Snps Gln27Glu Polymorphism of β2-Adrenoceptor Gene and Carbohydrate and Lipid Metabolism Impairment in Obese Patients with Ischemic Heart Disease

Main Article Content

O.I. Kadykova

Abstract

This article estimates the role of Gln27Glu polymorphism of β2-adrenergic receptors gene in forming violations of carbohydrate and lipid metabolism in obese patients with ischemic heart disease.
A comprehensive survey of 222 patients with ischemic heart disease and obesity was conducted. The study determined the carbohydrate, lipid metabolism and gene allelic polymorphism of Gln27Glu of β2-adrenergic receptors gene.
Comorbidity of ischemic heart disease and obesity is characterized by hyperinsulinemia and insulin resistance on the background of normoglycemia that is associated with the G/G genotype polymorphism of Gln27Glu of β2-adrenergic receptors gene. G/G genotype polymorphism gene of Gln27Glu β2-adrenergic receptors in patients with ischemic heart disease is associated with increased body mass index and triglyceride levels.
In our study, we provided evidence of the influence of genotype G/G of Gln27Glu polymorphism of β2-adrenergic receptors gene in patients with ischemic heart disease and obesity on carbohydrate and lipid metabolism. Homozygotes (G/G) had elevated insulin levels, insulin resistance, body mass index and triglycerides.

Article Details

How to Cite
Kadykova, O. “Snps Gln27Glu Polymorphism of β2-Adrenoceptor Gene and Carbohydrate and Lipid Metabolism Impairment in Obese Patients With Ischemic Heart Disease”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), no. 1.73, Mar. 2016, pp. 92-96, doi:10.22141/2224-0721.1.73.2016.71096.
Section
Original Researches

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