Lifestyle Change as a Part of Complex Therapy of Chronic Systemic Inflammation in Metabolic Syndrome

I.P. Kaidashev


From a perspective of integrative physiology, metabolic syndrome (MS) can be regarded as a syntropy of internal diseases, based on the systemic inflammation, insulin resistance, lipotoxicity and other processes which depend on the activation of NF-kB. The general aspects of the systemic inflammation role in the development of MS, especially the participation of the adipose tissue in the proinflammatory cytokines production, have been observed. The data of modern clinical trials about impact of lifestyle change (increased physical activity, dietary restrictions) on the level of systemic inflammation in patients with MS have been presented. The necessity for randomized controlled clinical trials in order to determine the regimen of physical training and dietary restriction, aimed at the reduction of systemic inflammation in MS, has been concluded.


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