Vitamin D level and indicators of carbohydrate metabolism in women with polycystic ovary syndrome

Main Article Content

T.L. Arkhypkina
V.A. Bondarenko
O.A. Goncharova
L.P. Lyubimovа

Abstract

Background. Polycystic ovary syndrome (PCOS) remains an urgent problem of gynecological endocrinology, and its frequency is approximately 11–17 % among women of reproductive age and reaches 75 % in the structure of endocrine infertility. There is evidence that vitamin D impacts carbohydrate metabolism, and its insufficiency or deficiency increases the risk of impaired glucose tolerance, insulin resistance and type 2 diabetes mellitus (DM). The purpose of this study is to determine the relationship between vitamin D levels and indicators of carbohydrate metabolism in wo­men with polycystic ovary syndrome. Materials and methods. Sixty women aged from 19 to 26 years were examined: 30 women with a diagnosis of the classical phenotype of PCOS; 30 healthy women with normal menstrual and reproductive function. We stu­died the content of vitamin D, sex steroid-binding globulin (SSBG), immunoreactive insulin (IRI), HOMA-IR index, body mass index (BMI), waist-hip ratio. Depending on the concentration of vitamin D, women were divided into subgroups: the first enrolled 22 patients with PCOS with vitamin D ≤ 30 ng/ml (average level 12.9 ± 0.2 ng/ml); the second included 8 patients with a level of vitamin D ≥ 30 ng/ml (31.4 ± 0.3 ng/ml); the third group consisted of 12 healthy women with vitamin D ≤ 30 ng/ml (24.2 ± 0.3 ng/ml); fourth group consisted of 18 healthy women with a level of vitamin D ≥ 30 ng/ml (35.6 ± 0.3 ng/ml). Results. It was found that in the basic group of PCOS patients, the average level of vitamin D (21.4 ± 0.4 ng/ml) was significantly lower (P < 0.001) compared to the group of healthy women (29.6 ± 0.3 ng/ml). In patients with PCOS, low concentrations of vitamin D were accompanied by hig­her levels of glucose (P < 0.001), IRI (P < 0.001), HOMA-IR index (P < 0.001), and a decreased level of SSBG (P < 0.001). A negative association of vitamin D with BMI (r = –0.399; P < 0.05), waist-hip ratio (r = –0.612; P < 0.001), IRI concentration (r = –0.502; P < 0.001), HOMA-IR index (r = –0.571; P < 0.001), the level of SSBG (r = –0.694; P < 0.001) was established. Conclusions. The results of the study demonstrate the role of abdominal obesity in the formation of vitamin D deficiency, which intensifies the carbohydrate metabolism disorders, increases hyperinsulinemia, insulin resistance and reduces the production of sex steroid-binding globulin in women with PCOS.

Article Details

How to Cite
Arkhypkina, T., V. Bondarenko, O. Goncharova, and Lyubimovа L. “Vitamin D Level and Indicators of Carbohydrate Metabolism in Women With Polycystic Ovary Syndrome”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), vol. 16, no. 5, Aug. 2020, pp. 381-6, doi:10.22141/2224-0721.16.5.2020.212740.
Section
Original Researches

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