DOI: https://doi.org/10.22141/2224-0721.14.6.2018.146067

Frequency of cardiovascular complications in patients with type 2 diabetes mellitus depending on antihyperglycemic therapy

Z.G. Krushinska, T.Yu. Yuzvenko, V.I. Pankiv

Abstract


Background. The purpose of the study was to determine the frequency of cardiovascular complications in patients with type 2 diabetes mellitus (DM) depending on the type of antihyperglycemic therapy. Materials and methods. Patients were divided into 3 groups: first group — all patients with type 2 DM included in the study (n = 1999), second group were patients (n = 201) with DM with myocardial infarction from the first group, third group were patients with DM with stroke from the first group (n = 155). Results. It was found that actually every second patient in the second group had angina pectoris — 48.3 % that is 2.7 times higher of the same index in the first group (18.2 %) and 1.7 times — in the third group (29.0 %). Every fifth patient in the second and third groups had heart rhythm disorder (in the first group — 11.2 %, in the second group — 20.9 %, in the third group — 20.7 %), its incidence was highest in men of this group (27.7 and 23.1 %, respectively). Arterial hypertension is the third common in the structure of concomitant cardiovascular pathology in patients with DM, more often in patients of the third group (in the first group — 74.6 %, in the second group — 76.6 %, in the third group — 80.7 %), most often in women in every group (78.7, 84.3 and 84.4 %, respectively). Coronary artery bypass surgery is conducted in 38 patients, the proportion among other operative interventions is highest in the second group (in the first group — 11.9 %, in the second group — 12.7 %, in the third group — 9.8 %). Conclusions. The proportion of patients who received monotherapy with insulin preparations is highest in the second group (17.4 %), actually at one level — in the first and third groups (12.8 and 12.3 %, respectively). The majority of patients in the first group received monotherapy with oral hypoglycemic agents (56.2 against 46.2 % in the second group and 49.7 % — in the third group), due to an increase in the proportion of patients with insulin monotherapy. Every third patient in the second and third groups (34.3 and 34.8 %, respectively) received combined therapy with insulins and oral hypoglycemic preparations.


Keywords


type 2 diabetes mellitus; treatment; cardiovascular diseases

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