The features of esophageal daily pH-monitoring depending on the clinical form of gastroesophageal reflux disease in type 2 diabetic patients

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Yo.I. Pichkar
Ye.S. Sirchak
M.P. Stan
O.T. Oleksyk

Abstract

Background. The purpose of the study was to determine the features of esophageal daily pH-monitoring depending on the clinical form of gastroesophageal reflux disease in type 2 diabetic patients. Material and methods. Eighty-two patients with type 2 diabetes mellitus and gastroesophageal reflux disease were examined. All patients underwent daily pH-monitoring. Results. The time percentage when esophageal pH was < 4 almost equally exceeded such parameter in the control group (31.7 ± 2.3 % in patients with the esophageal form of gastroesophageal reflux disease and 32.7 ± 2.9 % in patients with extra-esophageal form against 4.5 ± 0.3 % in the control group; p < 0.01). Conclusions. In type 2 diabetic patients with esophageal form of gastroesophageal reflux disease daily pH-monito­ring revealed pH < 4 in the esophagus mostly in vertical position, and in patients with extra-esophageal form — in horizontal position. The esophageal pH disturbance in type 2 diabetic patients with esophageal form of gastroesophageal reflux disease is associated with candida esophagitis, whereas in patients with extra-esophageal manifestations — with duodeno-gastro-esophageal reflux (r = 0.84; p < 0.01; r = 0.71; p < 0.05, respectively).

Article Details

How to Cite
Pichkar, Y., Y. Sirchak, M. Stan, and O. Oleksyk. “The Features of Esophageal Daily PH-Monitoring Depending on the Clinical Form of Gastroesophageal Reflux Disease in Type 2 Diabetic Patients”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), vol. 14, no. 5, Oct. 2018, pp. 488-92, doi:10.22141/2224-0721.14.5.2018.142685.
Section
Original Researches

References

Kon’kova LA, Kon’kov AV. Gastroesophageal reflux: extra-oesophageal manifestations. MIA Medical Bulletin. 2016;2(81):47-50. (in Russian).

Naumova VN, Maslak EE. Diabetes mellitus and dental health: problems of diagnosis and treatment of patients in dental clinics’ patients. Practical medicine. 2013;(70):10-14. (in Russian).

Stepanov IuM, Zakharash MP, Skrypnik IN, Gubskaia EV. The newest technologies in theoretical and practical gastroenterology. Zdorov’ja Ukrai'ny. 2016;(386-387):20-21. (in Russian).

Tkachenko VI. The draft unified clinical protocol for the management of type 2 diabetes mellitus at the stage of primary care (in accordance with international standards in 2012). Liky Ukrai'ny. 2012;(162):51-59. (in Ukrainian).

Fadeenko GD, Chernyshov VA. The injuries of gastroduodenal region in patients with diabetes mellitus: clinical and population prevalence aspects. Liky Ukrai'ny. 2011;(153):48-50. (in Ukrainian).

Lee SD, Keum B, Chun HJ, Bak YT. Gastroesophageal reflux disease in type II diabetes mellitus with or without peripheral neuropathy. J Neurogastroenterol Motil. 2011 Jul;17(3):274-8. doi: 10.5056/jnm.2011.17.3.274.

Katz PO, Gerson LB, Vela MF. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol. 2013 Mar;108(3):308-28; quiz 329. doi: 10.1038/ajg.2012.444.