. // Mizhnarodnyy endokrynolohichnyy zhurnal. – 2015. – # 3 (67). – S. 148-152.

Yuzvenko T.Y. Chastota strukturnykh porazhenyy shchytovydnoy zhelezy u bol'nykh sakharnym diabetom 2-ho typa / T.Y. Yuzvenko // Mizhnarodnyy endokrynolohichnyy zhurnal. – 2015. – # 1 (65). – S. 19-22.

Yuzvenko T.Y. Osoblyvosti funktsional'noho stanu shchytopodibnoyi zalozy u khvorykh na tsukrovyy diabet 2-ho typu z ozhyrinnyam / T.Y. Yuzvenko // Mizhnarodnyy endokrynolohichnyy zhurnal. – 2015. – # 2 (66). – S. 25-28.




DOI: https://doi.org/10.22141/2224-0721.1.73.2016.71102

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© "Publishing House "Zaslavsky", 1997-2017

 

 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru