Prognostic significance of risk factors for thyrotoxicosis development in radioiodine therapy

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N.B. Ubaydullaeva
G.I. Allayarova
F.F. Almuradov


Background. Graves’ disease (GD) is a systemic autoimmune disease that develops as a result of the production of antibodies to the thyroid-stimulating hormone receptor, which is clinically manifested by diffuse structural changes in the thyroid gland with the development of thyrotoxicosis syndrome, and also combined with extrathyroid manifestations. The purpose of the study was to identify Graves’ disease recurrence risk factors in women received radioiodine therapy. Materials and methods. 93 women of reproductive age who received radioiodine therapy (RIT) were under obsewrvation. We analyzed the results of the questionnaire and assessed the thyrotoxicosis recurrence risk factors with performed retrospective and prospective analysis of clinical and medical history indicators. Patient’s average age was 36.9 ± 7.1 years. The control group included 35 healthy women aged 33.5 ± 7.6 years. Thyroid stimulating hormone (TSH), free triiodothyonine (fT3) and free thyroxine (fT4) and thyroperoxidase antibodies (TPOAb) levels determined by the immunochemiluminescent method. Results. In order to evaluate the quality of a prognostic model of the thyrotoxicosis recurrence we calculated all risk factors parameters of the AUC. The most significant risk factors for the development of thyrotoxicosis recurrence after RTI with a high relative risk and etiological fraction were age over 30 years (RR = 7.59; EF = 8.82 %), thyroid volume ≥ 30 cm3 (RR = 6.84; EF = 85.38 %), treatment duration ≥ 2 years (RR = 6.37; EF = 84.30 %), patient compliance (RR = 6.19; EF = 83.84 %), RIT multiplicity (RR = 5.74; EF = 82.58 %) and a dose of RIT 300 MBq (RR = 5.41; EF = 81.52 %). Conclusions. It was revealed that the age is older than 30 years (AUC — 0.88), thyroid volume ≥ 30 cm3 (AUC — 0.86), treatment duration ≥ 2 years (AUC – 0.86), patient compliance (AUC — 0.85), RIT multiplicity (AUC — 0.85) and the dose of RIT (AUC — 0.82) have excellent predictive power.

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How to Cite
Ubaydullaeva, N., G. Allayarova, and F. Almuradov. “Prognostic Significance of Risk Factors for Thyrotoxicosis Development in radioiodine Therapy”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), vol. 16, no. 6, Oct. 2020, pp. 502-6, doi:10.22141/2224-0721.16.6.2020.215390.
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