DOI: https://doi.org/10.22141/2224-0721.14.5.2018.142691

Hypoglycemia in patients with type 1 and type 2 diabetes mellitus: incidence and risk factors (review of literature)

S.I. Ismailov, A.V. Vodovskaya

Abstract


The review of literature considers questions of hypoglycemia as a limiting factor in the treatment of diabetes mellitus (DM). Most frequent risk factors of hypoglycemia in patients with type 1 DM are: HbA1с level, endogenous insulin deficiency, daily distribution of basal insulin doses, total daily insulin dose, DM duration. For patients with type 2 DM, the main risk factors of hypoglycemia are: HbA1c level, sex, age, DM duration, cerebrovascular diseases, kidney diseases, coronary heat disease, dementia, use of insulin in combination with sulfonylureas, dosages of sulfonylureas, total daily dose of insulin, sleep duration, day of week, intensity of daily physical activity.


Keywords


diabetes mellitus; hypoglycemia; review

References


UK Hypoglycemia Study Group. Risk of hypoglycemia in types 1 and 2 diabetes: effects of treatment modalities and their duration. Diabetologia. 2007;50(6):1140-1147. doi: 10.1007/s00125-007-0599-y.

Donnelly LA, Morris AD, Frier BM, et al. Frequency and predictors of hypoglycemia in type 1 diabetes and insulin-treated type 2 diabetes: a population-based study. Diabet Med. 2005;22(6):749-755. doi: 10.1111/j.1464-5491.2005.01501.x.

ADVANCE Collaborative Group, Patel A, MacMahon S, Chalmers J, et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 2008 Jun 12;358(24):2560-72. doi: 10.1056/NEJMoa0802987.

Action to Control Cardiovascular Risk in Diabetes Study Group, Gerstein HC, Miller ME, Byington RP, et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008 Jun 12;358(24):2545-59. doi: 10.1056/NEJMoa0802743.

Duckworth W, Abraira C, Moritz T, et al. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med. 2009 Jan 8;360(2):129-39. doi: 10.1056/NEJMoa0808431.

Whitmer RA, Karter AJ, Yaffe K, Quesenberrry CP, Jr, Selby JV. Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus. JAMA. 2009 Apr 15;301(15):1565-72. doi: 10.1001/jama.2009.460.

Perantie DC, Koller JM, Weaver PM, et al. Prospectively determined impact of type 1 diabetes on brain volume during development. Diabetes. 2011 Nov;60(11):3006-14. doi: 10.2337/db11-0589.

Perantie DC, Lim A, Wu J, et al. Effects of prior hypoglycemia and hyperglycemia on cognition in children with type 1 diabetes mellitus. Pediatr Diabetes. 2008 Apr;9(2):87-95. doi: 10.1111/j.1399-5448.2007.00274.x.

Seaquist ER, Anderson J, Childs B, et al. Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and The Endocrine Society. Diabetes Care. 2013 May;36(5):1384-95. doi: 10.2337/dc12-2480.

Husband AC, Crawford S, McCoy LA, Pacaud D. The effectiveness of glucose, sucrose, and fructose in treating hypoglycemia in children with type 1 diabetes. Pediatr Diabetes. 2010 May;11(3):154-8. doi: 10.1111/j.1399-5448.2009.00558.x.

Lane W, Bailey TS, Gerety G, et al. Effect of Insulin Degludec vs Insulin Glargine U100 on Hypoglycemia in Patients With Type 1 Diabetes: The SWITCH 1 Randomized Clinical Trial. JAMA. 2017;318(1):33-44. doi: 10.1001/jama.2017.7115.

Sako A, Yasunaga H, Matsui H, et al. Hospitalization for Hypoglycemia in Japanese Diabetic Patients: A Retrospective Study Using a National Inpatient Database, 2008-2012. Medicine (Baltimore). 2015 Jun;94(25):e1029. doi: 10.1097/MD.0000000000001029.

Languren G, Montiel T, Ramнrez-Lugo L, et al. Recurrent moderate hypoglycemia exacerbates oxidative damage and neuronal death leading to cognitive dysfunction after the hypoglycemic coma. J Cereb Blood Flow Metab. 2017;271678X17733640. doi: 10.1177/0271678X17733640.

Birkebaek NH, Drivvoll AK, Aakeson K, et al. Incidence of severe hypoglycemia in children with type 1 diabetes in the Nordic countries in the period 2008-2012: association with hemoglobin A1c and treatment modality. BMJ Open Diabetes Res Care. 2017 May 29;5(1):e000377. doi: 10.1136/bmjdrc-2016-000377.

Hanberger L, Samuelsson U, Holl RW, Fröhlich-Reiterer E, Åkesson K, Hofer S. Type 1 diabetes during adolescence: International comparison between Germany, Austria, and Sweden. Pediatr Diabetes. 2018;19(3):506-511. doi: 10.1111/pedi.12591.

Home P, Calvi-Gries F, Blonde L, Pilorget V, Berlingieri J, Freemantle N. Clinical correlates of hypoglycaemia over 4 years in people with type 2 diabetes starting insulin: An analysis from the CREDIT study. Diabetes Obes Metab. 2018 Apr;20(4):921-929. doi: 10.1111/dom.13179.

Ikeda Y, Kubo T, Oda E, Abe M, Tokita S. Incidence rate and patient characteristics of severe hypoglycemia in treated type 2 diabetes mellitus patients in Japan – retrospective DPC database analysis. J Diabetes Investig. 2018 Jul;9(4):925-936. doi: 10.1111/jdi.12778.

Cryer PE, Davis SN, Shamoon H. Hypoglycemia in diabetes. Diabetes Care. 2003;26(6):1902-12.

Boulin M, Diaby V, Tannenbaum C. Preventing Unnecessary Costs of Drug-Induced Hypoglycemia in Older Adults with Type 2 Diabetes in the United States and Canada. PLoS One. 2016 Sep 20;11(9):e0162951. doi: 10.1371/journal.pone.0162951.

Patell R, Nigmatoulline D, Bena J, Kim DG, Messinger-Rapport B, Lansang MC. Hyperglycemia and hypoglycemia in patients with diabetes in skilled nursing facilities. Endocr Pract. 2017;23(4):458-465. doi: 10.4158/EP161502.OR.

Porcellati F, Lin J, Lucidi Pб Bolli GB, Fanelli CG. Impact of patient and treatment characteristics on glycemic control and hypoglycemia in patients with type 2 diabetes initiated to insulin glargine or NPH: A post hoc, pooled, patient-level analysis of 6 randomized controlled trials. Medicine (Baltimore). 2017;96(5):e6022. doi: 10.1097/MD.0000000000006022.

Heller SR, Bergenstal RM, White WB, et al. Relationship of glycated haemoglobin and reported hypoglycaemia to cardiovascular outcomes in patients with type 2 diabetes and recent acute coronary syndrome events: The EXAMINE trial. Diabetes Obes Metab. 2017;19(5):664-671. doi: 10.1111/dom.12871.

Tarkun İ. Attitudes, wishes, and needs of diabetes patients and their relatives: Turkish data from the DAWN2 study. Turk J Med Sci. 2017;47(2):447-454. doi: 10.3906/sag-1509-67.

Kim HM, Seong JM, Kim J, et al. Risk of hospitalization for hypoglycemia among older Korean people with diabetes mellitus: Interactions between treatment modalities and comorbidities. Medicine (Baltimore). 2016;95(42):e5016. doi: 10.1097/MD.0000000000005016.

Wohland T, Holstein JD, Patzer OM, et al. New risk and protective factors for severe hypoglycaemia in people with type 1 diabetes. Nutr Metab Cardiovasc Dis. 2017;27(5):407-414. doi: 10.1016/j.numecd.2016.12.006.

Novodvorsky P, Bernjak A, Chow E, et al. Diurnal Differences in Risk of Cardiac Arrhythmias During Spontaneous Hypoglycemia in Young People With Type 1 Diabetes. Diabetes Care. 2017;40(5):655-662. doi: 10.2337/dc16-2177.

Ishtiak-Ahmed K, Carstensen B, Pedersen-Bjergaard U, Jørgensen ME. Incidence Trends and Predictors of Hospitalization for Hypoglycemia in 17,230 Adult Patients With Type 1 Diabetes: A Danish Register Linkage Cohort Study. Diabetes Care. 2017;40(2):226-232. doi: 10.2337/dc16-0862.

Deeb A, Al Qahtani N, Attia S, Al Suwaidi H, Nagelkerke N. Does Reducing Basal Insulin During Ramadan Fasting by Children and Adolescents with Type 1 Diabetes Decrease the Risk of Symptomatic Hypoglycemia? Diabetes Technol Ther. 2016;18(9):539-42. doi: 10.1089/dia.2016.0197.

Anarte MT, Carreira M, Machado A, et al. Identification of risk factors for suffering fear of hypoglycemia in type 1 diabetes mellitus patients. Scand J Psychol. 2014;55(6):554-7. doi: 10.1111/sjop.12158.

Driscoll KA, Raymond J, Naranjo D, Patton SR. Fear of Hypoglycemia in Children and Adolescents and Their Parents with Type 1 Diabetes. Curr Diab Rep. 2016;16(8):77. doi: 10.1007/s11892-016-0762-2.

Pontiroli AE, Miele L, Morabito A. Metabolic control and risk of hypoglycaemia during the first year of intensive insulin treatment in type 2 diabetes: systematic review and meta-analysis. Diabetes Obes Metab. 2012;14(5):433-46. doi: 10.1111/j.1463-1326.2011.01543.x.

Tharakan G, Behary P, Wewer Albrechtsen NJ, et al. Roles of increased glycaemic variability, GLP-1 and glucagon in hypoglycaemia after Roux-en-Y gastric bypass. Eur J Endocrinol. 2017;177(6):455-464. doi: 10.1530/EJE-17-0446.

Øhrstrøm CC, Worm D, Hansen DL. Postprandial hyperinsulinemic hypoglycemia after Roux-en-Y gastric bypass: an update. Surg Obes Relat Dis. 2017;13(2):345-351. doi: 10.1016/j.soard.2016.09.025.

Karter AJ, Warton EM, Lipska KJ, et al. Development and Validation of a Tool to Identify Patients With Type 2 Diabetes at High Risk of Hypoglycemia-Related Emergency Department or Hospital Use. JAMA Intern Med. 2017;177(10):1461-1470. doi: 10.1001/jamainternmed.2017.3844.

Wysham C, Bhargava A, Chaykin L, et al. Effect of Insulin Degludec vs Insulin Glargine U100 on Hypoglycemia in Patients With Type 2 Diabetes: The SWITCH 2 Randomized Clinical Trial. JAMA. 2017;318(1):45-56. doi: 10.1001/jama.2017.7117.

Klatt EC, Beatie C, Noguchi TT. Evaluation of death from hypoglycemia. Am J Forensic Med Pathol. 1988;9(2):122-5.

Parekh B. The mechanism of dead-in-bed syndrome and other sudden unexplained nocturnal deaths. Curr Diabetes Rev. 2009;5(4):210-5.

Snell-Bergeon JK, Wadwa RP. Hypoglycemia, diabetes, and cardiovascular disease. Diabetes Technol Ther. 2012 Jun;14 Suppl 1:S51-8. doi: 10.1089/dia.2012.0031.

Henriksen MM, Ferch L, Thorsteinsson B, Pedersen-Bjergaard U. Long-Term Prediction of Severe Hypoglycemia in Type 1 Diabetes: Is It Really Possible? J Diabetes Sci Technol. 2016;10(6):1230-1235. doi: 10.1177/1932296816664745.

Calhoun PM, Buckingham BA, Maahs DM, et al. Efficacy of an Overnight Predictive Low-Glucose Suspend System in Relation to Hypoglycemia Risk Factors in Youth and Adults With Type 1 Diabetes. J Diabetes Sci Technol. 2016;10(6):1216-1221. doi: 10.1177/1932296816645119.

McGill DE, Levitsky LL. Management of Hypoglycemia in Children and Adolescents with Type 1 Diabetes Mellitus. Curr Diab Rep. 2016;16(9):88. doi: 10.1007/s11892-016-0771-1.




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