Main Article Content
Background. Metabolic syndrome (MS) affects about a quarter of the world population and is accompanied by abdominal obesity and insulin resistance, which are the factors of dyslipidemia, hypertension and hyperglycemia. Nonthyroidal illness syndrome affects about 75 % of hospitalized patients and is accompanied by peripheral hypothyroidism due to inhibition of peripheral conversion of thyroid hormones. Due to the fact that about 80 % of thyroid hormones are produced in peripheral organs, and they regulate almost all processes in the body, the pathological changes that accompany nonthyroidal illness syndrome can be regarded significant. However, the effectiveness of vitamin complexes in combination with selenium in treatment of MS remains unknown. The purpose of the research was to study the effectiveness of Oxylyc in the comprehensive treatment of disorders of carbohydrate, lipid metabolism, endothelial function, antioxidant system, thyroid homeostasis in patients with metabolic syndrome. Materials and methods. Sixty-five patients were enrolled to the study. All patients were previously diagnosed with metabolic syndrome. To assess the effectiveness of treatment, patients were randomized into two groups. Patients of the first group (30 people) received Oxylyc — one capsule for 1 month on the background of basic treatment. Representatives of the second group (35 people) received basic treatment. Results. Additional administration of Oxylyc in treatment of patients with MS for 1 month leads to a significant improvement in the sensitivity of receptors to insulin, which is reflected in a decrease in HOMA-IR, indicators of the functional state of the endothelium (decreased production of vascular endothelial growth factor, and desquamation of endothelium), lipid metabolism (decrease in cholesterol, increase in high density lipoproteins and decrease in atherogenic coefficient, decrease in the titer of the free thyroxine (fТ4), increase in the free triiodothyronine (fТ3) and the ratio of fT3/fT4, which indicates an improvement of the peripheral conversion of thyroid hormones). Conclusions. Oxylyc can be recommended in comprehensive treatment of metabolic syndrome.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our edition uses the copyright terms of Creative Commons for open access journals.
Authors, who are published in this journal, agree with the following terms:
- The authors retain rights for authorship of their article and grant to the edition the right of first publication of the article on a Creative Commons Attribution 4.0 International License, which allows others to freely distribute the published article, with the obligatory reference to the authors of original works and original publication in this journal.
- Directing the article for the publication to the editorial board (publisher), the author agrees with transmitting of rights for the protection and using the article, including parts of the article, which are protected by the copyrights, such as the author’s photo, pictures, charts, tables, etc., including the reproduction in the media and the Internet; for distributing; for the translation of the manuscript in all languages; for export and import of the publications copies of the writers’ article to spread, bringing to the general information.
- The rights mentioned above authors transfer to the edition (publisher) for the unlimited period of validity and on the territory of all countries of the world.
- The authors guarantee that they have exclusive rights for using of the article, which they have sent to the edition (publisher). The edition (the publisher) is not responsible for the violation of given guarantees by the authors to the third parties.
- The authors have the right to conclude separate supplement agreements that relate to non-exclusive distribution of their article in the form in which it had been published in the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
- The policy of the journal permits and encourages the publication of the article in the Internet (in institutional repository or on a personal website) by the authors, because it contributes to productive scientific discussion and a positive effect on efficiency and dynamics of the citation of the article.
De Oliveira CM, Pavani J, Krieger JE, de Oliveira Alvim R, Mourão-Junior CA, da Costa Pereira A. Body adiposity index in assessing the risk of type 2 diabetes mellitus development: the Baependi Heart Study. Diabetol Metab Syndr. 2019;11:76. doi:10.1186/s13098-019-0467-1.
Loebig M, Klement J, Schmoller A, et al. Evidence for a relationship between VEGF and BMI independent of insulin sensitivity by glucose clamp procedure in a homogenous group healthy young men. PLoS One. 2010;5(9):e12610. doi:10.1371/journal.pone.0012610.
Schiapaccassa A, Maranhão PA, de Souza MDGC, et al. 30-days effects of vildagliptin on vascular function, plasma viscosity, inflammation, oxidative stress, and intestinal peptides on drug-naïve women with diabetes and obesity: a randomized head-to-head metformin-controlled study. Diabetol Metab Syndr. 2019;11:70. doi:10.1186/s13098-019-0466-2.
Wang B, Liu S, Li L, et al. Non-thyroidal illness syndrome in patients with cardiovascular diseases: A systematic review and meta-analysis. Int J Cardiol. 2017;226:1–10. doi:10.1016/j.ijcard.2016.10.039.
El-Ella SSA, El-Mekkawy MS, El-Dihemey MA. Prevalence and prognostic value of non-thyroidal illness syndrome among critically ill children. An Pediatr (Barc). 2019;90(4):237–243. doi:10.1016/j.anpedi.2018.01.021. (in Spanish).
Himoto T, Yoneyama H, Kurokohchi K, et al. Selenium deficiency is associated with insulin resistance in patients with hepatitis C virus-related chronic liver disease. Nutr Res. 2011;31(11):829–835. doi:10.1016/j.nutres.2011.09.021.
Smith AD, Cheung L, Beshah E, Shea-Donohue T, Urban JF Jr. Selenium status alters the immune response and expulsion of adult Heligmosomoides bakeri worms in mice. Infect Immun. 2013;81(7):2546–2553. doi:10.1128/IAI.01047-12.
Zhang Q, Qian ZY, Zhou PH, et al. Effects of oral selenium and magnesium co-supplementation on lipid metabolism, antioxidative status, histopathological lesions, and related gene expression in rats fed a high-fat diet. Lipids Health Dis. 2018;17(1):165. doi:10.1186/s12944-018-0815-4.
Farhangi MA, Keshavarz SA, Eshraghian M, Ostadrahimi A, Saboor-Yaraghi AA. The effect of vitamin A supplementation on thyroid function in premenopausal women. J Am Coll Nutr. 2012;31(4):268–274. doi:10.1080/07315724.2012.10720431.