Clinical experience of using herbal medicinal product Glucemedin in the comprehensive treatment of patients with type 2 diabetes mellitus
Background. The current task of treating patients with type 2 diabetes mellitus and dyslipoproteinemia is the analysis of efficiency of the combination of standard hypoglycemic agents with phytotherapeutic drugs, but information about the feature of their use requires clarification. The purpose was to evaluate the influence of treatment with a fixed combination of gymnema, banaba leaves and bitter melon extract together with sulfonylurea and metformin on the dynamics of the clinical state, carbohydrate and lipid metabolism in patients with diabetes mellitus type 2. Materials and methods. The study involved 40 patients (16 men) aged 61.7 ± 7.8 years with type 2 diabetes. All patients before the treatment and after 2 months underwent: general blood test, evaluation of glycated hemoglobin, creatinine, urea, bilirubin, alanine aminotransferase, aspartate aminotransferase, cholesterol, high-density lipoproteins, low-density lipoproteins, triglyce-rides, glucose levels. All patients were divided into four groups according to the basic hypoglycemic therapy: group 1 received metformin (n = 6); group 2 — metformin and gliclazide (n = 10); group 3 — metformin and glimepiride (n = 14). The dose of hypoglycemic drugs was not changed during the whole study, Glucemedin was additionally administered in a dose of 1 capsule three times a day during 2 months. In group 4 (controls; n = 10), standard hypoglycemic therapy was not modified. Results. The inclusion of Glucemedin in the treatment resulted in a statistically significant decrease in the level of glycemia, glycated hemoglobin, triglycerides and an increase in high-density lipoproteins, and did not affect the concentration of total cholesterol and low-density lipoproteins. Conclusions. The obtained results demonstrated that the efficacy of combining standard hypoglycemic therapy with Glucemedin are consequent of the interacting impact of these pharmacological agents on the investigated parameters, which justifies the expediency of its use in the treatment of patients with type 2 diabetes mellitus.
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