DOI: https://doi.org/10.22141/2224-0721.0.3.43.2019.177185

Integral Assessment of Risk Factors for Metabolic Syndrome Develop-ment in Children and Adolescents with Obesity

G.N. Rakhimova, Sh.Sh. Azimova

Abstract


Metabolic syndrome (MS) causes early onset of atherosclerotic changes in vessels and of type 2 diabetes mellitus not only in the adults but also in adolescents that to predetermine onset and fast progression of some severe diseases resulting in early disability and death. The aim of the study — to carry out integral assessment of risk factors for MS development in children and adolescents with exogenous-constitutional obesity (ECO). Examination of 100 Uzbek children and adolescents aged from 6 to 16 years has shown high risk of MS development in obese patients with lipid profile disorders. Thus, MS onset risk is 8.5 times higher (26.5 ÷ 3.1) in patients with triglyceride (ЕП) level ≥ 1,7 mmol/l, 5.3 times higher (44.8 ÷ 8.5)
with high-density lipoproteins (HDL) level < 1.03 mmol/l, 3.5 times higher (50.0 ÷ 14.3) in НОМА-IR > 97 percentiles (1.23 — children/1.80 — adolescents), 3.1 times higher in patients with body mass index > 97 percentiles (45.2 ÷ 14.7), 2.6 times higher in
HbA1c > 6.7 % (40.0 ÷ 15.4) and 2.2 times higher — when atherogenity index > 3.0 (29.4 ÷ 13.6). Conclusion. Thus, almost complete MS-dependence was detected in TG level ≥ 1.7 mmol/l (RR = 8.47; EF = 88.19 %) and HDL level < 1.03 mmol/l (RR = 5.30; EF = 81.13 %).


References


Аверьянов А.П. Ожирение у детей и подростков: клинико-метаболические особенности, лечение, прогноз и профилактика осложнений // Международный эндокринологический журнал. — 2009. — № 4(22). — С. 11-14.

Бородина Б.О. Оценка инсулинорезистентности у детей и подростков с ожирением // Проблемы эндокринологии. — 2003. — Т. 49, № 6. — С. 8-9.

Бородина О.В. Ожирение у детей и подростков (факторы риска метаболического синдрома): Автореф. дис… канд. мед. наук. — М., 2004. — 29 с.

Шиган Е.Н. Методы прогнозирования и моделирования в социально-гигиенических исследованиях. — М., 1986. — 207 с.

Jose R., David T., Pietrobelli A., Allison D. Waist Circumfe-rence Percentiles in Nationally Representative Samples of African-American, European-American, and Mexican-American Children and Adolescents // J. Pediatr. — 2004. — Vol. 145. — P. 43-44.

Keskin M., Kurtoglu S., Kendirci M. Homeostasis Model Assessment Is More Reliable Than the Fasting Glucose/Insulin Ratio and Quantitative Insulin Sensitivity Check Index for Assessing Insulin Resistance Among Obese Children and Adolescents // Pediatrics. — 2005. — Vol. 115. — P. 500-503.

Lambert M., Paradis G., O’Loughlin J. Insulin resistance syndrome in a representative sample of children and adolescents from Quebec, Canada // Int. J. Obes. Relat. Metab. Disord. — 2004. — Vol. 28. — P. 833-841.

Sorensen K., Aksglaede L., Munch-Andersen T. et al. Sex Hormone-Binding Globulin Levels Predict Insulin Sensitivity, Disposition Index, and Cardiovascular Risk During Puberty // Diabetes Care. — 2009. — Vol. 32, № 5. — P. 909-914.

Zimmet P., Alberti G., Kaufman F., Tajima N. The metabolic syndrome in children and adolescents — an IDF consensus report // Pediatric Diabetes. — 2007. — Vol. 8. — Р. 299-306.






Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© "Publishing House "Zaslavsky", 1997-2019

 

   Seo анализ сайта