New opportunities for the use of alpha-lipoic acid: the role of enantiomers

Main Article Content

T.Yu. Yuzvenko
S.A. Tarasenko
O.V. Marchenko


The literature review considers the use of alpha-li­poic acid (ALA) in clinical practice. The positive effects of ALA as an antioxidant have been demonstrated for a wide range of diseases: diabetic neuropathy, atherosclerosis, hepatitis, cerebrovascular disorder, etc. The new data on the application of the R(+) enantiomer ALA has proved positive biological effects of ALA using. The only R(+) enantiomer ALA realizes all ALA positive features. The R(+) enantiomers of alpha-lipoic acid have the highest peak of plasma concentrations and AUC compared with racemic mixtures. It was showed that 300 mg of R(+) enantiomer of ALA is bioequivalent to 600 mg of racemic ALA.

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How to Cite
Yuzvenko, T., S. Tarasenko, and O. Marchenko. “New Opportunities for the Use of Alpha-Lipoic Acid: The Role of Enantiomers”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), vol. 15, no. 6, Dec. 2019, pp. 507-14, doi:10.22141/2224-0721.15.6.2019.185414.
Literature Review


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