Endothelial dysfunction and methods of its treatment in clinical practice: the role of laser Doppler flowmetry (literature review)

О.B. Dynnyk, N.A. Marunchyn, S.Ye. Mostovyi


In this literature review, the etiology of endothelial dysfunction is described. Endothelial dysfunction is presented in noninfectious diseases of the 21st century and at the same moment is predictor of cardiovascular and cerebrovascular events, especially in patients with diabetes mellitus type 2. Laser Doppler flowmetry is comprehensive noninvasive method for primary evaluation of microcirculation, detection of endothelial injury, substantiation of infusion therapy, disease prognosis and management of the patients. Based on the results of laser Doppler flowmetry, according to the European guidelines, the type of circulation and possible etiological factors of endothelial injury are determined. It is also important to define the possible treatment of endothelial injury (mostly infusion therapy), since the effects of drugs on the pre- and postcapillar sphincter help determine whether the therapy was effectiveness/ineffective.


diabetes mellitus; endothelium; laser Doppler flowmetry; infusiology; review


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