Prevalence of various forms of diabetes insipidus and its complications in the Republic of Uzbekistan

Main Article Content

Yu.M. Urmanova
D.I. Khamraeva

Abstract

Background. Central diabetes insipidus is characte­rized by the inability of the kidneys to reabsorb water and concentrate urine, which is due to the defect in the synthesis or secretion of vasopressin and is manifested by severe thirst and excretion of large amounts of diluted urine. The purpose of the study is to assess the prevalence of various forms of diabetes insipidus and its complications, the quality of diagnosis and treatment according to the data of regional endocrinological dispensaries of the Republic of Uzbekistan. Materials and methods. The study used data from the register of patients with diabetes insipidus registered in regional endocrinological centers in all regions of the Republic of Uzbekistan and the Republic of Karakalpakstan in 2018, as well as our own observations. It was found that by the end of 2018, 1,237 children and adolescents with diabetes insipidus were registered in the Republic of Uzbekistan and the Republic of Karakalpakstan. Of these, data of 397 patients with diabetes insipidus were analyzed. Their average age was 5.6 ± 2 years. Results. The idiopathic form of diabetes insipidus was observed predominantly — in 214 individuals (55.8 %), the second most common form was central diabetes insipidus — 129 patients (40.9 %), while the renal and hereditary forms of the disease were less common — 26 (3.3 %) and 3 (0.2 %), respectively. The majority of patients (48.9 %) did not associate the onset of the disease with any factor. However, in 20.4 % of individuals, diabetes insipidus developed after a skull injury. In 4.8 % of patients, the cause of the disease was tumors of the hypothalamic-pituitary region, and in 14.5 % — neuroviral infection. Hereditary predisposition was observed in 0.4 % of patients. Conclusions. In the regions of the Republic of Uzbekistan and the Republic of Karakalpakstan, two forms of diabetes insipidus were most common: idiopathic — 214 (55.8 %) and central — 129 cases (40.9 %). Most of the patients — 85 children (22.9%) — were aged 0 to 9 years. The average age of ill children and adolescents was 7.6 years. The disease was more often detected in males (51.1 %).

Article Details

How to Cite
Urmanova, Y., and D. Khamraeva. “Prevalence of Various Forms of Diabetes Insipidus and Its Complications in the Republic of Uzbekistan”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), vol. 16, no. 8, Apr. 2021, pp. 692-7, doi:10.22141/2224-0721.16.8.2020.222891.
Section
Original Researches

References

Garrahy A, Sherlock M, Thompson CJ. Management of endocrine disease: Neuroendocrine surveillance and management of neurosurgical patients. Eur J Endocrinol. 2017 May;176(5):R217-R233. doi:10.1530/EJE-16-0962.

Dedov II, Mel’nichenko GA, Pigarova EA, et al. Federal clinical guidelines on diagnosis and treatment of diabetes insipidus in adults. Obesity and metabolism. 2018;15(2):56-71. doi:10.14341/OMET9670. (in Russian).

Nayak P, Montaser AS, Hu J, Prevedello DM, Kirschner LS, Ghalib L. Predictors of Postoperative Diabetes Insipidus Following Endoscopic Resection of Pituitary Adenomas. J Endocr Soc. 2018 Jul 27;2(9):1010-1019. doi:10.1210/js.2018-00121.

Milano S, Carmosino M, Gerbino A, Svelto M, Procino G. Hereditary Nephrogenic Diabetes Insipidus: Pathophysiology and Possible Treatment. An Update. Int J Mol Sci. 2017 Nov 10;18(11):2385. doi:10.3390/ijms18112385.

Robertson GL. Diabetes insipidus: Differential diagnosis and management. Best Pract Res Clin Endocrinol Metab. 2016 Mar;30(2):205-218. doi:10.1016/j.beem.2016.02.007.

Garrahy A, Sherlock M, Thompson CJ. Management of endocrine disease: Neuroendocrine surveillance and management of neurosurgical patients. Eur J Endocrinol. 2017 May;176(5):R217-R233. doi:10.1530/EJE-16-0962.

Pigarova EA, Dzeranova LK. Diagnosis and treatment of central diabetes insipidus. Obesity and metabolism. 2014;11(4):48. doi:10.14341/omet2014448-55. (in Russian).

Chang LS, Yialamas MA. Checkpoint Inhibitor-Associated Hypophysitis. J Gen Intern Med. 2018 Jan;33(1):125-127. doi:10.1007/s11606-017-4135-6.

Ghirardello S, Malattia C, Scagnelli P, Maghnie M. Current perspective on the pathogenesis of central diabetes insipidus. J Pediatr Endocrinol Metab. 2005 Jul;18(7):631-645. doi:10.1515/jpem.2005.18.7.631.

Adams JR, Blevins LS Jr, Allen GS, Verity DK, Devin JK. Disorders of water metabolism following transsphenoidal pituitary surgery: a single institution's experience. Pituitary. 2006;9(2):93-99. doi:10.1007/s11102-006-9276-2.

Arai SR, Butzlaff A, Stotts NA, Puntillo KA. Quench the thirst: lessons from clinical thirst trials. Biol Res Nurs. 2014 Oct;16(4):456-466. doi:10.1177/1099800413505900.

Milano S, Carmosino M, Gerbino A, Svelto M, Procino G. Hereditary Nephrogenic Diabetes Insipidus: Pathophysiology and Possible Treatment. An Update. Int J Mol Sci. 2017 Nov 10;18(11):2385. doi:10.3390/ijms18112385.

Fleseriu M, Hashim IA, Karavitaki N, et al. Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016 Nov;101(11):3888-3921. doi:10.1210/jc.2016-2118.

Bhatia MS, Goyal A, Saha R, Doval N. Psychogenic Polydipsia - Management Challenges. Shanghai Arch Psychiatry. 2017 Jun 25;29(3):180-183. doi:10.11919/j.issn.1002-0829.216106.

Chanson P, Salenave S. Treatment of neurogenic diabetes insipidus. Ann Endocrinol (Paris). 2011 Dec;72(6):496-499. doi:10.1016/j.ando.2011.09.001.

Arima H, Oiso Y, Juul KV, Nørgaard JP. Efficacy and safety of desmopressin orally disintegrating tablet in patients with central diabetes insipidus: results of a multicenter open-label dose-titration study. Endocr J. 2013;60(9):1085-1094. doi:10.1507/endocrj.ej13-0165.

Robertson GL. Diabetes insipidus: Differential diagnosis and management. Best Pract Res Clin Endocrinol Metab. 2016 Mar;30(2):205-218. doi:10.1016/j.beem.2016.02.007.

Most read articles by the same author(s)

1 2 3 4 > >>