Main Article Content
Background. Changes of vitamin D level and its influence on the indexes of carbohydrate metabolism compensation in patients with type 2 diabetes mellitus (DM) combined with non-alcoholic fatty liver disease (NAFLD) are studied not enough. Aim: to study vitamin D content in patients with type 2 DM and correlation of carbohydrate metabolism compensation, the state of lipid metabolism, levels of transaminases with vitamin D level. Materials and methods. Sixty patients with type 2 DM associated with NAFLD aged 48 to 80 (on the average 63.30 ± 0.89) years were examined. Among the surveyed persons, there were 40 women (67 %) and 20 men 20 (33 %). All patients were divided into two groups: group 1 (32 persons) consisted of patients with DM type 2 combined with NAFLD and osteoporosis; group 2 (28 people) — individuals with type 2 DM associated with NAFLD without osteoporosis. Results. The paper presents the results of the examined groups of patients (type 2 DM in combination with NAFLD with and without osteoporosis); vitamin D deficiency or insufficiency was detected, that is, none of the patients didn’t have an adequate supply of vitamin D. Patients from the above groups had dyslipidemia on a background of a low 25(OH)D content. The levels of total cholesterol, β-lipoproteins, triglycerides, low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol, as well as atherogenic index were statistically significantly increased with decreasing levels of vitamin D; therefore, there was an inverse correlation between the above indicators. Statistically significant differences were not found between the levels of total bilirubin, an indicator of thymol samples and the level of vitamin D. Conclusions. An increase was noted in transaminase concentration compared to their normative values, as well as a decrease in the De Ritis ratio with a simultaneous decrease in vitamin D content.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our edition uses the copyright terms of Creative Commons for open access journals.
Authors, who are published in this journal, agree with the following terms:
- The authors retain rights for authorship of their article and grant to the edition the right of first publication of the article on a Creative Commons Attribution 4.0 International License, which allows others to freely distribute the published article, with the obligatory reference to the authors of original works and original publication in this journal.
- Directing the article for the publication to the editorial board (publisher), the author agrees with transmitting of rights for the protection and using the article, including parts of the article, which are protected by the copyrights, such as the author’s photo, pictures, charts, tables, etc., including the reproduction in the media and the Internet; for distributing; for the translation of the manuscript in all languages; for export and import of the publications copies of the writers’ article to spread, bringing to the general information.
- The rights mentioned above authors transfer to the edition (publisher) for the unlimited period of validity and on the territory of all countries of the world.
- The authors guarantee that they have exclusive rights for using of the article, which they have sent to the edition (publisher). The edition (the publisher) is not responsible for the violation of given guarantees by the authors to the third parties.
- The authors have the right to conclude separate supplement agreements that relate to non-exclusive distribution of their article in the form in which it had been published in the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
- The policy of the journal permits and encourages the publication of the article in the Internet (in institutional repository or on a personal website) by the authors, because it contributes to productive scientific discussion and a positive effect on efficiency and dynamics of the citation of the article.
Cho NH, Shaw JE, Karuranga S, et al. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018 Apr;138:271-281. doi: 10.1016/j.diabres.2018.02.023.
Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30. doi: 10.1210/jc.2011-0385.
Dutta D, Mondal SA, Choudhuri S, et al. Vitamin-D supplementation in prediabetes reduced progression to type 2 diabetes and was associated with decreased insulin resistance and systemic inflammation: an open label randomized prospective study from Eastern India. Diabetes Res Clin Pract. 2014 Mar;103(3):e18-23. doi: 10.1016/j.diabres.2013.12.044.
Rizzoli R, Boonen S, Brandi ML, et al. Vitamin D supplementation in elderly or postmenopausal women: a 2013 update of the 2008 recommendations from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Curr Med Res Opin. 2013 Apr;29(4):305-13. doi: 10.1185/03007995.2013.766162.
Kanis JA, McCloskey EV, Johansson H, et al. European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int. 2013 Jan;24(1):23-57. doi: 10.1007/s00198-012-2074-y.
Pankiv IV. Effect of vitamin D supplementation on insulin resistance in patients with hypothyroidism. Mìžnarodnij endokrinologìčnij žurnal. 2017;13(6):455-458. doi: 10.22141/2224-07184.108.40.2067.112892.
Mai XM, Chen Y, Camargo CA Jr, Langhammer A. Cross-sectional and prospective cohort study of serum 25-hydroxyvitamin D level and obesity in adults: The HUNT study. Am J Epidemiol. 2012 May 15;175(10):1029-36. doi: 10.1093/aje/kwr456.
Saneei P, Salehi-Abargouei A, Esmaillzadeh A. Serum 25-hydroxy vitamin D levels in relation to body mass index: a systematic review and meta-analysis. Obes Rev. 2013 May;14(5):393-404. doi: 10.1111/obr.12016.
Robberecht H, De Bruyne T, Hermans N. Biomarkers of the Metabolic Syndrome: Influence of Caloric Intake, Various Food Groups and Vitamins. Journal of Food and Nutrition Research. 2017;5(2):101-109. doi: 10.12691/jfnr-5-2-5.
Deleskog A, Hilding A, Brismar K, Hamsten A, Efendic S, Östenson CG. Low serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance. Diabetologia. 2012 Jun;55(6):1668-78. doi: 10.1007/s00125-012-2529-x.
Pinelli NR, Jaber LA, Brown MB, Herman WH. Serum 25-hydroxyvitamin D and insulin resistance, metabolic syndrome, and glucose intolerance among Arab Americans. Diabetes Care. 2010 Jun;33(6):1373-5. doi: 10.2337/dc09-2199.
Miller PD. Vitamin D, calcium, and cardiovascular mortality: a perspective from a plenary lecture given at the annual meeting of the American Association of Clinical Endocrinologists. Endocr Pract. 2011 Sep-Oct;17(5):798-806. doi: 10.4158/EP11203.RA.