Snps Gln27Glu Polymorphism of β2-Adrenoceptor Gene and Carbohydrate and Lipid Metabolism Impairment in Obese Patients with Ischemic Heart Disease

O.I. Kadykova

Abstract


This article estimates the role of Gln27Glu polymorphism of β2-adrenergic receptors gene in forming violations of carbohydrate and lipid metabolism in obese patients with ischemic heart disease.
A comprehensive survey of 222 patients with ischemic heart disease and obesity was conducted. The study determined the carbohydrate, lipid metabolism and gene allelic polymorphism of Gln27Glu of β2-adrenergic receptors gene.
Comorbidity of ischemic heart disease and obesity is characterized by hyperinsulinemia and insulin resistance on the background of normoglycemia that is associated with the G/G genotype polymorphism of Gln27Glu of β2-adrenergic receptors gene. G/G genotype polymorphism gene of Gln27Glu β2-adrenergic receptors in patients with ischemic heart disease is associated with increased body mass index and triglyceride levels.
In our study, we provided evidence of the influence of genotype G/G of Gln27Glu polymorphism of β2-adrenergic receptors gene in patients with ischemic heart disease and obesity on carbohydrate and lipid metabolism. Homozygotes (G/G) had elevated insulin levels, insulin resistance, body mass index and triglycerides.


Keywords


Gln27Glu polymorphism of β2-adrenergic receptors gene; ischemic heart disease; obesity; carbohydrate and lipid metabolism.

References


Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association scientific statement on obesity and heart disease from the obesity committee of the council on nutrition, physical activity, and metabolism. / P. Poirier, TD. Giles, GA. Bray et al. Circulation. 2006;113: 898-918.

Beta-1 and beta-2 adrenoreceptor polymorphisms: functional impotance, impact on cardiovascular disease and drug responses. OE. Brodde. Pharmacol Ther. 2008; 117:1-29.

Beta-2 adrenoceptor polymorphism determines vascular reactivity in humans / JR. Cockcroft, AG. Gazis, DJ. Cross et al. Hypertension. 2000;36:371-75.

Beta2-adrenergic receptor genotypes and haplotypes in different ethnic groups. / TJ. Maxwell, MM. Ameyaw, S Pritchard. Int J Mol Med. 2005;16:573-80.

Role of beta(2)-adrenergic receptor polymorphisms on body weight and body composition response to energy restriction in obese women: preliminary results. Ruiz JR, Larrarte E, Margareto J, Ares R, Labayen I. Obesity (Silver Spring). 2011;19:212-15.

Association of ADRB2 polymorphism with triglyceride levels in Tongans. / Naka IOJ, Kimura R, Inaoka T, Matsumura Y. Lipids in Health and Disease. 2013;12:1-5.

Association of polymorphism in the β2-adrenergic receptor gene with obesity, hypertriglyceridemia, and diabetes mellitus. Ishiyama-Shigemoto S, Yamada K, Yuan X, Nonaka K. Diabetologia. 1999; 42: 98-101.

Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function. V. Large, L Hellstrom, S Reynisdottir et al. J Clin Invest. 1997; 100: 3005-12.

The different effects of Gln27Glu β2-adrenoceptor gene polymorphism on obesity in males and in females. Hellstrom L, Large V, Reynisdottir S, Wahrenberg H, Arner P. J Intern Med. 1999; 245: 253-9.

Gln27Glu variant of Beta 2-adrenoreceptor gene affects male type fat accumulation in women. Kunnas T, Lachitioo R, Kortelainen MJ, Kalela A, Nikkari ST. Lipids in Health and Disease. 2009;43:1-4.

β2-adrenoceptor polymorphisms relate to obesity through blunted leptin mediated sympathetic activation. K Masuo, T Katsuya, H Kawaguchi et al. Am J Hypertens. 2006; 19: 1084-91.

The Gln27Glu β2-adrenergic receptor variant is associated with obesity due to subcutaneous fat accumulation in Japanese men. Y Mori, H Kim-Motoyama, Y Ito et al. Biochem Biophys Res Commun. 1999; 258: 138-40.

Gln27Glu and Arg16Gly polymorphisms of the beta2-adrenergic receptor gene are not associated with obesity in Japanese men. T Hayakawa, Y Nagai, T Kahara et al. Metabolism. 2000; 49: 1215-18.

Lack of association between a human beta2-adrenoceptor gene polymorphism (gln27glu) and morbid obesity. Kortner B, Wolf AM, Wendt D, Beisiegel U, Evans D. Int J Obes Relat Metab Disord. 2000; 23: 1099-100.

The Gln27Glu polymorphismin the beta2-adrenergic receptor gene is not associated with morbid obesity in Austrian women. H Oberkofler, H Esterbauer, E Hell. Int J Obes Relat Metab Disord. 2000; 24:388-90.




DOI: https://doi.org/10.22141/2224-0721.1.73.2016.71096

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