DOI: https://doi.org/10.22141/2224-0721.0.2.42.2012.176865

Impact of Conservative Treatment of Toxic Goiter on Body State of Women of Childbearing Age

N.B. Ubaydullayeva, D.M. Khakimdzhanova

Abstract


There was processed the archive data, there were selected women aged 17–39 years which received conservative treatment for toxic goiter in 2000–2011 on the base of clinic of Republican Specialized Scientific and Practical Medical Center of Endocrinology. Women were divided into 3 groups: first group — compensated thyrotoxicosis (n = 22), second one — decompensated thyrotoxicosis (n = 40), third group — controls, healthy women (n = 15).
Levels of thyroxin, triiodothyronine, thyrotrophic hormone, thyroperoxidase antibodies, luteinizing hormone, follicle-stimulating hormone, prolactin, estradiol were investigated on 5–6th days of menstrual cycle.
Endocrinous ophthalmopathy was observed in 22 (55 %) of patients with toxic goiter in compensated thyrotoxicosis, ciliary arrhythmia — in 5 (12.5 %), osteopenia — in 3 (7.5 %), osteoporosis — in 5 (12.5 %). In group with compensated thyrotoxicosis endocrinous ophthalmopathy was diagnosed in 4 (18.2 %) patients, osteopenia — in 2 (9.1 %), there were no patients with ciliary arrhythmia and osteoporosis.
Two (3.2 %) women suffered from chronic hepatitis, 5 (8.1 %) — from chronic pyelonephritis, 13 (21 %) — asthenoneurotic syndrome, 8 (13 %) — anxiophobic syndrome. In 5 (8.1 %) patients there was diagnosed chronic adnexitis, in 3 (4.8 %) — bacterial vaginosis, in 2 (3.2 %) — chronic cervicitis, 2 (3.2 %) women suffered from hysteromyoma.
In 16 (72.7 %) women from first group menstrual cycle was normal, in 3 (13.6 %) there was observed dysmenorrhea, in 3 (13.6 %) — hypermenorrhea, other disorders of menstrual cycle were not detected. Normal menstrual cycle was observed in14 (35 %) patients of second group, secondary amenorrhea — in 5 (12.5 %), opsomenorrhea — in 5 (12.5 %), hypermenorrhea — in 3 (7.5 %), hypomenorrhea — in 5 (12.5 %), polymenorrhea — in 2 (5 %), dysmenorrheal — in 6 (15 %) women.
Levels of T3, T4 and TTH in blood serum of first-group patients were within reference ranges whereas in second-group patients T3, T4 level was significantly higher, and TTH — lower as against controls, that testifies to decompensated thyrotoxicosis.
Concentration of thyroperoxidase antibodies in first-group patients was 9,7 ± 1,3 IU/ml, in second-group patients — 13,9 ± 1,2 IU/ml.
Against the background of compensated thyrotoxicosis 11 (17.7 %) patients with toxic goiter became pregnant. There was observed term labor and in all patients — without complications. All newborns were full-term, with good growth indices and score 8–9 by Apgar test, level of thyrotrophic hormone in blood on fifth day of life was normal.


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