DOI: https://doi.org/10.22141/2224-0721.15.7.2019.186062

Transketolase activators as a novel therapy: their significance in the pathogenesis and treatment of diabetic microvascular complications

K. Singh, T. Yuzvenko, D. Kogut

Abstract


The review article presents an analysis of the literature on the effect of thiamine and its derivatives on the metabolism in cells and its role in the pathogenesis of complications of diabetes mellitus. The features of the conversion of an inactive form that enters the human body with food and drugs into the active form of thiamine are considered. The metabolic pathways of thiamine and its derivatives are also clarified. The article describes the features of allithiamine and the practical importance of its metabolism in cells for the treatment of complications of diabetes mellitus, in particular, diabetic polyneuropathy. The data in this article will help clinicians understand the relevance and necessity of using drugs containing thiamine in their practice.

Keywords


diabetes mellitus; microvascular complications; transketolase; diabetic polyneuropathy; thiamine; allithiamines; review

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