DOI: https://doi.org/10.22141/2224-0721.14.6.2018.146069

Vitamin D status, frequency of its insufficiency and deficiency in women with polycystic ovary syndrome

I.V. Pankiv, O.O. Korytko

Abstract


Background. Many studies have investigated vitamin D status in women with polycystic ovary syndrome (PCOS), but there is no consensus on whether or not its serum levels are different between women with and without PCOS. Current evidence suggests an inverse association between vitamin D status and metabolic disturbances in PCOS. No studies have been conducted to evaluate vitamin D level in the blood serum of Ukrainian women with PCOS. Purpose of the study was to determine vitamin D level in the blood serum, and also the prevalence of its insufficiency and deficiency in women with PCOS as compared to the healthy women. Materials and methods. Forty five PCOS women and body mass index­ and age­matched 25 healthy controls were recruited in observational, cross­sectional study. Serum vitamin D concentrations less than 30 ng/ml were classified as insufficiency and vitamin D deficiency — with a concentration below 20 ng/ml. Correlations between metabolic parameters and vitamin D status were analyzed separately in patients and controls. Results. Significant differences were observed in serum vitamin D levels, as well as in the prevalence of its insufficiency and deficiency between patients with PCOS and healthy women (93.3 and 84.0 %, respectively). In PCOS women, we found significantly negative correlations of vitamin D levels with body mass index and dehydroepiandrosterone sulfate serum concentrations. Conclusions. We found differences in the absolute level of serum vitamin D and the prevalence of its deficiency in PCOS and healthy women, suggesting a specific role of vitamin D in the pathogenesis of PCOS. Since vitamin D deficiency prevalence is high, large intervention trials are needed to evaluate the effect of vitamin D supplementation in PCOS women.


Keywords


vitamin D; polycystic ovary syndrome

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