DOI: https://doi.org/10.22141/2224-0721.0.4.44.2012.177307

Peculiarities of Hormonal Regulation of Blood Antioxidant Activity in Neuroendocrine Obesity at Different Stages of Sexual Maturation

D.K. Kuleshova, V.V. Davydov, Ye.A. Budreyko

Abstract


The study is designed to establish the relationship between the rate of the induced blood lipid peroxidation and production of some hormones in adolescents. The investigations have not shown any significant alteration in the blood insulin content as well as in the daily catecholamine and melatonin excretion in the urine of adolescents in early puberty with the I–II degree of neuroendocrine obesity and without insulin resistance. The rate of the induced blood lipid peroxidation in them remains to be at the initial level. In adolescents of the saim age group hyperinsulinemia and an increased urinary excretion of catecholamine and melatonin occur against the background of the concomitant insulin resistance. The rate of the induced blood lipid peroxidation in such cases remains at the level of control values. Formation of hyperinsulinemia and an increased urinary excretion of norepinephrine and melatonin have been registered in late puberty in adolescents with neuroendocrine obesity of the I–II degree without insulin resistance. The emergence of these changes is accompanied by the maintenance of control va-lues of the induced blood lipid peroxidation. The similar changes in the endocrine parameters with attendant increase in the rate of the induced blood lipid peroxidation are occurred in adolescents of the above-mentioned age group with neuroendocrine obesity against the background of insulin resistance.

Keywords


adolescents, sexual maturation, neuroendocrine obesity, insulin resistance, blood antioxidant activity

References


Fernandes-Sanches A., Madrigal-Santillan E., Bantista M., Esquivel-Soto J., Morales-Gonsales A. Inflammation, Oxidative Stress, and Obesity // Int. J. Mol. Sci. — 2011. — Vol. 12. — P. 3117-3132.

Olusi S. Obesity is an independent risk factor for a plasma lipid peroxidation and depletion of erythrocyte cytoprotectic enzymes in humans // Int. J. of Obesity. — 2002. — Vol. 29, № 9. — P. 1156-1164.

Bondia-Pons I., Ryan L., Martinez J.A. Oxidative stress and inflammation interactions in human obesity // J. Physiol. Biochem. — 2012. — Vol. 68, № 1. — P. 130-139.

Xu X.J., Gauthier M.S., Hess D.T. et al. Isuline sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot specific changes in gene expression in adipose tissue // J. Lipid. Res. — 2012. — Vol. 4. — P. 792-801.

Molnar D., Decsi T., Koletsko B. Reduced antioxidant status in obese children with multimetabolic syndrome // Intern. J. of Obesity. — 2004. — Vol. 28. — P. 1197-1202.

Erdeve O., Siklar Z., Kocaturk P. et al. Antioxidant superoxide dismutase activity in obese children // Biol. Trace Elem. Res. — 2004. — Vol. 3. — P. 219-228.

Аверьянов А.П. Ожирение детей и подростков: клинико-метаболические особенности, лечение, прогноз и профилактика осложнений // Международный эндокринологический журнал. — 2009. — Т. 22, № 4. — С. 90-98.

Большова Е.В. Ранняя диагностика эндокринной патологии у детей и подростков // Здоров’я України. — 2007. — Т. 1, № 18. — С. 38-39.

Будрейко О.А., Нікітіна Л.Д., Чумак С.О. та ін. Діагностика інсулінорезистентності у дітей та підлітків з ожирінням: Методичні рекомендації. — К.: Нац. академія мед. наук України, МОЗ України, Укр. центр науков. мед. інформації та патентно-лізенційної роботи, 2011. — 24 с.

Давыдов В.В., Кашкалда Д.А., Голобородько А.В. Нормы содержания биологически активных веществ у детей и подростков: Справочник. — Харьков: Федорко, 2008. — 132 с.

Esterbauer H., Cheeseman K.H. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal // Methods in enzymology. — 1990. — Vol. 186. — P. 407-421.

Хижняк О.О. Метформин в профилактике метаболического синдрома у детей и взрослых // Международный эндокринологический журнал. — 2007. — Т. 10, № 4. — С. 43-47.

Polidori M.C., Savino K., Alunni G. et al. Plasma lipophilic antioxidants and malondialdehyde in congestive heart failure patients: relationship to disease severity // Free Radical. Biol. Med. — 2002. — Vol. 32, № 2. — P. 148-152.

Казимирко В., Мальцев В. Антиоксидантная система и ее функционирование в организме человека // Здоров’я України. — 2004. — № 98. — С. 41-43.

Reiter R.J., Tan D.X., Mayo J.C. et al. Melatonin as an antioxidant: biochemical mechanism and pathophysiological implications in humans // Acta Biochim. Pol. — 2003. — Vol. 50. — P. 1129-1146.

Geins M.A., Vargas M.A., Gomez T.F. et al. Effect of melatonin in the antioxidant defense system in locomotor muscles of the estuarine crab // Gen. and Compar. End. — 2010. — Vol. 166. — P. 72-82.

Kogawa M., Takano K., Asakawa K., Hizuka N., Tsushi-ma T., Shizume P. Insulin stimulation of somatomedin: a product in monolayer cultures of rat hepatocytes // Acta Endocrinol. — 1983. — Vol. 103. — P. 385-390.






Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© "Publishing House "Zaslavsky", 1997-2019

 

   Seo анализ сайта