Peculiarities of Hormonal Regulation of Blood Antioxidant Activity in Neuroendocrine Obesity at Different Stages of Sexual Maturation

D.K. Kuleshova, V.V. Davydov, Ye.A. Budreyko


The study is designed to establish the relationship between the rate of the induced blood lipid peroxidation and production of some hormones in adolescents. The investigations have not shown any significant alteration in the blood insulin content as well as in the daily catecholamine and melatonin excretion in the urine of adolescents in early puberty with the I–II degree of neuroendocrine obesity and without insulin resistance. The rate of the induced blood lipid peroxidation in them remains to be at the initial level. In adolescents of the saim age group hyperinsulinemia and an increased urinary excretion of catecholamine and melatonin occur against the background of the concomitant insulin resistance. The rate of the induced blood lipid peroxidation in such cases remains at the level of control values. Formation of hyperinsulinemia and an increased urinary excretion of norepinephrine and melatonin have been registered in late puberty in adolescents with neuroendocrine obesity of the I–II degree without insulin resistance. The emergence of these changes is accompanied by the maintenance of control va-lues of the induced blood lipid peroxidation. The similar changes in the endocrine parameters with attendant increase in the rate of the induced blood lipid peroxidation are occurred in adolescents of the above-mentioned age group with neuroendocrine obesity against the background of insulin resistance.


adolescents, sexual maturation, neuroendocrine obesity, insulin resistance, blood antioxidant activity


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