The relationship of vitamin D with compensation of carbohydrate metabolism in patients with type 2 diabetes mellitus combined with non-alcoholic fatty liver disease
Background. Changes of vitamin D level and its influence on the indexes of carbohydrate metabolism compensation in patients with type 2 diabetes mellitus (DM) combined with non-alcoholic fatty liver disease (NAFLD) are studied not enough. Aim: to study vitamin D content in patients with type 2 DM and correlation of carbohydrate metabolism compensation, the state of lipid metabolism, levels of transaminases with vitamin D level. Materials and methods. Sixty patients with type 2 DM associated with NAFLD aged 48 to 80 (on the average 63.30 ± 0.89) years were examined. Among the surveyed persons, there were 40 women (67 %) and 20 men 20 (33 %). All patients were divided into two groups: group 1 (32 persons) consisted of patients with DM type 2 combined with NAFLD and osteoporosis; group 2 (28 people) — individuals with type 2 DM associated with NAFLD without osteoporosis. Results. The paper presents the results of the examined groups of patients (type 2 DM in combination with NAFLD with and without osteoporosis); vitamin D deficiency or insufficiency was detected, that is, none of the patients didn’t have an adequate supply of vitamin D. Patients from the above groups had dyslipidemia on a background of a low 25(OH)D content. The levels of total cholesterol, β-lipoproteins, triglycerides, low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol, as well as atherogenic index were statistically significantly increased with decreasing levels of vitamin D; therefore, there was an inverse correlation between the above indicators. Statistically significant differences were not found between the levels of total bilirubin, an indicator of thymol samples and the level of vitamin D. Conclusions. An increase was noted in transaminase concentration compared to their normative values, as well as a decrease in the De Ritis ratio with a simultaneous decrease in vitamin D content.
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Cho NH, Shaw JE, Karuranga S, et al. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018 Apr;138:271-281. doi: 10.1016/j.diabres.2018.02.023.
Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30. doi: 10.1210/jc.2011-0385.
Dutta D, Mondal SA, Choudhuri S, et al. Vitamin-D supplementation in prediabetes reduced progression to type 2 diabetes and was associated with decreased insulin resistance and systemic inflammation: an open label randomized prospective study from Eastern India. Diabetes Res Clin Pract. 2014 Mar;103(3):e18-23. doi: 10.1016/j.diabres.2013.12.044.
Rizzoli R, Boonen S, Brandi ML, et al. Vitamin D supplementation in elderly or postmenopausal women: a 2013 update of the 2008 recommendations from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Curr Med Res Opin. 2013 Apr;29(4):305-13. doi: 10.1185/03007995.2013.766162.
Kanis JA, McCloskey EV, Johansson H, et al. European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int. 2013 Jan;24(1):23-57. doi: 10.1007/s00198-012-2074-y.
Pankiv IV. Effect of vitamin D supplementation on insulin resistance in patients with hypothyroidism. Mìžnarodnij endokrinologìčnij žurnal. 2017;13(6):455-458. doi: 10.22141/2224-07126.96.36.1997.112892.
Mai XM, Chen Y, Camargo CA Jr, Langhammer A. Cross-sectional and prospective cohort study of serum 25-hydroxyvitamin D level and obesity in adults: The HUNT study. Am J Epidemiol. 2012 May 15;175(10):1029-36. doi: 10.1093/aje/kwr456.
Saneei P, Salehi-Abargouei A, Esmaillzadeh A. Serum 25-hydroxy vitamin D levels in relation to body mass index: a systematic review and meta-analysis. Obes Rev. 2013 May;14(5):393-404. doi: 10.1111/obr.12016.
Robberecht H, De Bruyne T, Hermans N. Biomarkers of the Metabolic Syndrome: Influence of Caloric Intake, Various Food Groups and Vitamins. Journal of Food and Nutrition Research. 2017;5(2):101-109. doi: 10.12691/jfnr-5-2-5.
Deleskog A, Hilding A, Brismar K, Hamsten A, Efendic S, Östenson CG. Low serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance. Diabetologia. 2012 Jun;55(6):1668-78. doi: 10.1007/s00125-012-2529-x.
Pinelli NR, Jaber LA, Brown MB, Herman WH. Serum 25-hydroxyvitamin D and insulin resistance, metabolic syndrome, and glucose intolerance among Arab Americans. Diabetes Care. 2010 Jun;33(6):1373-5. doi: 10.2337/dc09-2199.
Miller PD. Vitamin D, calcium, and cardiovascular mortality: a perspective from a plenary lecture given at the annual meeting of the American Association of Clinical Endocrinologists. Endocr Pract. 2011 Sep-Oct;17(5):798-806. doi: 10.4158/EP11203.RA.
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