Comparative Effects of Hormone Replacement Therapy on Climacteric Symptoms and Sexual Function in Postmenopausal Women

F.A. Khaidarova, S.S. Nigmatova


Objective. To compare the effects of tibolone with traditional hormone replacement therapy (HRT) on climacteric symptoms and sexual function in postmenopausal women. Materials and Methods. 45 postmenopausal women applied to RSRPMCE were enrolled in the study. All women were divided into three groups. 15 women — members of first group received tibolone 2.5 mg, and one tablet of calcium and vitamin В preparation (calcium 500 mg and vitamin D 200 IU) daily. The second group consists of 15 women administered with estradiol 1.0 mg, dydrogesterone 5 mg (E/DG) and one tablet of calcium and vitamin В preparation daily. Control group consisted of 15 women received only one tablet of calcium and vitamin В preparation. Greene Climacteric Scale (GCS) was used to assess the efficacy of treatment of climacteric symptoms. Rosen’s Female Sexual Function Index (FSFI) was used for sexual function evaluation. Sex hormone binding globulin (SHBG), free estradiol index (FEI) and free testosterone index (FTI) were measured before and after treatment. The women were followed up for 3 months. Results. After treatment all GCS subscores improved in tibolone and E/DG groups (p < 0.001), except the sexual subscore in the
E/DG group. There were significant differences of FSFI in tibolone and E/DG groups versus control group after treatment. Tibolone, in comparison with E/DG, significantly lowered SHBG levels, increased FTI and FEI and improved the desire, arousal and orgasm sexual domains of the FSFI (p < 0.001). Conclusion. Tibolone may be an alternative to traditional HRT in the treatment of climacteric symptoms and sexual dysfunction in postmenopausal women.


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