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Background. According to the definition, internally displaced person is someone who is forced to flee his or her home but who remains within his or her country’s borders. Pregnancy is a state of increased vulnerability for the development of anxiety and depression, which are the most common mental disorders during pregnancy and after childbirth. About 54 % of women experience anxiety throughout the antenatal period, depressive disorders are manifested in 34 % of patients. According to some authors, sleep disturbances, which are reported by 11.5 to 85 % of pregnant women, can affect the severity of antenatal and postnatal depressive and anxiety symptoms, as well as obstetric outcomes. The purpose of this research was to evaluate the effectiveness of comprehensive treatment in pregnant women with threatened miscarriage, who are living in the Luhansk region and having the status of an internally displaced person, to improve treatment and prophylactic measures and prevent obstetric and perinatal complications. Materials and methods. The study included 22 internally displaced women in first and second trimesters of pregnancy, who were admitted for threatened miscarriage to the hospitals located in the Luhansk region. Patients were randomly divided into subgroups (1a and 1b). Women of subgroup 1b were additionally treated with L-arginine, magnesium lactate dihydrate and pyridoxine hydrochloride for two weeks, as well as a vitamin-mineral complex. Clinical obstetric and psychometric examination was carried out before and after the treatment. Spielberger’s State-Trait Anxiety Inventory was used to assess the level of anxiety, Beck Depression Inventory — to evaluate the level of depression, the questionnaire by A.M. Wein — to assess the autonomic disorders, the sleep quality questionnaire of the сenter for somnology — to evaluate the quality of sleep. The concentrations of progesterone and magnesium were determined. Results. After treatment, a statistically significant decrease in state anxiety, depressive manifestations and autonomic disorders was observed. The sleep parameters in patients of both groups significantly changed towards improvement. The indicator of trait anxiety in group 1a did not change significantly after the treatment. The concentration of progesterone increased in both groups, and magnesium level increased only in group 1b. Conclusions. Treatment with L-arginine, magnesium lactate dihydrate, pyridoxine hydrochloride, and a vitamin-mineral complex has been shown to be highly effective in reducing the severity and frequency of psychoemotional disorders in internally displaced women with threatened miscarriage, achieving emotional balance, relieving anxiety, fears associated with pregnancy and childbirth. A decrease in the indicators of state anxiety, depressive disorders, autonomic manifestations, and an improvement in sleep quality indicators can serve as criteria for the effectiveness of the treatment.
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