Effect of Metformin Therapy on the Levels of Folic Acid and Homocysteine in Women with Polycystic Ovary Syndrome

Main Article Content

Yu.I. Karachentsev
T.L. Arkhypkina
L.P. Liubymovа
V.O. Bondarenko


The article presents the data on the effect of metformin monotherapy and combination therapy with metformin and addition of folate on the levels of homocysteine and folic acid in patients with polycystic ovary syndrome. Monotherapy has lead to a reduction of insulin resistance, HOMA index, moderate antiandrogen effect, had a positive effect on lipid levels, while level of folic acid remained low, and the concentration of homocysteine in the blood serum increased by 18.3 %. Combination therapy didn’t increase the therapeutic effect on carbohydrate metabolism and hormonal parameters, but lead to an increase in folate content by 12.4 % and reduced the levels of homocysteine by 14.3 % in comparison with baseline ones.

Article Details

How to Cite
Karachentsev, Y., T. Arkhypkina, Liubymovа L., and V. Bondarenko. “Effect of Metformin Therapy on the Levels of Folic Acid and Homocysteine in Women With Polycystic Ovary Syndrome”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), no. 1.73, Mar. 2016, pp. 81-86, doi:10.22141/2224-0721.1.73.2016.71076.
Original Researches


Caserta D, Adducchio G, Picchia S, et al. Gynecol Endocrinol 2014; 30(6): 347-402.

Diamanti-Kandarakis Е, Dunaif А. Endocrin Rev 2012; 33 (6): 981-1030.

Marshall JC, Dunaif A. Fertil Steril 2012; 97(1): 18-22.

Bertoldo M, Faure M, Dupont J, Froment P. Ann Transl Med 2014; 2(6): 1-33.

Diamanti-Kandarakis E, Economou F, Palimeri S, Christakou C. Ann N Y Acad Sci 2010; 1205: 192-198.

Simmons D. Best Pract Res Clin Endocrinol Metab 2010; 24(4): 625-634.

Palomba S, Falbo A, Russo T, Orio F. Hum Reprod 2010; 25(4): 1005-1013.

Tang T, Lord JM, Norman RJ et al. Cochrane Library 2012; 5: CD003053.

Viollet B, Guigas B, Sanz Garcia N, et al. Clin Sci (Lond) 2012; 122(6): 253-270.

Manzor-al-ajdad O, Samani EN, Abadi A. Int J Fertil and Sterilly 2011; 4(4): 168-171.

Calle de la M, Gallardo T, Diestro MD, et al. Clinical Medicine 2007; 129(8): 292-294.

Rekha S, Palet ML, Pooja G, et al. Intern J Medicine and Medical Sciences 2013; 5(3): 116-123.

McCarty MF. Med Hypoth 2000; 55: 289-293.

Wijeyaratne CN, Nirantharakumar K, Balen AH, et al. Clinical Endocrinol 2004; 60(5): 560-567.

Kilicdag EB, Bagis T, Zeyneloglu HB, et al. Hum Reprod 2005; 20(4): 894-899.

Liu Q, Li S, Quan H, Li J. PLoS One 2014(6): e100379.

Pietrzik K, Bailey L, Shane B. Clin Pharmacokinet 2010; 49(8): 535-548.

Crider KS, Yang TP, Berry RJ, et al. Adv Nutr 2012; 3(1): 21-38.

Forges T, Pellanda H, Divigent C, et al. Gynecol Obstet 2008; 36(9): 936-939.

Dubey P, Gupta N, Dwivedi S, et al. Contracept Obstet Gynecol 2013; 2(2): 165-171.

Maluhsevа LI, Fetisova IN, Fetisov NS, Gordiva AV. Medical Forum 2015; 2(1): 52-56.

The Rotterdam ESHRE/ ASRM- sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteriaand long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 2004; 19(1): 41-47.

Yilmaz M, Biri A, Bukan N, et al. Gynecol Endocrinol 2005; 20(5): 258-263.

Bruno RV, . de Avila MA, Neves FB. Fertil Steril 2007; 88: 510-512.

Khalil IAM. Austin J Reprod Med Infertil 2015; 2(2): 1013-1017.

Most read articles by the same author(s)