Мonocyte Chemoattractant Protein Levels in Patients with Primary Hypothyroidism
Objective of the research — to study the content of monocyte chemoattractant protein‑1 (MCP‑1) in the urine of patients with primary hypothyroidism.
Materials and methods. 141 patients with overt hypothyroidism have been examined. Among them, 71 patients had postoperative hypothyroidism, 70 — hypothyroidism on the background of autoimmune thyroiditis (AIT). Patients were divided: into I A group consisted of 35 patients with hypothyroidism following AIT without obesity; I B group — 35 patients suffering from AIT with hypothyroidism and obesity; II A group — 34 patients with postoperative hypothyroidism without obesity; II B group — patients with postoperative hypothyroidism and obesity.
Results. The surveyed patients had significant increase of MHP‑1 levels in all groups. During correlation analysis, we have established a direct correlation between levels of MHP‑1 and thyroid-stimulating hormone, as well as creatinine levels in the blood and the reverse correlation of medium strength between glomerular filtration rate and concentration of MHP‑1, with the highest severity in the uncompensated hypothyroidism on the background of AIT with obesity.
Conclusions. Identified correlations indicate that the level of MHP‑1 to a certain extent reflects renal function and can be used as a complement to traditional methods of examination of patients.
Basu G, Mohapatra A. Interactions between thyroid disorders and kidney disease. Indian J. Endocrinol. Metab. 2012; 16 (2): 204-213.
Lee EU, Chung CH, Khoury CC. The monocyte chemoattractant protein-1/CCR2 loop, inducible by TGF beta, increases podocyte motility and albumin permeability. Amer. J. Physiol. Renal Physol. 2009; 297 (1): 85-94.
Chiarelli F, Cipollone F, Mohn A. Circulating monocyte chemoattractant protein-1 and early development of nephropathy in type 1 diabetes. Diabetes Care 2002; 25:1829-34.
Carrero JJ, Qureshi AR, Axelsson J. Clinical and biochemical implications of low thyroid hormone levels (total and free forms) in euthyroid patients with chronic kidney disease. Journal of Internal Medicine. 2007; 262 (6): 690-701.
Choi KM, Lee J, Lee KW, Seo JA. Comparison of serum concentrations of C-reactive protein, TNF-alpha, and IL6 between elderly Korean women with normal and impaired glucose tolerance. Diabetes Res.Clin.Pract. 2004; 64: 99-106.
Petkov S, Navarro JAM, Herrero EM, Sanchez MJG. Decrease in renal function associated with hypothyroidism. Nephrologia. 2010; 30 (3): 378-380.
Eddy AA. Progression in chronic kidney disease. Adv. Chronic Kidney Dis. 2005; 12: 353-365.
Giunti S, Barutta F, Perin PC, Gruden G. Targeting the MCP-1/CCR2 System in diabetic kidney disease. Curr. Vasc. Pharmacol. 2010; 8(6): 849-860.
Den Hollander J.G., Wulkan R.W., Mantel M.J., Berghout A. Correlation between severity of thyroid dysfunction and renal function. Clin Endocrinol. 2005; 62: 423-427.
Vargas F, Moreno JM, Rodriguez-Gomez I. Vascular and renal function in experimental thyroid disorders. Eur. J. Endocrinol. 2006; 154: 197-212.
Vernon MA, Mylonas KJ, Hughes J. Macrophages and renal fibrosis. Semin. Nephrol. 2010; 30(3): 302-317.
Meuwese CL, Dekker F.W, Lindholm B. Baseline levels and trimestral variation of triiodothyronine and thyroxine and their association with Mortality in maintenance hemodialysis patients. Clin. J. Am. Soc. Nephrol. 2012; 7: 131-38.
Razvi S. The Influence of Age on the relationship between subclinical hypothyroidism and ischemic heart disease: a metaanalisis. J. Clin. Endocrinol. Metabol. 2008; 93(8): 59-67.
Tesch GH. MCP-1/CCL2: a new diagnostic marker and therapeutic target for progressive renal injury in diabetic nephropathy. Am. J. Physiol. Renal Physiol. 2008; 294: 697-701.
Malyszko JS, Pawlak K, Mysliwiec M. Thyroid function, endothelium, and inflammation in hemodialyzed patients: possible relations? J. Ren. Nutr. 2007; 17 (1): 30-37.
Williams TM, Little MH, Ricardo SD. Macrophages in renal development, injury, and repair. Semin. Nephrol. 2010, 30(3): 255-267.
Copyright (c) 2021 O.M. Didushko
This work is licensed under a Creative Commons Attribution 4.0 International License.
© "Publishing House "Zaslavsky", 1997-2020