Possibilities of vildagliptin in optimal control of type 2 diabetes mellitus

Main Article Content

V.I. Pankiv

Abstract

Incretin hormones are important for the normal functioning of pancreatic islet cells and glucose homeostasis. In type 2 diabetes mellitus, there is a violation of the sensiti­vity of pancreatic α- and β-cells, which leads to progressive insufficient insulin secretion, insulin resistance due to excessive production of glucagon during periods of postprandial hyperglycemia. In addition, type 2 diabetes mellitus is associated with an increase in lipotoxicity directly related to insulin resistance. The literature review provides data on the safety and efficacy of vildagliptin in patients with type 2 diabetes mellitus, as well as on the pancreatic effects of incretin-targeted therapy. It is clinically confirmed that vildagliptin effectively reduces the level of glycated hemoglobin, has a minimal risk of hypoglycemia and is able to maintain a normal body weight. In addition, vildagliptin inhibits postprandial triglyceride production and decreases fas­ting lipolysis, possibly affecting the inhibition of lipid absorption and triglyceride stores in non-adipose tissue cells.

Article Details

How to Cite
Pankiv, V. “Possibilities of Vildagliptin in Optimal Control of Type 2 Diabetes Mellitus”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), vol. 15, no. 6, Dec. 2019, pp. 482-7, doi:10.22141/2224-0721.15.6.2019.185411.
Section
Literature Review

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