Vitamin D deficiency and autoimmune thyroid disease: relationship and correction (literature review and clinical cases)
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Abstract
Numerous studies by various authors indicate an association between vitamin D and autoimmune thyroid diseases. Most authors point to a correlation between lower vitamin D levels and an increased risk of developing the disease and/or higher antibody titers. After the onset of autoimmune thyroid disease, the existing vitamin D deficiency creates a vicious circle, exacerbating the deficiency. In real clinical practice, it is important to correct vitamin D deficiency/insufficiency in persons with autoimmune thyroid diseases. The approach is to achieve a level of 25(OH)D within the reference ranges proposed by international guidelines. Vitamin D deficiency is an integral part of the pathogenesis of autoimmune thyroid diseases. Because vitamin D administration reduces antithyroid antibody titers in patients with autoimmune thyroid diseases, vitamin D supplements are recommended for the treatment of these diseases, especially in vitamin D deficiency. Both in Graves’ disease and autoimmune thyroiditis with subclinical hypothyroidism, the initial dose of cholecalciferol is 4,000 IU per day for three months, followed by control of the content of 25(OH)D in the serum. When the level of vitamin D reaches 30–50 ng/ml, it is recommended to continue taking cholecalciferol in a daily dose of 2,000 IU for three months. It is desirable to conduct such courses at least twice a year. As the positive effect of the optimal level of 25(OH)D in the serum of both children and adults has been proven to date, it is advisable to maintain it for a healthy population in the range of 30–50 ng/ml in accordance with the guidelines for Central European countries. There are two cases from real clinical practice, in which a positive effect was achieved after additional administration of cholecalciferol to patients with autoimmune thyroid diseases.
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How to Cite
Pankiv, V. “Vitamin D Deficiency and Autoimmune Thyroid Disease: Relationship and Correction (literature Review and Clinical Cases)”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), vol. 16, no. 7, Mar. 2021, pp. 556-63, doi:10.22141/2224-0721.16.7.2020.219010.
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Literature Review
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