The Role of Neutrophilic Leukocytes in the Pathogenesis of Human Type 1 Diabetes (Analytical Review with the Inclusion of Our Own Data)

K.P. Zak

Abstract


Modern literature and the results of our own studies on the role of neutrophils in the body of a healthy person and in a patient with diabetes mellitus type 1 (DM‑1) were analyzed. The article presents the latest data on the content, ultrastructure and functions (phagocytosis, netosis, secretion of bactericidal and immunoregulatory compounds) of blood neutrophils in various stages of DM‑1, starting from the preclinical period. Particular attention is paid to the involvement of neutrophils in various reactions of natural and adaptive immunity. There were discussed the new data on the neutrophil infiltration of the exocrine pancreas and islets of Langerhans, as well as the possibility of direct destructive effect of neutrophils on β-cells, which became the basis for the correction of existing hypotheses about the pathogenesis of DM‑1 in humans, i.e. for approval that not only T-cells of adaptive immunity, but also cellular elements of natural immunity, in particular neutrophils, play an important role in the mechanism of DM‑1 onset.

Keywords


type 1 diabetes mellitus; pathogenesis.

References


Бутенко А.К., Афанасьева В.В., Глуховская И.Ю., Климнюк Г.И., Балицкая О.В., Зак К.П. Ультраструктурная характеристика лейкоцитов крови при лечении рчГ-КСФ (фил­грастимом) химиотерапевтической миелосупрессии у детей с неходжкинскими лимфомами // Эксперим. онкология. — 1997. — ​Т. 19, № 2. — ​С. 147-152.

Бутенко З.А., Глузман Д.Ф., Зак К.П. и др. Цитохимия и электронная микроскопия клеток крови и кроветворных органов / Под ред. В.Г. Пинчука; Ин-т пробл. онкологии, Киев. НИИ эндокринологии и обмена веществ. — ​К.: Наук. думка, 1974. — 247 с.

Дейл М.М. Нейтрофильные лейкоциты // Руководство по иммунофармакологии / Под ред. М.М. Дейла, Дж.К. Формена. — ​М.: Медицина, 1998. — 331 с.

Зак К.П., Малиновская Т.Н., Тронько Н.Д. Иммунитет у детей, больных сахарным диабетом. — ​К.: Книга плюс, 2002. — 111 с.

Зак К.П., Попова В.В. Иммунная интервенция в терапии сахарного диабета (аналитический обзор) // Диабет. Ожирение. Метаболический синдром. — 2015. — № 6 (IV). — ​С. 31-44.

Зак К.П., Тронько Н.Д., Попова В.В., Бутенко А.К. Сахарный диабет. Иммунитет. Цитокины. — ​К.: Книга-плюс. — 2015. — 485 с.

Комиссаренко С.В., Зак К.П. Радиация и иммунитет человека. — ​К.: Наукова думка, 1994. — 111 с.

Окороков А.И., Селиванов В.Н., Немцов В.M. и др. Функциональное состояние лейкоцитов у больных сахарным диабетом // Терапевтический архив. — 1982. — ​Т. 54, № 10. — ​С. 27-30.

Шиффман Ф. Дж. Патофизиология крови. — ​М.: Бином, 2009. — 446 с.

Abrass C.K. Fc-receptor-mediated phagocytosis: abnormalities associated with diabetes mellitus // Clin. Immunol. Immunopathol. — 1991. — ​Vol. 58, № 1. — ​P. 1-17.

Ackerman G.A. The human neutrophilicmyelocyte. A correlated phase and electron microscopic study // Z. Zellforsch. Mikrosk. Anat. — 1971. — ​Vol. 121, № 2. — ​P. 153-170.

Ackerman G.A. The human neutrophilicpromyelocyte. A correlated phase and electron microscopic study // Z. Zellforsch. Mikrosk. Anat. — 1971. — ​Vol. 118, № 4. — ​P. 467-481.

Atkinson M.A., Eisenbarth G.S., Michels A.W. Type 1 diabetes // Lancet. — 2014. — ​Vol. 38, № 9911. — ​P. 69-82.

Atkinson M.A., von Herrath M., Powers A.C., Clare-Salzler M.Current concepts on the pathogenesis of type 1 diabetes — ​considerations for attempts to prevent and reverse the disease // Diabetes Care. — 2015. — ​Vol. 38, № 6. — ​P. 979-988.

Baggiolini M., Dewald B. The neutrophil // Int. Archs Allergy and Appl. Immunology. — 1985. — ​Vol. 76, Suppl. 1. — ​P. 13-20.

Bainton D.F., Ullyot J.L., Farquhar M.G. The developmentof neutrophilicpolymorphonuclear leukocytes in human bone marrow // J. Exp. Med. — 1971. — ​Vol. 134, № 4. — ​P. 907-934.

Battaglia M., Atkinson M.A. The streetlight effect in type 1 diabetes // Diabetes. — 2015. — ​Vol. 64, № 4. — ​P. 1081-1090.

Bessis M. Living blood cells and their ultrastructure. — ​New York; Heidelberg; Berlin: Springer-Verlag, 1973. — 239 p.

Borregaard N. Neutrophils, from marrow to microbes // Immunity. — 2010. — ​Vol. 33, № 5. — ​P. 657-670.

Cieutat A.M., Lobel P., August J.T. et al. Azurophilic granules of human neutrophilic leukocytes are deficient in lysosome-associated membrane proteins but retain the mannose 6-phosphate recognition marker // Blood. — 1998. — ​Vol. 91, № 3. — ​P. 1044-1058.

Combart A.F. The end of line for neutrophils // Blood. — 2015. — ​Vol. 125, № 11. — ​P. 1688-1690.

Diana J., Simoni Y., Furio L. et al. Crosstalk between neutrophils, B‑1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes // Nat. Med. — 2013. — ​Vol. 19, № 1. — ​P. 65-73.

Dziatkowiak H., Kowalska M., Denys A. Phagocytic and bactericidal activity of granulocytes in diabetic children // Diabetes. — 1982. — ​Vol. 31, № 12. — ​P. 1041-1043.

Glowacka E., Banasik M., Lewkowicz P., Tchorzewski H. The effect of LPS on neutrophils from patients with high risk of type 1 diabetes mellitus in relation to IL‑8, IL‑10 and IL‑12 production and apoptosis in vitro // Scand. J. Immunol. — 2002. — ​Vol. 55, № 2. — ​P. 210-217.

Haller M.J., Gitelman S.E., Gottlieb P.A. et al. Anti-thymocyte globulin/G-CSF treatment preserves β cell function in patients with established type 1 diabetes // J. Clin. Invest. — 2015. — ​Vol. 125, № 1. — ​P. 448-455.

Herskowitz I.C., Matsutani A., Permutt M.A. Reversibility of respiratory burst dysfunction in the human diabetic neutrophil is dependent on tight control of the diabetic state // Diabetes. — 1991. — ​Vol. 40, Suppl. 1. — ​P. 475A.

Hisashi N., Yuichi H., Moriyasu T. et al. Фагоцитарная и бактерицидная активность полиморфноядерных лейкоцитов у больных инсулинзависимым сахарным диабетом (ИЗСД). Связь между функцией полиморфноядерных нейтрофилов и контролем гликемии // J. Jap. Diabet. Soc. — 1991. — ​Vol. 34, № 1. — ​P. 7-13.

Kallionpää H., Elo L.L., Laajala E. et al. Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility // Diabetes. — 2014. — ​Vol. 63, № 7. — ​P. 2402-2414.

Kjeldsen L., Bainton D.F., Sengeløv H., Borregaard N. Identification of neutrophil gelatinase-associated lipocalin as a novel matrix protein of specific granules in human neutrophils // Blood. — 1994. — ​Vol. 83, № 3. — ​P. 799-807.

Leslie R.D., Bradford C. Autoimmune diabetes: Caught in a NET // Diabetes. — 2014. — ​Vol. 63, № 12. — ​P. 4018-4020.

http://www.hindawi.com/journals/ije/2015/765364/Lucisano S., Arena A., Stassi G. et al. Role of paricalcitol in modulating the immune response in patients with renal disease role of paricalcitol in modulating the immune response in patients with renal disease // International J. Endocrinology. — 2015. Article ID 765364, 8 pages.

Miller M. Phagocytic cell functions in diabetes mellitus // Immunol. Clin. and Exp. Diabetes. — ​New York; London, 1984. — ​P. 369-383.

Mohanty T., Sjögren J., Kahn F. et al. A novel mechanism for NETosis provides antimicrobial defense at the oral mucosa // Blood. — 2015. — ​Vol. 126, № 18. — ​P. 2128-2137.

Nielson C.P., Hindson D.A. Inhibition of polymorphonuclear leukocyte respiratory burst by elevated glucose concentrations in vitro // Diabetes. — 1989. — ​Vol. 38, № 8. — ​P. 1031-1035.

Pisarczyk-Wiza D., Zozulinska D., Majchrzak A. et al. The influence of postprandial state on the polymorphonuclear neutrophils function in type 1 diabetic patients // Diabetologia. — 2002. — ​Vol. 45, Suppl. 2 (A‑36), 101.

Rodriguez-Calvo T., Ekwall O., Amirian N. et al. Increased immune cell infiltration of the exocrine pancreas: a possible contribution to the pathogenesis of type 1 diabetes // Diabetes. — 2014. — ​Vol. 63, № 11. — ​P. 3880-3890.

Röep B.O. β-cells, autoimmunity, and the innate immune system: un menage a trois // Diabetes. — 2013. — ​Vol. 62. — ​P. 1821-1822.

Roychaudhuri R., Hergrueter A.H., Polverino F. et al. ADAM9 is a novel product of polymorphonuclear neutrophils: regulation of expression and contributions to extracellular matrix protein degradation during acute lung injury // J. Immunol. — 2014. — ​Vol. 193, № 5. — ​P. 2469-2482.

Schilder L., Nurmohamed S.A., ter Wee P.M. et al. The plasma level and biomarker value of neutrophil gelatinase-associated lipocalin in critically ill patients with acute kidney injury are not affected by continuous venovenous hemofiltration and anticoagulation applied // Clinical Care. — 2014, 18 April R 78.

Tanaka Y., Goodman J.R. Electron microscopy of human blood cells. — ​New York; London: Harper at Row. Publ., 1972. — 432 p.

Valle A., Giamporcaro G.M., Scavini M. et al. Reduction of circulating neutrophils precedes and accompanies type 1 diabetes // Diabetes. — 2013. — ​Vol. 62, № 6. — ​P. 2072-2077.

Wang Y., Xiao Y., Zhong L. et al. Increased neutrophil elastase and proteinase 3 and augmented NETosis are closely associated with β-Cell autoimmunity in patients with type 1 diabetes // Diabetes. — 2014. — ​Vol. 63, № 12. — ​P. 4239-4248.

Wicks K., Torbica T., Umehara T. et al. Diabetes inhibits Gr‑1+ myeloid cell maturation via Cebpa deregulation // Diabetes. — 2015. — ​Vol. 64, № 12. — ​P. 4184-4197.

Wierusz-Wysocka B., Wysocki H., Wykretowicz A. et al. Phagocytosis, bactericidal capacity, and superoxide anion (O2–) production by polymorphonuclear neutrophils from patients with diabetes mellitus // Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. — 1985. — ​Vol. 112, № 5. — ​P. 658-668.

Wilson R.M., Reeves W.G. Neutrophil phagocytosis and killing in insulin-dependent diabetes // Clin. Exp. Immunol. — 1985. — ​Vol. 63, № 2. — ​P. 478-483.

Wright D.G. The neutrophil as a secretory organ of host defense. — ​In: Advances in host defense mechanisms: Phogocytic cells / J.I. Gallin, A.S. Fauci (eds.). — ​New York: Raven Press, 1982. — ​Vol. 1. — ​P. 75-110.

Ye Y., Carlsson G., Karlsson-Sjöberg J.M. et al. The antimicrobial propeptidehCAP‑18 plasma levels in neutropenia of various aetiologies: a prospective study // Sci. Rep. — 2015 Jun 29. — 5. — 11685. doi: 10.1038/srep11685.

Zak K.P., Afanasyeva V.V., Yefimov A.S., Tkach S.N. Ultrastructure of neutrophils of non treated patients with newly diagnosed IDDM and effects of human insulin therapy: 15 International Diabetes Federation Congress (November 6-11, 1994). — ​Kobe, Japan. — 07A5PP0362.

Zak K.P., Filatova R.S., Afanasyeva V.V. Cytochemical and ultracytochemical studies of peroxidase activity in rabbit blood granulocytes under hydrocortisone effect // Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. — 1983. — ​Vol. 110, № 4. — ​P. 490-502.




DOI: https://doi.org/10.22141/2224-0721.2.74.2016.70956

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© "Publishing House "Zaslavsky", 1997-2017

 

 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru