DOI: https://doi.org/10.22141/2224-0721.14.4.2018.140186

Evaluating the excretory function of solitary kidney in patients with urolithiasis on a background of type 2 diabetes mellitus

D.I. Kuprin, M.I. Bobryk, Yu.I. Komisarenko

Abstract


Background. The purpose was to study intrarenal hemodynamics and excretory function using dynamic renoscintigraphy in patients with urolithiasis of solitary kidney on a background of type 2 diabetes mellitus (DM). Materials and methods. The article presents the data of examination of 62 patients with acquired solitary kidney, who were divided into 3 groups: group 1 — 21 persons with nephrolithiasis of solitary kidney and concomitant type 2 DM; group 2 — 23 patients with nephrolithiasis of solitary kidney; group 3 was presented by 18 patients with “healthy” solitary kidney, which remained after nephrectomy. Biochemical blood tests and dynamic renoscintigraphy were performed. Results. In patients with solitary kidney in case of nephrolithiasis, renal venous hypertension is diagnosed, intraglomerular pressure increases and hyperfiltration and hypersecretion occur. In the presence of DM and its complications, peripheral vascular resistance in the kidney gradually increases with the decline of excretory function. Conclusions. Under conditional compensation of kidney function according to the biochemical blood indexes, in patients with nephrolithiasis of solitary kidney, during dynamic renoscintigraphy the significant negative changes are determined in the intrarenal blood flow and excretory kidney function, especially in patients with type 2 DM.


Keywords


solitary kidney; nephrolithiasis; renoscintigraphy; type 2 diabetes mellitus; functional state of the kidney; glome­rular filtration

References


Romero V, Akpinar H, Assimos DG. Kidney stones: a global picture of prevalence, incidence, and associated risk factors. Rev Urol. 2010 Spring;12(2-3):e86-96.

Lieske JC, Peña de la Vega LS, Slezak JM, et al. Renal stone epidemiology in Rochester, Minnesota: an update. Kidney Int. 2006 Feb;69(4):760-4. doi: 10.1038/sj.ki.5000150.

Dmytryshyn SP. Urolithiasis: epidemiology peculiarities in regional aspect. Urology. 2015;19(75):21-9. (in Ukrainian).

Spiridonenko VV. Violation of homoeostasis and functional state of only kidney, by the staggered urolithiasis. Urology. 2004;(2):12-15. (in Ukrainian).

Saucier NA, Sinha MK, Liang KV, et al. Risk factors for CKD in persons with kidney stones: a case-control study in Olmsted County, Minnesota. Am J Kidney Dis. 2010 Jan;55(1):61-8. doi: 10.1053/j.ajkd.2009.08.008.

Matjuha LF, Tytova TA, Buhanovs'ka TM, Smal' BO. Ukrainian experience of health care for patients with diabetes. Wiad Lek. 2016;69(3 pt 2):465-470. (in Ukrainian).

Mankovskyi BM, Larin OS, Bertayeva LV. Indexes of diabetes mellitus compensation in Ukraine. Results of Diacontrol research. Clinical Endocrinology and Endocrine Surgery. 2007;(4):46-48. (in Ukrainian).

Weinberg AE, Patel CJ, Chertow GM, Leppert JT. Diabetic Severity and Risk of Kidney Stone Disease. Eur Urol. 2014 Jan;65(1):242-7. doi: 10.1016/j.eururo.2013.03.026.

Reutens AT. Epidemiology of Diabetic Kidney Disease. Med Clin North Am. 2013 Jan;97(1):1-18. doi: 10.1016/j.mcna.2012.10.001.

Spiridonenko VV. Radionuclides researches at the nephrolithiasis of only kidney: the state of internal blood circulation. Urology. 2004;(1):70-74. (in Ukrainian).

Frolov A, Sagalevich A, Sernyak P, Chernikov A, Balka L. Comparative estimation of methods and results of treatment of urolithiasis of only kidney. Urologiya. 2013;17(66):51-55. (in Ukrainian).

Kundin VYu, Pospelov SV. Radiopharmaceuticals for visualization and evaluation of the functional state urinary system. Urology. 2012;16(61):58-64. (in Ukrainian).

Kundin VYu, Pospelov SV. Dynamic renoscintigraphy in the urologic practice. Urology. 2012;16(63):5-24. (in Ukrainian).

Low S, Zhang X, Wang J, et al. Long-term prospective observation suggests that glomerular hyperfiltration is associated with rapid decline in renal filtration function: A multiethnic study. Diab Vasc Dis Res. 2018 May 1:1479164118776465. doi: 10.1177/1479164118776465.

Boyko AI. About the functional state of only "healthy" kidney. Health of men. 2011;(4):136-139. (in Ukrainian).

Baron AD. Insulin resistance and vascular function. J Diabetes Complications. 2002 Jan-Feb;16(1):92-102.




Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© "Publishing House "Zaslavsky", 1997-2018

 

   Seo анализ сайта