Lifestyle Change as a Part of Complex Therapy of Chronic Systemic Inflammation in Metabolic Syndrome

I.P. Kaidashev


From a perspective of integrative physiology, metabolic syndrome (MS) can be regarded as a syntropy of internal diseases, based on the systemic inflammation, insulin resistance, lipotoxicity and other processes which depend on the activation of NF-kB. The general aspects of the systemic inflammation role in the development of MS, especially the participation of the adipose tissue in the proinflammatory cytokines production, have been observed. The data of modern clinical trials about impact of lifestyle change (increased physical activity, dietary restrictions) on the level of systemic inflammation in patients with MS have been presented. The necessity for randomized controlled clinical trials in order to determine the regimen of physical training and dietary restriction, aimed at the reduction of systemic inflammation in MS, has been concluded.


Генделека Г.Ф., Генделека А.Н. Увеличение двигательной активности как неотъемлемый компонент профилактики и лечения ожирения // Международный эндокринологический журнал. — 2012. — № 1(41). — С. 62-66.

Кайдашев И.П. Эволюция понятия «метаболический синдром» и его современное значение // Український медичний часопис. — 2011, 2 червня [Електронний ресурс]. — Режим доступу:

Кайдашев И.П. NF-kB-сигнализация как основа развития системного воспаления, инсулинорезистентности, липотоксичности, сахарного диабета 2-го типа и атеросклероза // Международный эндокринологический журнал. — 2011. — № 3. — С. 35-45.

Кайдашев І.П. Активація NF-kB при метаболічному синдромі // Фізіологічний журнал. — 2012. — T. 58, № 1. — С. 93-101.

Aronson D., Bartha P., Zinder O., Kerner A., Markiewicz W., Avizohar O. et al. Obesity is the major determinant of elevated

C-reactive protein in subjects with the metabolic syndrome // Int. J. Obes. Relat. Metab. Disord. — 2004. — Vol. 28(5). — P. 674-679.

Ballou S.P., Kushner I. C-reactive protein and the acute phase response // Adv. Intern. Med. — 1992. — Vol. 37. — P. 313-336.

Bastard J.P., Jardel C., Bruckert E., Blondy P., Capeau J., Laville M. et al. Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss // J. Clin. Endocrinol. Metab. — 2000. — Vol. 85(9). — P. 3338-3342.

Bastard J.P., Jardel C., Bruckert E., Vidal H., Hainque B. Variations in plasma soluble tumour necrosis factor receptors after diet-induced weight loss in obesity // Diabetes Obes. Metab. — 2000. — 2(5). — P. 323-325.

Bruun J.M., Verdich C., Toubro S., Astrup A., Richelsen B. Association between measures of insulin sensitivity and circulating levels of interleukin-8, interleukin-6 and tumor necrosis factor-alpha. Effect of weight loss in obese men // Eur. J. Endocrinol. — 2003. — 148(5). — P. 535-542.

Cao J.J., Thach C., Manolio T.A., Psaty B.M., Kuller L.H., Chaves P.H. et al. C-reactive protein, carotid intima-media thickness, and incidence of ischemic stroke in the elderly // The Cardiovascular Health Study. Circulation. — 2003. — Vol. 108. — P. 166-170.

Chu N.F., Chang J.B., Shieh S.M. Plasma C-reactive protein concentrations in relation to 5-year body weight change among children: the Taipei Children Heart Study // Int. J. Obes. Relat. Metab. Disord. — 2003. — Vol. 27(6). — P. 735-739.

Church T.S., Barlow C.E., Earnest C.P., Kampert J.B., Priest E.L., Blair S.N. Associations between cardiorespiratory fitness and C-reactive protein in men // Arterioscler. Thromb. Vasc. Biol. — 2002. — 22(11). — P. 1869-1876.

Colbert L.H., Visser M., Simonsick E.M., Tracy R.P., Newman A.B., Kritchevsky S.B. et al. Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study // J. Am. Geriatr. Soc. — 2004. — Vol. 52(7). — P. 1098-1104.

Conraads V.M., Beckers P., Bosmans J., De Clerck L.S., Stevens W.J., Vrints C.J., Brutsaert D.L. Combined endurance/resistance training reduces plasma TNF-alpha receptor levels in patients with chronic heart failure and coronary artery disease // Eur. Heart J. — 2002. — Vol. 23(23). — P. 1854-1860.

DIAMAP: Road Map for Diabetes Research in Europe // Roadmap Report. — September 2010. — 198 p.

Forouhi N.G., Sattar N., McKeigue P.M. Relation of C-reactive protein to body fat distribution and features of the metabolic syndrome in Europeans and South Asians // Int. J. Obes. Relat. Metab. Disord. — 2001. — Vol. 25(9). — P. 1327-1331.

Gabay C., Kushner I. Acute-phase proteins and other systemic responses to inflammation // N. Engl. J. Med. — 1999. — Vol. 340. — P. 448-454.

Gallistl S., Sudi K.M., Aigner R., Borkenstein M. Changes in serum interleukin-6 concentrations in obese children and adolescents during a weight reduction program // Int. J. Obes. Relat. Metab. Disord. — 2001. — Vol. 25(11). — P. 1640-1643.

Geffken D.F., Cushman M., Burke G.L., Polak J.F., Sakkinen P.A., Tracy R.P. Association between physical activity and markers of inflammation in a healthy elderly population // Am. J. Epidemiol. — 2001. — Vol. 153(3). — P. 242-250.

Gielen S., Adams V., Möbius-Winkler S., Linke A., Erbs S., Yu J. et al. Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure // J. Am. Coll. Cardiol. — 2003. — 42(5). — P. 861-868.

Giugliano F., Esposito K., Di Palo C., Ciotola M., Giugliano G., Marfella R. et al. Erectile dysfunction associates with endothelial dysfunction and raised proinflammatory cytokine levels in obese men // J. Endocrinol. Invest. — 2004. — 27(7). — P. 665-669.

Greiwe J.S., Cheng B., Rubin D.C., Yarasheski K.E., Semenkovich C.F. Resistance exercise decreases skeletal muscle tumor necrosis factor alpha in frail elderly humans // FASEB J. — 2001. — Vol. 15(2). — P. 475-482.

Guerrero-Romero F., Rodríguez-Morán M. Relation of C-reactive protein to features of the metabolic syndrome in normal glucose tolerant, impaired glucose tolerant, and newly diagnosed type 2 diabetic subjects // Diabetes Metab. — 2003. — 29(1). — P. 65-71.

Heilbronn L.K., Noakes M., Clifton P.M. Energy restriction and weight loss on very-low-fat diets reduce C-reactive protein concentrations in obese, healthy women // Arterioscler. Thromb. Vasc. Biol. — 2001. — 21(6). — P. 968-970.

Heinrich P.C., Castell J.V., Andus T. Interleukin-6 and the acute phase response // Biochem. J. — 1990. — Vol. 265(3). — P. 621-636.

Kershaw E.E., Flier J.S. Adipose tissue as an endocrine organ // J. Clin. Endocrinol. Metab. — 2004. — Vol. 89(6). — P. 2548-2556.

King D.E., Carek P., Mainous A.G. III, Pearson W.S. Inflammatory markers and exercise: differences related to exercise type // Med. Sci. Sports Exerc. — 2003. — Vol. 35(4). — P. 575-581.

Milani R.V., Lavie C.J., Mehra M.R. Reduction in C-reactive protein through cardiac rehabilitation and exercise training // J. Am. Coll. Cardiol. — 2004. — 43(6). — P. 1056-1061.

Mohamed-Ali V., Goodrick S., Bulmer K., Holly J.M., Yudkin J.S., Coppack S.W. Production of soluble tumor necrosis factor receptors by human subcutaneous adipose tissue in vivo // Am. J. Physiol. — 1999. — Vol. 277. — P. 971-975.

Moldoveanu A.I., Shephard R.J., Shek P.N. The cytokine response to physical activity and training // Sports Med. — 2001. — 31(2). — P. 115-144.

Morley J.J., Kushner I. Serum C-reactive protein levels in disease // Ann. N. Y. Acad. Sci. — 1982. — Vol. 389. — P. 406-418.

Nicklas B.J., You T., Pahor M. Behavioural treatments for chronic systemic inflammation: effects of dietary weight loss and exercise training // CMAJ. — 2005. — Vol. 172(9). — P. 1199-1209.

Olusi S.O., Al-Awadhi A., Abraham M. Relations of serum interleukin 18 levels to serum lipid and glucose concentrations in an apparently healthy adult population // Horm. Res. — 2003. — Vol. 60(1). — P. 29-33.

Ouchi N., Kihara S., Funahashi T., Nakamura T., Nishida M., Kumada M. et al. Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue // Circulation. — 2003. — Vol. 107(5). — P. 671-674.

Pahor M., Franse L.V., Deitcher S.R., Cushman W.C., Johnson K.C., Shorr R.I. et al. Fosinopril versus amlodipine comparative treatments study: a randomized trial to assess effects on plasminogen activator inhibitor-1 // Circulation. — 2002. — 105. — P. 457-461.

Pearson T.A., Mensah G.A., Alexander R.W., Anderson J.L., Cannon R.O. III, Criqui M. et al. Centers for Disease Control and Prevention; American Heart Association. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association // Circulation. — 2003. — Vol. 107. — P. 499-511.

Pischon T., Hankinson S.E., Hotamisligil G.S., Rifai N., Rimm E.B. Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers // Obes. Res. — 2003. — Vol. 11(9). — P. 1055-1064.

Pradhan A.D., Manson J.E., Rifai N., Buring J.E., Rid-ker P.M. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus // JAMA. — 2001. — Vol. 286. — P. 327-334.

Rauramaa R., Halonen P., Väisänen S.B., Lakka T.A., Schmidt-Trucksäss A., Berg G. et al. Effects of aerobic physical exercise on inflammation and atherosclerosis in men: the DNASCO Study: a six-year randomized, controlled trial // Ann. Intern. Med. — 2004. — Vol. 140(12). — P. 1007-1014.

Ridker P.M. High-sensitivity C-reactive protein, inflammation, and cardiovascular risk: from concept to clinical practice to clinical benefit // Am. Heart J. — 2004. — Vol. 148 (Suppl. 1). — P. 19-26.

Ridker P.M., Cannon C.P., Morrow D., Rifai N., Rose L.M., McCabe C.H. et al. Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) Investigators. C-reactive protein levels and outcomes after statin therapy // N. Engl. J. Med. — 2005. — P. 35220-3528.

Rönnemaa T., Pulkki K., Kaprio J. Serum soluble tumor necrosis factor-alpha receptor 2 is elevated in obesity but is not related to insulin sensitivity: a study in identical twins discordant for obesity // J. Clin. Endocrinol. Metab. — 2000. — Vol. 85(8). — P. 2728-2732.

Ryan A.S., Nicklas B.J. Reductions in plasma cytokine levels with weight loss improve insulin sensitivity in overweight and obese postmenopausal women // Diabetes Care. — 2004. — Vol. 27(7). —

P. 1699-1705.

Saijo Y., Kiyota N., Kawasaki Y., Miyazaki Y., Kashimura J., Fukuda M. et al. Relationship between C-reactive protein and visceral adipose tissue in healthy Japanese subjects // Diabetes Obes. Metab. — 2004. — Vol. 6(4). — P. 249-258.

Trøseid M., Lappegård K.T., Claudi T., Damås J.K., Mørkrid L., Brendberg R. et al. Exercise reduces plasma levels of the chemokines MCP-1 and IL-8 in subjects with the metabolic syndrome // Eur. Heart J. — 2004. — Vol. 25(4). — P. 349-355.

Tsukui S., Kanda T., Nara M., Nishino M., Kondo T., Kobayashi I. Moderate-intensity regular exercise decreases serum tumor necrosis factor-alpha and HbA1c levels in healthy women // Int. J. Obes. Relat. Metab. Disord. — 2000. — 24(9). — P. 1207-1211.

Vasan R.S., Sullivan L.M., Roubenoff R., Dinarello C.A., Harris T., Benjamin E.J. et al. Framingham Heart Study. Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study // Circulation. — 2003. — Vol. 107. — P. 1486-1491.

Wannamethee S.G., Lowe G.D., Whincup P.H., Rumley A., Walker M., Lennon L. Physical activity and hemostatic and inflammatory variables in elderly me // Circulation. — 2002. — Vol. 105(15). — P. 1785-1790.

Wegge J.K., Roberts C.K., Ngo T.H., Barnard R.J. Effect of diet and exercise intervention on inflammatory and adhesion molecules in postmenopausal women on hormone replacement therapy and at risk for coronary artery disease // Metabolism. — 2004. — 53(3). — P. 377-381.

Weisberg S.P., McCann D., Desai M., Rosenbaum M.,

Leibel R.L., Ferrante A.W. Jr. Obesity is associated with macrophage accumulation in adipose tissue // J. Clin. Invest. — 2003. — Vol. 112(12). — P. 1796-1808.

Winkler G., Kiss S., Keszthelyi L., Sápi Z., Ory I., Salamon F. et al. Expression of tumor necrosis factor (TNF)-alpha protein in the subcutaneous and visceral adipose tissue in correlation with adipocyte cell volume, serum TNF-alpha, soluble serum TNF-receptor-2 concentrations and C-peptide level // Eur. J. Endocrinol. — 2003. — Vol. 149(2). — P. 129-135.

Xydakis A.M., Case C.C., Jones P.H., Hoogeveen R.C., Liu M.Y., Smith E.O. et al. Adiponectin, inflammation, and the expression of the metabolic syndrome in obese individuals: the impact of rapid weight loss through caloric restriction // J. Clin. Endocrinol. Metab. — 2004. — Vol. 89(6). — P. 2697-2703.

Yang R.-Z., Lee M.-J., Hu H. et al. Acute-phase protein serum amyloid A (SAA) is a pro-inflammatory adipocytokine in humans [abstract] // Diabetes. — 2004. — Vol. 53. — P. 12.

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