DOI: https://doi.org/10.22141/2224-0721.15.5.2019.180045

Constitutional delay of growth and puberty in boys: review

A.B. Grossman, S.I. Ismailov, M.G. Kulmirzayeva, Y.M. Urmanova, K.N. Gilazitdinov

Abstract


The review focuses on the diagnosis, clinical and general therapeutic approach to constitutional growth and delayed puberty and hypogonadotrophic hypogonadism in men, which are difficult to distinguish. Clinical history and physical examination should be carefully performed. Delayed puberty is due to constitutional growth and delayed sexual development in the vast majority of children. They should be distinguished from a small proportion of boys with hypogonadism — a pathological condition. Several laboratory tests can predict the onset of puberty and progression. However, the emergence of highly sensitive immunoassay and radiometric immunoassay systems for luteinizing hormone, follicle stimulating hormone and testosterone did not completely solve the problem, since their va­lues may overlap between normal and pathological conditions.

Keywords


constitutional delay of growth and puberty; boys; review

References


Heinrichs C. Normal puberty and delayed puberty. Rev Med Brux. 2011 Sep;32(4):256-62.

Zhu J, Chan YM. Fertility Issues for Patients with Hypogonadotropic Causes of Delayed Puberty. Endocrinol Metab Clin North Am. 2015 Dec;44(4):821-34. doi: 10.1016/j.ecl.2015.07.011.

Klein DA, Emerick JE, Sylvester JE, Vogt KS. Disorders of Puberty: An Approach to Diagnosis and Management. Am Fam Physician. 2017 Nov 1;96(9):590-599.

Harrington J, Palmert MR. Clinical review: Distinguishing constitutional delay of growth and puberty from isolated hypogonadotropic hypogonadism: critical appraisal of available diagnostic tests. J Clin Endocrinol Metab. 2012 Sep;97(9):3056-67. doi: 10.1210/jc.2012-1598.

Varimo T, Miettinen PJ, Känsäkoski J, Raivio T4,3, Hero M. Congenital hypogonadotropic hypogonadism, functional hypogonadotropism or constitutional delay of growth and puberty? An analysis of a large patient series from a single tertiary center. Hum Reprod. 2017 Jan;32(1):147-153. DOI: 10.1093/humrep/dew294.

Khizhnyak OO, Mikityuk MR, Barabash NE, Nikolaev RS, Manskaya EH. Screening of hormone-producing pituitary adenomas (Review of literature and own data). Problems of Endocrine Pathology. 2018;4:91-102. doi: 10.21856/j-PEP.2018.4.10.

Rohani F, Alai MR, Moradi S, Amirkashani D. Evaluation of near final height in boys with constitutional delay in growth and puberty. Endocr Connect. 2018 Mar;7(3):456-459. doi: 10.1530/EC-18-0043. 

Colindres JV, Lee YK, Gonzalez MS, Shepherd P. Meeting Report: 2016 Annual Meeting of the Endocrine Society Boston, MA (April 1-4, 2016) Selected Highlights. Pediatr Endocrinol Rev. 2016 Sep;14(1):73-86. doi: 10.17458/PER.2016.CLGS.MR.2016ENDO.

Hussein A, Farghaly H, Askar E, et al. Etiological factors of short stature in children and adolescents: experience at a tertiary care hospital in Egypt. Ther Adv Endocrinol Metab. 2017 May;8(5):75-80. doi: 10.1177/2042018817707464.

Rohayem J, Nieschlag E, Kliesch S, Zitzmann M. Inhibin B, AMH, but not INSL3, IGF1 or DHEAS support differentiation between constitutional delay of growth and puberty and hypogonadotropic hypogonadism. Andrology. 2015 Sep;3(5):882-7. doi: 10.1111/andr.12088.

McGrath N, O’Grady MJ. Aromatase inhibitors for short stature in male children and adolescents. Cochrane Database Syst Rev. 2015 Oct 8;(10):CD010888. doi: 10.1002/14651858.CD010888.pub2.

Kang BH, Kim SY, Park MS, Yoon KL, Shim KS. Estrogen receptor α polymorphism in boys with constitutional delay of growth and puberty. Ann Pediatr Endocrinol Metab. 2013 Jun;18(2):71-5. doi: 10.6065/apem.2013.18.2.71.

Joustra SD, Wehkalampi K, Oostdijk W, et al. IGSF1 variants in boys with familial delayed puberty. Eur J Pediatr. 2015 May;174(5):687-92. doi: 10.1007/s00431-014-2445-9.

Doneray H, Orbak Z. Association between anthropometric hormonal measurements and bone mineral density in puberty and constitutional delay of growth and puberty. West Indian Med J. 2010;59(2):125-30.

Gayretli AZG, Bideci A, Emeksiz HC. Assessment of bone turnover markers and bone mineral density in normal short boys. J Pediatr Endocrinol Metab. 2015;28(11-12):1321-6. doi: 10.1515/jpem-2014-0099.

Wei C, Davis N, Honour J, Crowne E. The investigation of children and adolescents with abnormalities of pubertal timing. Ann Clin Biochem. 2017;54(1):20-32. doi: 10.1177/0004563216668378.

Xie C, Zhao Y, Gao L, Chen J, Cai D, Zhang Y. Elevated phthalates’ exposure in children with constitutional delay of growth and puberty. Mol Cell Endocrinol. 2015;407:67-73. doi: 10.1016//j.mce.2015.03.006.

Stalman SE, Hellinga I, Wit JM, Hennekam RC, Kamp GA, Plötz FB. Growth failure in adolescents: etiology, the role of pubertal timing and most useful criteria for diagnostic workup. J Pediatr Endocrinol Metab. 2016;29(4):465-73. doi: 10.1515/jpem-2015-0267.

Binder G, Schweizer R, Blumenstock G, Braun R. Inhibin B plus LH vs GnRH agonist test for distinguishing constitutional delay of growth and puberty from isolated hypogonadotropic hypogonadism in boys.Clin Endocrinol (Oxf). 2015;82(1):100-5. doi: 10.1111/cen.12613.

Butenandt O. For Debate: Constitutional and Non-Constitutional Delay of Growth and Puberty. Pediatr Endocrinol Rev. 2017;15(2):132-135. doi: 10.17458/per.vol15.2017.but.fd.constitutionalnonconstitutional.

Beas F. Delayed constitutional puberty or hypogonadotrophic hypogonadism? Rev Med Chil. 1995;123(2):233-40.

Reinehr T, Hoffmann E, Rothermel J, Lehrian TJ, Brämswig J, Binder G. A New Model of Adult Height Prediction Validate in Boys with Constitutional Delay of Growth and Puberty. Horm Res Paediatr. 2019;91(3):186-194. doi: 10.1159/000499712.

Varimo T, Huopio H, Kariola L, et al. Letrozole versus testosterone for promotion of endogenous puberty in boys with constitutional delay of growth and puberty: a randomized controlled phase 3 trial. Lancet Child Adolesc Health. 2019;3(2):109-120. doi: 10.1016/S2352-4642(18)30377-8.

Howard SR. Genes underlying delayed puberty. Mol Cell Endocrinol. 2018;476:119-128. doi: 10.1016/j.mce.2018.05.001.

Giri D, Patil P, Blair J, et al. Testosterone Therapy Improves the First Year Height Velocity in Adolescent Boys with Constitutional Delay of Growth and Puberty. Int J Endocrinol Metab. 2017;15(2):e42311. doi: 10.5812/ijem.42311.

Lawaetz JG, Hagen CP, Mieritz MG, et al. Evaluation of 451 Danish boys with delayed puberty: diagnostic use of a new puberty nomogram and effects of oral testosterone therapy. J Clin Endocrinol Metab. 2015;100(4):1376-85. doi: 10.1210/jc.2014-3631.

Wit JM, Oostdijk W. Novel approaches to short stature therapy. Best Pract Res Clin Endocrinol Metab. 2015;29(3):353-66. doi: 10.1016/j.beem.2015.01.003.






Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© "Publishing House "Zaslavsky", 1997-2019

 

   Seo анализ сайта