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Metabolic syndrome (MS) causes early onset of atherosclerotic changes in vessels and of type 2 diabetes mellitus not only in the adults but also in adolescents that to predetermine onset and fast progression of some severe diseases resulting in early disability and death. The aim of the study — to carry out integral assessment of risk factors for MS development in children and adolescents with exogenous-constitutional obesity (ECO). Examination of 100 Uzbek children and adolescents aged from 6 to 16 years has shown high risk of MS development in obese patients with lipid profile disorders. Thus, MS onset risk is 8.5 times higher (26.5 ÷ 3.1) in patients with triglyceride (ЕП) level ≥ 1,7 mmol/l, 5.3 times higher (44.8 ÷ 8.5)
with high-density lipoproteins (HDL) level < 1.03 mmol/l, 3.5 times higher (50.0 ÷ 14.3) in НОМА-IR > 97 percentiles (1.23 — children/1.80 — adolescents), 3.1 times higher in patients with body mass index > 97 percentiles (45.2 ÷ 14.7), 2.6 times higher in
HbA1c > 6.7 % (40.0 ÷ 15.4) and 2.2 times higher — when atherogenity index > 3.0 (29.4 ÷ 13.6). Conclusion. Thus, almost complete MS-dependence was detected in TG level ≥ 1.7 mmol/l (RR = 8.47; EF = 88.19 %) and HDL level < 1.03 mmol/l (RR = 5.30; EF = 81.13 %).
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