The role of IL-17 in the pathogenesis of type 1 and type 2 diabetes mellitus in humans

Main Article Content

K.P. Zak
V.V. Popova

Abstract

The paper analyzes the latest publications on the biological and pathogenetic role of the recently discovered pro-inflammatory cytokine IL-17 secreted by the Th17 CD4+ T-cell clone in a healthy and ill persons. Given data indicate the key role of IL-17 in the pathogenesis of the majority of autoimmune diseases, especially type 1 and type 2 diabetes mellitus. Increased percentage of Th17 cells in the body and elevated level of the cytokine IL-17 is typical for patients with diabetes mellitus both type 1 and type 2. In addition, there is another subpopulation of CD4+ T-cells — CD4+CD25+FoxP3+ lymphocytes, called T-regulatory cells (Treg), inhibiting Th17 cells, and thus preventing the development of diabetes mellitus. Based on these data, a hypothesis of a balance between these two subpopulations of CD4+ T-cells in the body of a healthy person has been suggested. In diabetes mellitus an imbalance between Th17 and Treg cells develops in the direction of increasing the Th17 cell content and IL-17 level, which is accompanied by a syngeneic elevation in Th1 CD4+ T-proinflammatory cytokines. Obtaining more complete information on the properties of IL-17 in the future is of great importance for the development of new scientifically valid methods for the prevention and therapy of diabetes mellitus and other autoimmune diseases.

Article Details

How to Cite
Zak, K., and V. Popova. “The Role of IL-17 in the Pathogenesis of Type 1 and Type 2 Diabetes Mellitus in Humans”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), vol. 14, no. 5, Oct. 2018, pp. 514-21, doi:10.22141/2224-0721.14.5.2018.142690.
Section
Literature Review

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