Aspects of testosterone replacement therapy in men with type 2 diabetes mellitus and testosterone deficiency
Background. Testosterone deficiency is a medical condition that adversely affects male sexuality, reproduction, general health and quality of life. Testosterone therapy can improve the symptoms of testosterone deficiency and possibly stop the development of comorbid diseases. The purpose of the study is to determine the safety and side effects of substitution testosterone therapy in men with type 2 diabetes mellitus and testosterone deficiency. Materials and methods. Testosterone replacement therapy was carried out in 89 men aged 36–72 years with type 2 diabetes mellitus (duration from 1 to 18 years) and androgen deficiency: first group (35 patients) received testosterone undecanoate (1000 mg), second group (54 individuals) — 1 ml of an oil solution (250 mg) of a mixture of testosterone esters. Results. In the examined patients of the first group, the average values of erythrocytes, hemoglobin and hematocrit after the end of the observation period did not change significantly. Mean prostatespecific antigen level 9 months after the initiation of testosterone therapy increased by less than 10 % of the baseline, from 1.48 ± 0.26 ng/ml to 1.62 ± 0.20 ng/ml (p > 0.05). An increase in the volume of the prostate gland was nonsignificant: 32.1 ± 1.9 cm3 before the start of treatment vs 35.7 ± 1.9 cm3 in 9 months. In men of the second group, the average rates of erythrocytes, hemoglobin and hematocrit after the completion of testosterone replacement therapy did not change significantly. The mean prostatespecific antigen values 9 months after the initiation of testosterone therapy in patients of the second group remained virtually unchanged: 1.22 ± 0.30 ng/ml prior to therapy and 1.24 ± 0.20 ng/ml 9 months after (p > 0.1). An increase in the prostate volume in the examined patients was nonsignificant: 28.4 ± 2.2 cm3 before the start of treatment vs 31.6 ± 1.6 cm3 in 9 months. Conclusions. The results showed that the use of testosterone with different duration of action in men with diabetes mellitus is an effective and safe method.
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Camacho EM, Huhtaniemi IT, O’Neill TW, et al. Age-associated changes in hypothalamic-pituitary-testicular function in middle-aged and older men are modified by weight change and lifestyle factors: longitudinal results from the European Male Ageing Study. Eur J Endocrinol. 2013 Feb 20;168(3):445-55. doi: 10.1530/EJE-12-0890.
Kapoor D, Aldred H, Clark S, Channer KS, Jones TH. Clinical and biochemical assessment of hypogonadism in men with type 2 diabetes: correlations with bioavailable testosterone and visceral adiposity. Diabetes Care. 2007 Apr;30(4):911-7. doi: 10.2337/dc06-1426.
Hackett G, Heald AH, Sinclair A, Jones PW, Strange RC, Ramachandran S. Serum testosterone, testosterone replacement therapy and all-cause mortality in men with type 2 diabetes: retrospective consideration of the impact of PDE5 inhibitors and statins. Int J Clin Pract. 2016 Mar;70(3):244-53. doi: 10.1111/ijcp.12779.
Dhindsa S, Prabhacar S, Sethi M, Bandyopadhyay A, Chaudhuri A, Dandona P. Frequent occurrence of hypogonadotropic hypogonadism in type 2 diabetes. J Clin Endocrinol Metab. 2004 Nov;89(11):5462-8. doi: 10.1210/jc.2004-0804.
Bhasin S, Pencina M, Jasuja GK, et al. Reference Ranges for Testosterone in Men Generated Using Liquid Chromatography Tandem Mass Spectrometry in a Community-Based Sample of Healthy Nonobese Young Men in the Framingham Heart Study and Applied to Three Geographically Distinct Cohorts. J Clin Endocr Metab. 2011;96(8):2430-2439. doi: 10.1210/jc.2010-3012.
Bhasin S, Cunningham GR, Hayes FJ, et al. Testosterone Therapy in Men with Androgen Deficiency Syndromes: An Endocrine Society Clinical Practice Guideline. J Clin Endocr Metab. 2010;95(6):2536-2559. doi: 10.1210/jc.2009-2354.
Hackett G, Cole N, Bhartia M, Kennedy D, Raju J, Wilkinson P. Testosterone replacement therapy with long-acting testosterone undeconoate improves sexual function and quality of life parameters vs. placebo in a population of men with type 2 diabetes. J Sex Med. 2013 Jun;10(6):1612-27. doi: 10.1111/jsm.12146.
Hackett G, Cole N, Bhartia M, et al. The response to testosterone undecanoate in men with type 2 diabetes is dependent on achieving threshold serum levels (the BLAST study). Int J Clin Pract. 2014 Feb;68(2):203-15. doi: 10.1111/ijcp.12235.
Jones TH, Arver S, Behre HM, et al. Testosterone replacement in hypogonadal men with type 2 diabetes and/or metabolic syndrome (the TIMES2 study). Diabetes Care. 2011 Apr;34(4):828-37. doi: 10.2337/dc10-1233.
Heufelder AE, Saad F, Bunck MC, Gooren L. Fifty-two-week treatment with diet and exercise plus transdermal testosterone reverses the metabolic syndrome and improves glycemic control in men with newly diagnosed type 2 diabetes and subnormal plasma testosterone. J Androl. 2009 Nov-Dec;30(6):726-33. doi: 10.2164/jandrol.108.007005.
Hackett G, Cole N, Bhartia M, et al. Testosterone replacement therapy improves metabolic parameters in hypogonadal men with type 2 diabetes but not in men with coexisting depression: the BLAST study. J Sex Med. 2014 Mar;11(3):840-56. doi: 10.1111/jsm.12404.
Hackett G, Cole N, Deshpande A, et al. The BLAST study: treating hypogonadism in type 2 diabetes with long acting testosterone undecanoate versus placebo significantly improves HbA1c, waist circumference, aging male symptom scores and all sexual function domains of the IIEF. Results continue to improve for 12 to 18 months. Presented at the European Society of Sexual Medicine meeting, Milan (2011).
Coviello AD, Kaplan B, Lakshman KM, Chen T, Singh AB, Bhasin S.Effects of graded doses of testosterone on erythropoiesis in healthy young and older men. J Clin Endocrinol Metab. 2008 Mar;93(3):914-9. doi: 10.1210/jc.2007-1692.
Fernandez-Balsells MM, Murad MH, Lane M, et al. Clinical review 1: Adverse effects of testosterone therapy in adult men: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2010 Jun;95(6):2560-75. doi: 10.1210/jc.2009-2575.
Endogenous Hormones and Prostate Cancer Collaborative Group, Roddam AW, Allen NE, Appleby P, Key TJ. Endogenous sex hormones and prostate cancer: a collaborative analysis of 18 prospective studies. J Natl Cancer Inst. 2008 Feb 6;100(3):170-83. doi: 10.1093/jnci/djm323.
Hoyos CM, Killick R, Yee BJ, Grunstein RR, Liu PY. Effects of testosterone therapy on sleep and breathing in obese men with severe obstructive sleep apnoea: a randomized placebo-controlled trial. Clin Endocrinol (Oxf). 2012 Oct;77(4):599-607. doi: 10.1111/j.1365-2265.2012.04413.x.
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