Association of Certain Endothelial Function Indicators with T894G Polymorphism of Endothelial Nitric Oxide Synthase Gene in Patients with Hypothyroidism and Concomitant Chronic Cholecystitis
The association of the T894G endothelial nitric oxide synthase (eNOS) gene polymorphism with certain indicators of endothelial function in patients with hypothyroidism and concomitant chronic non-calculous cholecystitis was investigated. Significant increase by 33.1 % (P = 0.01) of desquamated endothelial cells number in the blood was found in patients with T-allele compared with that of in GG-genotype carriers. Also, the concentration of total nitric oxide stable metabolites was 10.4 % (P = 0.04) higher and the level of nitrate anions in the blood was 10.8 % (P = 0.02) higher than in comparison group. Among patients with hypothyroidism and concomitant chronic cholecystitis, the content of vascular endothelial growth factor was 27.7 % (P = 0.03) higher in T-allele carriers as compared with patients with GG-genotype.
Full Text:PDF (Українська)
Abdalla X. The distribution of genotypes and alleles of genes Setter and eNOS in patients with myocardial infarction. Ukrayin. terapevt. zhurn., 2011; 2: 56–61. Russian
Petryshhev NN, Berkovych OA, Vlasov TD. Diagnostic value of determination of desquamated endothelial cells in the blood. Klynycheskaya laboratornaya dyagnostyka, 2001; 1: 50–52. Russian
Moyseev VS, Korovyna EP, Kobalava ZhD. Clinical and genetic aspects of the hypotensive response and reverse development of left ventricular hypertrophy in hypertensive patients. Ter. arxyv, 2002; 10: 30–37. Russian
Kovalenko OYe, Lytvyn OV. Peculiarities of hypertensive encephalopathy in patients with hypothyroidism. Ukrayinskyy medychnyy al'manakh, 2011; 14: 103. Ukrainian
Pavlovskyy MP, Syroyid OM, Kolomiytsev VI. Features of patients with cholelithiasis and thyrotoxicosis. Klinichna endokrynolohiya ta endokrynna khirurhiya, 2012; 2(39): 77–78.Ukrainian
Pankiv VI. Hypothyroidism syndrome. Mizhnarodnyy endokrynolohichnyy zhurnal, 2012; 5: 83 – 87.Ukrainian
Babak OYa, Fadyeyenko HD, Frolov VM. Indicators syndrome endogenous «metabolic» intoxication in patients with nonalcoholic steatohepatitis, combined with chronic non-calculous cholecystitis, the application of combination therapy. Suchasna hastroenterolohiya, 2012; 1: 19-24.Ukrainian
Balaczkyj AV, Andreenko EYu, Samoxodskaya LM. Polymorphism of genes of endothelial NO-synthase and connexin-37 as a risk factor for myocardial infarction in patients without a history of coronary.Ter. arxyv, 2013; 9: 18–22. Russian
Syroyid OM. Endocrine factors of gallstone disease pathogenesis. Naukovyy visnyk Uzhhorods'koho universytetu. Ser.: Medytsyna, 2011; 2: 233–236. Ukrainian
Spyrydonova MG, Tryfonova EA, Fadyushyna SV. Molecular genetic analysis of polymorphic markers of genes responsible for the operation of the factors endothelial system in connection with the occurrence of complicated pregnancy. Medycynskaya genetyka, 2007; 7: 38–42. Russian
Nozaki Y, Fujita K, Wada K. Deficiency of eNOS exacerbates early-stage NAFLD pathogenesis by changing the fat distribution. BMC Gastroenterol, 2015; 15(1): 177.
Selmi C, Zuin M, Biondi ML, Invernizzi P, Battezzati PM, Bernini M, Meda F, Gershwin ME, Podda M. Genetic variants of endothelial nitric oxide synthase in patients with primary biliary cirrhosis: association with disease severity. Journal of Gastroenterology and Hepatology, 2003; 18: 1150–1155.
Harrison DG. Cellular and molecular mechanisms of endothelial cell dysfunction. J. Clin. Invest,1997;100(9):2153–2157.
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution 4.0 International License.
© "Publishing House "Zaslavsky", 1997-2017